scholarly journals Virological Non-Suppression Among HIV-Positive Patients on Antiretroviral Therapy in Northwestern Nigeria: An Eleven-Year Experience of A Tertiary Care Centre, January 2009–December 2019

2021 ◽  
Author(s):  
Suleiman Bello Abdullahi ◽  
Olayinka Ibrahim ◽  
Abdulkadir Okeji ◽  
Yandoma Iliyasu ◽  
Ibrahim Bashir ◽  
...  
Keyword(s):  
Viral Suppression ◽  
Treatment Success ◽  
Tertiary Care ◽  
Hiv Positive ◽  
People Living With Hiv ◽  
Second Line ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Cd4 Counts ◽  
Human Immuno Deficiency Virus

Abstract Background: Human Immuno-Deficiency Virus (HIV) remains one of the world’s significant public health challenges. Viral suppression is the key indicator for treatment success in People living with HIV (PLHIV). We determined the level of viral non-suppression and its associated factors among PLHIV attending Federal Medical Centre Katsina (FMC Katsina), Nigeria. Methods: This retrospective descriptive study was conducted on 913 HIV positive adults enrolled in care between January 2009 and December 2019. Information on socio-demographics, clinical, immunological, Viral Load (VL) and other relevant parameters were extracted from the patients’ care Centre Katsina estimated frequencies/proportions, performed bivariate and multivariate analysis to determine factors associated with VL non-suppression using p<0.05 as significant level. Results: Records of 831 registered patients were analyzed using Epi-info 7. During the period, 751 (90.4%) achieved viral suppression, 426 (51.3%) had CD4 counts of ≥500 and 477 (57.4%) were on HAART for ≥5 years. Majority, 793 (95.4%) were on first-line and 809 (97.4%) in the non-advanced stage (WHO stages 1 and 2). The independent predictors of viral non-suppression included being on the second line HAART [Adjusted OR (AOR) 6.5; 95% CI 3.02-13.89], being employed [AOR 0.26; 95% CI 0.15-0.44] and baseline CD4 count less than 500 [AOR 0.35; 95% CI 0.21-0.61]. Conclusions: Our study demonstrated a good viral suppression among PLHIV on HAART. Low baseline CD4 counts and being on second-line HAART are predictive of viral non-suppression while being unemployed seems to be protective against viral non-suppression.

scholarly journals Viral suppression among HIV-positive patients on antiretroviral therapy in northwestern Nigeria: an eleven-year review of tertiary care centre records, January 2009–December 2019

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Suleiman Bello Abdullahi ◽  
Olayinka Rasheed Ibrahim ◽  
Abdulkadir Baba Okeji ◽  
Rabilu Iliyasu Yandoma ◽  
Ibrahim Bashir ◽  
...  
Keyword(s):  
Viral Load ◽  
Viral Suppression ◽  
Treatment Success ◽  
Tertiary Care ◽  
Cd4 Count ◽  
Hiv Positive ◽  
People Living With Hiv ◽  
First Line ◽  
Tertiary Care Centre ◽  
Cross Sectional

Abstract Background Human Immuno-Deficiency Virus (HIV) remains one of the world’s significant public health challenges. Viral suppression is the key indicator for treatment success in People living with HIV (PLHIV). We determined the level of viral suppression, and its associated factors among PLHIV attending Federal Medical Centre Katsina (FMC Katsina), Nigeria. Methods This retrospective descriptive cross-sectional study was conducted on 913 HIV positive adults enrolled in care between January 2009 and December 2019. Information on socio-demographics, clinical, immunological, Viral load (VL), and other relevant parameters were extracted from the patients’ care records. The primary outcome was the proportion of patients that achieved viral suppression. We also analyzed variables that were associated with VL suppression. Results Of 913, records of 831 (91.0%) registered patients were analyzed. During the period, 751 (90.4%) achieved viral suppression, 427 (51.4%) had CD4 counts  ≥ 500 and 477 (57.4%) were on HAART for ≥ 5 years. Majority, 793 (95.4%) were on first-line HAART regimen (Tenofovir-Lamivudine-Dolutegravir or Abacavir-Lamivudine-Dolutegravir), and 809 (97.4%) in the non-advanced stage (WHO stages 1 and 2). The median (interquartile range) of viral load was 20 (20–40) vs 19,989 (3311–110,340) cp/ml in virally suppressed, and unsuppressed  respectively. Factors associated with viral suppression included being unemployed (Adjusted OR [AOR] 4.9, 95% CI 2.771, 8.539), educated (AOR 4.2, 95% CI 1.098, 16.223), having a baseline CD4 count ≥ 500 cells/µl (AOR 2.7, 95% CI 1.588, 4.625), and being on first line HAART regimen [AOR 7.0, 95% CI 3.220, 15.648]. Conclusions Our study demonstrated a good viral suppression among PLHIV on HAART. Variables associated with viral suppression included unemployment, formal education, high baseline CD4 count, and first line HAART regimen.

