scholarly journals Hyperparathyroidism due to Parathyroid Adenoma with Co-existing Vitamin D Deficiency – A Case Report

2016 ◽  
Vol 5 (2) ◽  
pp. 104-106
Author(s):  
Md Raziur Rahman ◽  
Mohammad Abdul Hannan ◽  
Samira Rahat Afroze ◽  
Sultana Marufa Shefin ◽  
Muhammad Abdur Rahim ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Report ◽  
Primary Hyperparathyroidism ◽  
Secondary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Vitamin D Deficiency ◽  
Musculoskeletal Symptoms ◽  
Asymptomatic Hyperparathyroidism ◽  
Routine Investigations

Primary hyperparathyroidism is often asymptomatic, may be detected during routine investigations or may present with features of hypercalcaemia. Vitamin D deficiency causing secondary hyperparathyroidism presents with musculoskeletal symptoms. Studies have shown an association between primary hyperparathyroidism and vitamin D deficiency. It has also been observed that when co-exist, these two conditions contribute to each other’s disease presentation and severity. This case report depicts initial asymptomatic hyperparathyroidism developing symptoms due to co-existing parathyroid adenoma and vitamin D deficiency in a 26-year-old muslim Bangladeshi female who responded well to adequate pre, per and post parathyroidectomy medical managementBirdem Med J 2015; 5(2): 104-106

Giant parathyroid adenoma diagnosed by brown tumor, a clinical manifestation of primary hyperparathyroidism: a case report

2021 ◽  
pp. 1-8
Author(s):  
Banu Yigit ◽  
Mert Tanal ◽  
Bulent Citgez
Keyword(s):  
Case Report ◽  
Primary Hyperparathyroidism ◽  
Secondary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Benign Lesion ◽  
Brown Tumor ◽  
Skeletal System ◽  
Radiological Findings ◽  
Facial Bones ◽  
Osteitis Fibrosa Cystica

Abstract Brown tumor (BT) is the pathological expression of osteitis fibrosa cystica owing to primary and secondary hyperparathyroidism (HPT). It is a rare benign lesion of skeletal system that usually affects the facial bones, clavicles, ribs, pelvis and extremities. The purpose of this case report is to present the clinical, pathological and radiological findings of BT, rarely seen in adults, originating from the giant parathyroid adenoma and emerging as the first clinical sign of HPT. The patient underwent a successful parathyroidectomy operation and on the first postoperative day, the patient was discharged without any complications. Continuous...

Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism

1987 ◽  
Vol 73 (6) ◽  
pp. 659-664 ◽  
Author(s):  
M. R. Clements ◽  
M. Davies ◽  
D. R. Fraser ◽  
G. A. Lumb ◽  
E. Barbara Mawer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Vitamin D Deficiency ◽  
Metabolic Clearance ◽  
Half Time ◽  
Hydroxyvitamin D ◽  
Elimination Half ◽  
Before And After ◽  
25 Hydroxyvitamin D

1. The elimination half-time of 25-hydroxyvitamin D in plasma was estimated after intravenous injection of the radioactively labelled metabolite in seven patients with primary hyperparathyroidism before and after excision of a parathyroid adenoma. 2. The elimination half-time of 25-hydroxyvitamin D was significantly shortened in primary hyperparathyroidism and reverted towards normal after parathyroidectomy. 3. The increased metabolic clearance of 25-hydroxyvitamin D in primary hyperparathyroidism was accounted for by an increased excretion of vitamin D-derived inactivation products in the faeces. 4. Enhanced hepatic inactivation of 25-hydroxyvitamin D may be important in the development of vitamin D deficiency in primary hyperparathyroidism.

scholarly journals Intrathymic ectopic parathyroid adenoma caused primary hyperparathyroidism with vitamin D deficiency several years after bariatric surgery

2015 ◽  
Vol 6 (1) ◽  
pp. 101-104 ◽  
Author(s):  
Francesco Sellitri ◽  
Alessandro Tamburrini ◽  
Federico Tacconi ◽  
Patrizio Bollero ◽  
Andrea Ortensi ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Vitamin D Deficiency ◽  
Ectopic Parathyroid Adenoma ◽  
Ectopic Parathyroid

scholarly journals Primary Hyperparathyroidism From Ectopic Parathyroid Adenoma in a Patient With Bilateral Slipped Capital Femoral Epiphysis

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A213-A214
Author(s):  
Rebecca J Vitale ◽  
Hester Shieh ◽  
Biren P Modi ◽  
Rebecca J Gordon
Keyword(s):  
Vitamin D ◽  
Case Report ◽  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Pediatric Patients ◽  
Weight Bearing ◽  
Slipped Capital Femoral Epiphysis ◽  
Autism Spectrum ◽  
Ectopic Parathyroid Adenoma ◽  
Ectopic Parathyroid

