scholarly journals A Clinicopathological Study of Mucocutaneous Lesions in Correlation with CD4 Counts in HIV Seropositive Cases at a Tertiary Care Centre in South India

2021 ◽  
Vol 01 (04) ◽  
Author(s):  
Metta Parvathi ◽  
Keyword(s):  
Andhra Pradesh ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Clinical Indicators ◽  
Cutaneous Manifestations ◽  
Cd4 Counts ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Hiv Seropositive

Background: Mucocutaneous lesions are one of the first clinical presentations of immunosuppression in Human Immunodeficiency Virus (HIV) seropositive patients that manifest at different stages of the infection that requires early diagnosis along with prompt treatment(1). Objectives: (1) To study the prevalence of mucocutaneous manifestations in HIV‑seropositive patients attending the ART center of our hospital in Visakhapatnam, Andhra Pradesh. (2) To correlate mucocutaneous manifestations with CD4 cell counts. Materials and methods: 150 HIV positive patients above 18 year old with definite cutaneous manifestations attending ART center and OPD in the Department of Dermatology and venereology in a tertiary care centre Visakhapatnam (Andhra Pradesh, India) were studied from May 2020 to May 2021. Results: Out of 150 HIV patients, who aged 20 -80 years with a mean age of 25, (23.8%) were 60 (40%) female and 90 (60%) were males, majority of the patients were labourers 50 (33.3%) by occupation , 41 (27.3%) had CD4 counts < 200, 73 (48.6%) had CD4 counts of 200–500, and 54 (36%) had CD4 counts > 500. The most common dermatological presentation was pruritic papular eruptions 24 (16.%) followed by cutaneous drug reaction 19(12.67%) and scabies 12 (8%). Conclusion: At the end of study we concluded that cutaneous manifestations can be considered as good clinical indicators for the progression of disease and underlying immune status in resource poor settings

CUTANEOUS MANIFESTATIONS OF HIV IN PEOPLE LIVING WITH HIV/AIDS AT TERTIARY CENTRE

2021 ◽  
pp. 70-72
Author(s):  
Anubhav Agrawal ◽  
Simmi Dube ◽  
Aditya Tejwani
Keyword(s):  
Cell Count ◽  
Tertiary Care ◽  
Skin Lesions ◽  
Cd4 Count ◽  
People Living With Hiv ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Cutaneous Manifestations ◽  
Cd4 Cell Count ◽  
Cd4 Cell

BACKGROUND-The study was conducted to describe systematic clinical manifestations among HIV in PLHA at tertiary care centre. METHODOLOGY- This study was designed as cross sectional study at Department of Medicine, tertiary care centre. A total of 100 HIV infected patients were included detailed enquiry about presence of skin lesions along with CD4 cell count was obtained and entered in pretested questionnaire RESULTS-The mean age of patients with HIV was 43.9±10.2 years and Slight female preponderance was observed with male: 3 female ratio of 0.89:1. Mean CD4 count was 243.2±103.2 cells/mm . Majority of patients had CD4 count in the range of less than 3 200 cells/mm (64%) Staphylococcal skin infections were the most common skin lesions observed in 34% patients. All the patients with cutaneous manifestations presented in present study had low CD4 cell count. However, no statistically signicant association between CD4 count and cutaneous manifestations could be documented (p>0.05). CONCLUSION-Cutaneous manifestations are more prevalent in patients with lower CD4 counts and can also be observed with normal CD4 count levels amongst patients with HIV. Occurrence of cutaneous manifestations was higher in patients with lower CD4 count but the observed difference was not statistically signicant.

