Giant parathyroid adenoma diagnosed by brown tumor, a clinical manifestation of primary hyperparathyroidism: a case report

Abstract Brown tumor (BT) is the pathological expression of osteitis fibrosa cystica owing to primary and secondary hyperparathyroidism (HPT). It is a rare benign lesion of skeletal system that usually affects the facial bones, clavicles, ribs, pelvis and extremities. The purpose of this case report is to present the clinical, pathological and radiological findings of BT, rarely seen in adults, originating from the giant parathyroid adenoma and emerging as the first clinical sign of HPT. The patient underwent a successful parathyroidectomy operation and on the first postoperative day, the patient was discharged without any complications. Continuous...

Download Full-text

A Reference Finding Rarely Seen in Primary Hyperparathyroidism: Brown Tumor

Case Reports in Medicine ◽

10.1155/2012/432676 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 6

Author(s):

F. Mantar ◽

S. Gunduz ◽

U. R. Gunduz

Keyword(s):

Bone Loss ◽

Primary Hyperparathyroidism ◽

Parathyroid Adenoma ◽

Male Patient ◽

Surgical Procedures ◽

Bone Disease ◽

Bone Lesion ◽

Brown Tumor ◽

Osteitis Fibrosa Cystica ◽

Localized Form

Primary hyperparathyroidism is an endocrinopathy which is characterized with the hypersecretion of parathormone. During the progress of the disease bone loss takes place due to resorption on the subperiosteal and endosteal surfaces. Brown tumor is a localized form of osteitis fibrosa cystica, being part of the hyperparathyroid bone disease. It is rarely the first symptom of hyperparathyroidism. Nowadays, the diagnosis is made at an asymptomatic or minimally symptomatic stage. We present a male patient presented with a massive painless swelling in the left maxilla as the first manifestation of primary hyperparathyroidism due to a parathyroid adenoma. Parathyroidectomy was performed, and there was a regression of the bone lesion, without the need of performing other local surgical procedures.

Download Full-text

Hyperparathyroidism due to Parathyroid Adenoma with Co-existing Vitamin D Deficiency A Case Report

BIRDEM Medical Journal ◽

10.3329/birdem.v5i2.28389 ◽

2016 ◽

Vol 5 (2) ◽

pp. 104-106

Author(s):

Md Raziur Rahman ◽

Mohammad Abdul Hannan ◽

Samira Rahat Afroze ◽

Sultana Marufa Shefin ◽

Muhammad Abdur Rahim ◽

...

Keyword(s):

Vitamin D ◽

Case Report ◽

Primary Hyperparathyroidism ◽

Secondary Hyperparathyroidism ◽

Parathyroid Adenoma ◽

Vitamin D Deficiency ◽

Musculoskeletal Symptoms ◽

Asymptomatic Hyperparathyroidism ◽

Routine Investigations

Primary hyperparathyroidism is often asymptomatic, may be detected during routine investigations or may present with features of hypercalcaemia. Vitamin D deficiency causing secondary hyperparathyroidism presents with musculoskeletal symptoms. Studies have shown an association between primary hyperparathyroidism and vitamin D deficiency. It has also been observed that when co-exist, these two conditions contribute to each others disease presentation and severity. This case report depicts initial asymptomatic hyperparathyroidism developing symptoms due to co-existing parathyroid adenoma and vitamin D deficiency in a 26-year-old muslim Bangladeshi female who responded well to adequate pre, per and post parathyroidectomy medical managementBirdem Med J 2015; 5(2): 104-106

Download Full-text

Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report

Hemodialysis International ◽

10.1111/hdi.12298 ◽

2015 ◽

Vol 19 (4) ◽

pp. 583-592 ◽

Cited By ~ 7

Author(s):

Rafael M. Baracaldo ◽

Dashi Bao ◽

Pichet Iampornpipopchai ◽

Joshua Fogel ◽

Sofia Rubinstein

Keyword(s):

Systematic Review ◽

Case Report ◽

Secondary Hyperparathyroidism ◽

Osteitis Fibrosa ◽

Illustrative Case ◽

Brown Tumor ◽

Osteitis Fibrosa Cystica ◽

Facial Disfigurement

Download Full-text

A RARE CASE OF MAXILLARY BROWN TUMOUR AS PRIMARY PRESENTATION OF THE PARATHYROID CARCINOMA.

10.36106/ijsr/4101970 ◽

2021 ◽

pp. 63-65

Author(s):

Fehmida M Laxmidhar ◽

Bhavin P. Vadodariya ◽

Sanjiv Shah ◽

Murtuza I Laxmidhar

Keyword(s):

Case Report ◽

Soft Tissue ◽

Primary Hyperparathyroidism ◽

Parathyroid Carcinoma ◽

Frozen Section ◽

Elevated Serum ◽

Brown Tumor ◽

Facial Bones ◽

Elderly Male ◽

Brown Tumors

Background: Brown tumours are expansile osteolytic lesions of bone, occurring in Hyperparathyroidism. Brown tumours occur most commonly in ribs, clavicle, long bones and pelvis and are uncommon in other facial bones except mandible. Other facial bones are rarely affected. Brown tumors are due to the direct effect of the parathyroid hormone. Brown tumors occur more with primary hyperparathyroidism than secondary. However, they are reported more in secondary hyperparathyroidism. In primary hyperparathyroidism, a parathyroid adenoma is a cause in 81% while other causes include hyperplasia in 15% and parathyroid carcinoma only in 4%. We present a case report of maxillary Brown tumor due to parathyroid carcinoma in an elderly male patient. Case Report: A 67-year-old male presented with right maxillary swelling increasing in size for the last few months associated with ipsilateral nasal block and right eye epiphora. The contrast CT scan of paranasal sinuses and neck revealed a large expansile right maxillary tumor aggressively eroding maxillary wall with extension into the orbital oor, ethmoid, sphenoid sinuses, nasal cavity, and oral cavity with the erosion of hard palate and soft tissue extension to subcutaneous Plane. A three cm sized soft tissue density lesion was also noted posterior to the right thyroid lobe in CT sections of the neck. Blood prole was normal except extremely high serum parathormone and calcium as well as mildly elevated serum creatinine (S. PTH 3437 pg./ml. S. Ca. 19 mg%. S. Creatinine 1.77mg%.) Ultrasonography of the abdomen also revealed calcication in the renal medulla. Right lower parathyroidectomy was done with the frozen section as well as the Intraoperative Rapid PTH assay. The PTH level was reduced by 90 percent of the original value. The nal histopathology was suggestive of parathyroid carcinoma. Summary: The patient was under regular surveillance, as the maxillary tumor was under remittance after the resection of parathyroid carcinoma. Parathyroid carcinoma is a very rare tumor and involvement of maxillary bone due to primary hyperparathyroidism due to parathyroid carcinoma is also uncommon.

Download Full-text