Abstract Background: Primary hyperparathyroidism has been reported in 13 pediatric patients presenting with slipped capital femoral epiphysis (SCFE), but never in patients with ectopic parathyroid adenoma [1]. Case report: A 12-year-old boy with obesity (BMI 99th percentile) and autism spectrum disorder presented with a limp and was found to have bilateral SCFE. Calcium was elevated to 12.3 mg/dL (reference range 8.0–10.5) with phosphorus of 3.2 mg/dL (3.0–5.7), alkaline phosphatase 775 units/L (40–360), tubular reabsorption of phosphorus 89% (&gt 95%), 25OH-vitamin D 12.1 ng/mL (30–80), 1,25OH-vitamin D 246.6 pg/mL (19.9–79.3), and PTH 1191 pg/mL (10–65). He had significant neuropsychiatric agitation but denied constipation, polyuria, and other symptoms of hypercalcemia. He had in situ pinning of the SCFE bilaterally and was hyperhydrated with minimal improvement in his calcium level. Neck ultrasound revealed no parathyroid adenoma. He was discharged on cholecalciferol 1000 IU daily with plans for outpatient Tc-99m Sestamibi scintigraphy. Following discharge, he developed significant nausea, did not tolerate the cholecalciferol, and was non-weight bearing. Repeat labs and imaging 5 days later demonstrated calcium had risen to 16.7 mg/dL with phosphorus of 2.2 mg/dL. He was admitted and calcium improved transiently to less than 12 mg/dL with intranasal calcitonin therapy. Sestamibi and subsequent CT scan revealed a 2.7x1.6x1.9 cm ectopic parathyroid adenoma in the upper anterior mediastinum. He had thoracoscopic resection of the mass, which was revealed to be intrathymic, and PTH levels fell from 1613 pg/mL pre-operatively to 76 pg/mL 30 minutes post-resection. Post-operatively, he developed hungry bone syndrome with a calcium nadir of 7.6 mg/dL and phosphorus nadir of 1.6 mg/dL, which required oral calcium and calcitriol for 10 days. With normalization of his calcium, his neuropsychiatric symptoms improved. Pathology revealed a parathyroid adenoma. Conclusion: Primary hyperparathyroidism can be associated with SCFE and should be considered even in patients with traditional risk factors for SCFE, especially with bilateral disease. Pediatric patients with primary hyperparathyroidism and negative neck imaging should be further evaluated for ectopic parathyroid adenomas. References: 1. George, G.S., Raizada, N., Jabbar, P.K., Chellamma, J., Nair, A. Slipped Capital Femoral Epiphysis in Primary Hyperparathyroidism - Case Report with Literature Review. Indian J Endocrinol Metab. 2019 Jul-Aug;23(4):491–494.

Metacarpal Brown Tumor in Secondary Hyperparathyroidism Due to Vitamin-D Deficiency: A Case Report

2005 ◽  
Vol os-87 (6) ◽  
pp. 1363-1366 ◽  
Author(s):  
E. Erturk ◽  
M. Keskin ◽  
C. Ersoy ◽  
T. Kaleli ◽  
S. Imamoglu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Report ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Brown Tumor

scholarly journals MON-346 Secondary Hyperparathyroidism and Other Complications in a Post-Roux-En-Y Patient: A Case Report

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Jessica Michelle Chan ◽  
Bradley S Havins
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Gastric Bypass ◽  
Case Report ◽  
Vitamin B12 ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
The United States ◽  
American Society ◽  
Metabolic And Bariatric Surgery

Abstract Roux-en-y Gastric Bypass is a very common surgical procedure in managing morbid obesity. Approximately 303,890 roux-en-y surgeries were performed in the United States in between the years of 2012 to 2017, and the number is steadily increasing as more Americans are diagnosed with obesity.i This featured case report describes a 52-year-old female presenting with complications seven years following Roux-en-y gastric bypass. Four years post-operatively, she presented to the ER with a pelvis fracture. It was incidentally found that she had osteoporosis with a t-score of -2.9. It was also found that her bone mineral density (BMD) for women for her age was low with a z-score of -3.5 and her 10-year probability of getting fractures was high with a Fracture Risk Assessment Tool (FRAX) score of 6.2%. Seven years following Roux-en-y gastric bypass, she presented to our primary care office with Vitamin B12 deficiency and secondary hyperparathyroidism due to Vitamin D deficiency. We attempted to correct the deficiencies with high dose of Vitamin D, Vitamin B12, and calcium citrate. Eight months later, the B12 levels was normalized, but the secondary hyperparathyroidism and Vitamin D deficiency were not corrected. This case illustrates the complications that can occur following a Roux-en-y Gastric Bypass, importance of supplement compliance, and proper follow-up with Roux-en-y patients. Endnotes i American Society for Metabolic and Bariatric Surgery. (2018). Estimate of Bariatric Surgery Numbers, 2011-2017 | American Society for Metabolic and Bariatric Surgery. [online] Available at: https://asmbs.org/resources/estimate-of-bariatric-surgery-numbers [Accessed 31 Oct. 2019].

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