CLINICAL PROFILE OF OUTPATIENTS ATTENDING DERMATOLOGY DEPARTMENT DURING COVID-19 LOCKDOWN RELAXATION PERIOD IN A TERTIARY CARE CENTRE IN SOUTH INDIA – A CROSS-SECTIONAL ANALYTICAL STUDY

2021 ◽  
pp. 13-16
Author(s):  
Afthab Jameela Wahab ◽  
Pavithra Gunasekaran ◽  
P. Mohan ◽  
V. Sudha ◽  
L. Balamurugan ◽  
...  
Keyword(s):  
South India ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Dermatology Department ◽  
Cutaneous Manifestations ◽  
Relaxation Period ◽  
Number Of Patients ◽  
Outpatient Practice ◽  
The Impact

Background - The cutaneous manifestations of the novel coronavirus have been well documented. However, there are few studies that relate to the clinical prole of regular dermatology outpatients seeking treatment during the lockdown relaxation period braving the pandemic. With the Aim - view to determine the changes seen in dermatology outpatient practice, this study analysed the clinical prole of new patients attending the Dermatology Outpatient Department (OPD) during the COVID-19 lockdown relaxation period in a tertiary care centre in a metropolitan suburb in South India. New dermatology outpatients during the months of May, June, July and August Method - 2020 were included in the study. Outpatient data for this period was analysed and compared with corresponding data for the same period in the previous two years. There was a Result – decrease in the OP census, number of patients in the extremes of life as well as those with asymptomatic dermatoses. There was an increase in the number of patients with infections, particularly dermatophytosis. There was also a noteworthy absence of dermatological emergencies. Conclusion - In essence, our study shows the impact of COVID-19 pandemic on the routine dermatology outpatient services with signicant changes in the clinical prole of outpatient practice following lockdown relaxation.

scholarly journals Treatment of CMV Retinitis with Intravitreal Ganciclovir in the HAART Era

2001 ◽  
Vol 12 (5) ◽  
pp. 300-304 ◽  
Author(s):  
Robert J Campbell ◽  
Benjamin Chow ◽  
Gary Victor ◽  
Steven Kravcik ◽  
William G Hodge
Keyword(s):  
Highly Active Antiretroviral Therapy ◽  
Tertiary Care ◽  
Tertiary Care Centre ◽  
Intravitreal Therapy ◽  
Cd4 Counts ◽  
Cmv Retinitis ◽  
Highly Active ◽  
Cell Counts ◽  
Secondary Objective ◽  
Complications And Mortality

OBJECTIVE:To describe the course and outcome of cytomegalovirus (CMV) retinitis among AIDS patients treated with intravitreal ganciclovir and systemic highly active antiretroviral therapy (HAART). The secondary objective was to compare the course of CMV retinitis between patients receiving HAART and those not receiving this treatment.DESIGN:A retrospective cohort design consisting of 21 eyes from 16 patients with AIDS and CMV retinitis consecutively enrolled between January 1996 and August 1999. All patients received intravitreal ganciclovir therapy, and half of the patients began HAART as well. Duration of intravitreal therapy and ensuing disease quiescence, as well as CD4+ T cell counts at diagnosis and at cessation of ganciclovir, were calculated. Secondly, instantaneous hazards for outcomes such as CMV retinitis progression, ocular complications and mortality were compared.SETTING:Tertiary care centre in Ottawa, Ontario.RESULTS:Five of eight patients receiving HAART discontinued intravitreal ganciclovir after a mean treatment period of 428 days. During this period, their mean CD4+ count rose from 7.5 to 190/mL. Subsequently, none of these patients experienced retinitis progression during follow-up periods lasting up to 820 days (mean of 617 days). Progression of CMV retinitis was 11.4 times more likely among those not receiving HAART (P=0.049).CONCLUSIONS:On initiating HAART, patients with CMV retinitis may enjoy significant recovery in CD4+ counts and sustained retinitis quiescence without specific anti-CMV therapy. Intravitreal ganciclovir injections seem well suited to offer effective CMV control during temporary periods of decreased CD4+ counts while awaiting HAART-mediated immune system reconstitution.

scholarly journals Virological Non-Suppression Among HIV-Positive Patients on Antiretroviral Therapy in Northwestern Nigeria: An Eleven-Year Experience of A Tertiary Care Centre, January 2009–December 2019