CUTANEOUS MANIFESTATIONS OF HIV IN PEOPLE LIVING WITH HIV/AIDS AT TERTIARY CENTRE

2021 ◽  
pp. 70-72
Author(s):  
Anubhav Agrawal ◽  
Simmi Dube ◽  
Aditya Tejwani
Keyword(s):  
Cell Count ◽  
Tertiary Care ◽  
Skin Lesions ◽  
Cd4 Count ◽  
People Living With Hiv ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Cutaneous Manifestations ◽  
Cd4 Cell Count ◽  
Cd4 Cell

BACKGROUND-The study was conducted to describe systematic clinical manifestations among HIV in PLHA at tertiary care centre. METHODOLOGY- This study was designed as cross sectional study at Department of Medicine, tertiary care centre. A total of 100 HIV infected patients were included detailed enquiry about presence of skin lesions along with CD4 cell count was obtained and entered in pretested questionnaire RESULTS-The mean age of patients with HIV was 43.9±10.2 years and Slight female preponderance was observed with male: 3 female ratio of 0.89:1. Mean CD4 count was 243.2±103.2 cells/mm . Majority of patients had CD4 count in the range of less than 3 200 cells/mm (64%) Staphylococcal skin infections were the most common skin lesions observed in 34% patients. All the patients with cutaneous manifestations presented in present study had low CD4 cell count. However, no statistically signicant association between CD4 count and cutaneous manifestations could be documented (p>0.05). CONCLUSION-Cutaneous manifestations are more prevalent in patients with lower CD4 counts and can also be observed with normal CD4 count levels amongst patients with HIV. Occurrence of cutaneous manifestations was higher in patients with lower CD4 count but the observed difference was not statistically signicant.

Spectrum of neurological disorders in HIV positive patients attending a tertiary care centre of Eastern India

2021 ◽  
Vol 429 ◽  
pp. 118901
Author(s):  
Arpan Dutta ◽  
Alak Pandit ◽  
Biman Ray ◽  
Shantasil Pain ◽  
Goutam Gangopadhyay
Keyword(s):  
Neurological Disorders ◽  
Tertiary Care ◽  
Hiv Positive ◽  
Care Centre ◽  
Eastern India ◽  
Tertiary Care Centre

scholarly journals Seroprevalence of Hepatitis B and C Co-Infection in HIV Positive Patients in a Tertiary Care Centre

2019 ◽  
Vol 04 (09) ◽  
pp. 636-639
Author(s):  
P. Nagamani ◽  
S. Pavani ◽  
G. Jyothi Lakshmi ◽  
P. Shashikala Reddy
Keyword(s):  
Hepatitis B ◽  
Tertiary Care ◽  
Hiv Positive ◽  
Care Centre ◽  
Tertiary Care Centre

scholarly journals A Clinicopathological Study of Mucocutaneous Lesions in Correlation with CD4 Counts in HIV Seropositive Cases at a Tertiary Care Centre in South India

2021 ◽  
Vol 01 (04) ◽  
Author(s):  
Metta Parvathi ◽  
Keyword(s):  
Andhra Pradesh ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Clinical Indicators ◽  
Cutaneous Manifestations ◽  
Cd4 Counts ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Hiv Seropositive

Background: Mucocutaneous lesions are one of the first clinical presentations of immunosuppression in Human Immunodeficiency Virus (HIV) seropositive patients that manifest at different stages of the infection that requires early diagnosis along with prompt treatment(1). Objectives: (1) To study the prevalence of mucocutaneous manifestations in HIV‑seropositive patients attending the ART center of our hospital in Visakhapatnam, Andhra Pradesh. (2) To correlate mucocutaneous manifestations with CD4 cell counts. Materials and methods: 150 HIV positive patients above 18 year old with definite cutaneous manifestations attending ART center and OPD in the Department of Dermatology and venereology in a tertiary care centre Visakhapatnam (Andhra Pradesh, India) were studied from May 2020 to May 2021. Results: Out of 150 HIV patients, who aged 20 -80 years with a mean age of 25, (23.8%) were 60 (40%) female and 90 (60%) were males, majority of the patients were labourers 50 (33.3%) by occupation , 41 (27.3%) had CD4 counts < 200, 73 (48.6%) had CD4 counts of 200–500, and 54 (36%) had CD4 counts > 500. The most common dermatological presentation was pruritic papular eruptions 24 (16.%) followed by cutaneous drug reaction 19(12.67%) and scabies 12 (8%). Conclusion: At the end of study we concluded that cutaneous manifestations can be considered as good clinical indicators for the progression of disease and underlying immune status in resource poor settings

scholarly journals Seroprevalence of human immunodeficiency virus among reproductive age group females presenting with genital ulcer: study from a tertiary care centre in India

2020 ◽  
Vol 9 (9) ◽  
pp. 3737
Author(s):  
Tanreet Kaur ◽  
Harbhajan K. Shergill
Keyword(s):  
Human Immunodeficiency Virus ◽  
Condom Use ◽  
Tertiary Care ◽  
Hiv Positive ◽  
Age Group ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Genital Ulceration ◽  
Immunodeficiency Virus ◽  
Genital Ulcers

Background: The co-existence genital ulcers either in the recipient or donor could potentially increase the risk of transmission of human immunodeficiency virus (HIV). Hence the meticulous clinical and serologic evaluation of females presenting with genital ulceration is important to curb the future spread of HIV.Methods: A total 80 female patients within the age group 15-45 years presenting with genital ulceration were enrolled in the study done at tertiary care centre in Amritsar for a period of one year. Various investigations such as Tzanck smear, VDRL, gram staining, genital mucosal biopsy, HSV serology and HIV testing - ELISA and Tri dot were done on study participants.Results: Out of 80 females, 8 patients with genital ulceration tested positive for HIV. Most common cause of genital ulceration in HIV positive female patients was herpes progenitalis (50%). Only 25% of HIV seropositive females were married rest were widowed or unmarried. History of condom use was absent in 62.5% of HIV positive females.Conclusions: Pre-existing genital ulcers due to sexually transmitted diseases (STD) or due to non-STDs, inconsistent condom use, urbanization and pre/extra marital affairs are risk factors for the acquisition of HIV.

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