2021 ◽  
Author(s):  
Suleiman Bello Abdullahi ◽  
Olayinka Ibrahim ◽  
Abdulkadir Okeji ◽  
Yandoma Iliyasu ◽  
Ibrahim Bashir ◽  
...  
Keyword(s):  
Viral Suppression ◽  
Treatment Success ◽  
Tertiary Care ◽  
Hiv Positive ◽  
People Living With Hiv ◽  
Second Line ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Cd4 Counts ◽  
Human Immuno Deficiency Virus

Abstract Background: Human Immuno-Deficiency Virus (HIV) remains one of the world’s significant public health challenges. Viral suppression is the key indicator for treatment success in People living with HIV (PLHIV). We determined the level of viral non-suppression and its associated factors among PLHIV attending Federal Medical Centre Katsina (FMC Katsina), Nigeria. Methods: This retrospective descriptive study was conducted on 913 HIV positive adults enrolled in care between January 2009 and December 2019. Information on socio-demographics, clinical, immunological, Viral Load (VL) and other relevant parameters were extracted from the patients’ care Centre Katsina estimated frequencies/proportions, performed bivariate and multivariate analysis to determine factors associated with VL non-suppression using p<0.05 as significant level. Results: Records of 831 registered patients were analyzed using Epi-info 7. During the period, 751 (90.4%) achieved viral suppression, 426 (51.3%) had CD4 counts of ≥500 and 477 (57.4%) were on HAART for ≥5 years. Majority, 793 (95.4%) were on first-line and 809 (97.4%) in the non-advanced stage (WHO stages 1 and 2). The independent predictors of viral non-suppression included being on the second line HAART [Adjusted OR (AOR) 6.5; 95% CI 3.02-13.89], being employed [AOR 0.26; 95% CI 0.15-0.44] and baseline CD4 count less than 500 [AOR 0.35; 95% CI 0.21-0.61]. Conclusions: Our study demonstrated a good viral suppression among PLHIV on HAART. Low baseline CD4 counts and being on second-line HAART are predictive of viral non-suppression while being unemployed seems to be protective against viral non-suppression.

scholarly journals Cutaneous manifestations of chronic alcoholism: a cross sectional study in a tertiary care centre in South India

2016 ◽  
Vol 2 (4) ◽  
pp. 55
Author(s):  
Kumara Lakshmanan Sengotuven ◽  
Rangaraj Murugaiyan ◽  
Karthikeyan Kaliaperumal
Keyword(s):  
Tertiary Care ◽  
Chronic Alcoholism ◽  
Cross Sectional Study ◽  
Alcohol Dependency ◽  
Care Centre ◽  
Sectional Study ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Cutaneous Manifestations ◽  
Skin Manifestations

<p class="abstract"><strong>Background:</strong> Alcoholism is a chronic fatal disease of worldwide concern. Alcohol abuse can present in a variety of ways, and dermatological disease is emerging as an important marker of alcohol misuse. The aim is to find out the various skin manifestations associated in chronic alcoholics, to find out the most common skin manifestations among chronic alcoholics and to identify the early skin changes in chronic alcoholics.</p><p class="abstract"><strong>Methods:</strong> A cross sectional study conducted in patients attending medicine, psychiatry and dermatology clinics at a tertiary care centre, Puducherry. Inclusion criteria were patients with history of chronic alcoholism, aged above 18 years. After obtaining history, cutaneous examination was done including skin, mucosa, hairs, and nails. Alcohol dependency pattern was calculated using short alcohol dependency score (SADD).<strong></strong></p><p class="abstract"><strong>Results:</strong> A total of 130 patients were included. All were male and 59.2% of them belonged to high dependency pattern. About 128 of them had dermatological manifestations pityriasis versicolor was the most common dermatoses followed by psoriasis. Alcohol specific dermatoses were not seen in our study.</p><p><strong>Conclusions:</strong> In our study, 98.4% of alcoholics had skin manifestations, of which cutaneous infections were the most common. </p>

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