scholarly journals Trombositopenia Berat pada Ibu Hamil dengan Sistemik Lupus Erythematosus yang Dilakukan Seksio Sesarea

2020 ◽  
Vol 3 (2) ◽  
pp. 102-110
Author(s):  
Mariza Fitriati ◽  
Ratih Kumala Fajar Apsari ◽  
Sri Rahardjo

Trombositopenia adalah hal yang umum muncul pada kehamilan normal, disebut trombositopenia berat bila jumlah trombosit <50.000 /µL. Komplikasi kehamilan oleh penyakit Lupus Eritematosus Sistemik (Systemic Lupus Erythematosus = SLE) dapat menimbulkan trombositopenia berat patologis. Karena peran penting trombosit dalam pembekuan darah, dilain pihak proses persalinan akan menimbulkan perdarahan, maka dibutuhkan jumlah dan fungsi trombosit yang cukup. Trombositopenia-SLE berderajat berat perlu mendapat terapi untuk meningkatkan jumlah dan fungsi trombosit sebelum menjalani persalinan. Upaya peningkatan jumlah trombosit pada trombositopenia-SLE diawali dengan kortikosteroid sebagai terapi awal, dengan terapi alternatif lanjutan imunosupresif, splenektomi, plasmaferesis, trombopoetic, dan konsentrat trombosit. Pada kasus ini trombositopenia tidak dapat teratasi, sehingga pemeriksaan fungsional pembekuan darah bleeding time dan clotting time digunakan untuk membantu memperkirakan kemungkinan terjadi perdarahan berkelanjutan. Perhatian utama pada pemilihan tehnik anestesi kasus ini adalah kemungkinan terjadi perdarahan berkelanjutan, dalam hal ini dipilih yang dipertimbangkan berisiko terkecil yaitu total intravenous anesthesia (TIVA) dengan ketamin. Perawatan pasca operasi dilaksanakan juga dengan tetap mewaspadai kemungkinan terjadi perdarahan berkelanjutan.   Severe Trombositopenia in Pregnant Woman with Sistemic Lupus Erythematosus Ongoing Caesarean Section Abstract Thrombocytopenia is a common occurrence in normal pregnancy, will classified as severe thrombocytopenia if platelet count <50.000/ µL. Pregnancy complicated by Systemic Lupus Erythematosus (SLE) can lead to pathological severe thrombocytopenia. As thrombocytes has a main role in haemostasis, and delivery process will always caused bleeding, thrombocytes needed in proper amount and function. Severe SLE-Thrombocytopenia has to treat aiming higher total thrombocytes and function before delivery. Effort in raising thrombocytes count on SLE-thrombocytopenia patients recommended starting from corticosteroid as first line treatment, followed by any alternatif therapy if thrombocytes count did not responds to corticosteroid therapy, such as immunosuppresif drugs, splenectomy, plasmapharesis, thrombopoetic drugs, and trombocyte concentrate. In this case, severe thrombocytopenia couldn’t be resolved, so then the bleeding time and clotting time taken as tools to estimate blood’s ability to coagulate. The main consideration on choosing anesthesia’s plan in this case is possibility condition to held uncontrolled bleeding. Therefore, the procedure with the lowest risk for maternal and fetal, total intravenous anesthesia with ketamin, had chosen. Caring for post operative SLE-thrombocytopenia patient should never ignoring vigilance for sustainable bleeding.

2012 ◽  
Vol 71 (Suppl 1) ◽  
pp. A34.1-A34
Author(s):  
Ahsen Morva ◽  
Sébastien Lemoine ◽  
Achouak Achour ◽  
Alain Saraux ◽  
Jacques-Olivier Pers ◽  
...  

1994 ◽  
Vol 73 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Satomi Ohsako ◽  
Masako Hara ◽  
Masayoshi Harigai ◽  
Chikako Fukasawa ◽  
Sadao Kashiwazaki

2019 ◽  
Vol 20 (9) ◽  
pp. 2154 ◽  
Author(s):  
Mercurio ◽  
Lobasso ◽  
Barbieri ◽  
Parrella ◽  
Ciervo ◽  
...  

Background and aim: Systemic lupus erythematosus (SLE) is associated with increased risk of cardiovascular disease (CVD). Among many mechanisms, accelerated atherosclerosis, endothelial dysfunction, and hypercoagulability play a main role. Here, we investigate whether inflammatory, serological and clinical markers of SLE determine and correlate with arterial stiffness in SLE patients. Materials and methods: Routine blood samples, inflammatory mediators, specific antibodies, and 24 h proteinuria were measured in 43 SLE patients and 43 age and sex-matched controls using routine laboratory assays. We also assessed arterial stiffness by measuring radial artery applanation tonometry-derived augmentation index (AI), normalized AI (AIx@75), aortic pulse pressure, central systolic, diastolic and peripheral blood pressure. Results: SLE patients showed a significantly greater arterial stiffness vs. controls, as demonstrated by the significantly higher AIx@75 and aortic pulse pressure. Interestingly, regression analysis showed that age, systolic pulse pressure, inflammatory markers (erythrocyte sedimentation rate and C-reactive protein), daily dose of glucocorticoids, and cumulative organ damage positively correlated with arterial stiffness. Conclusions: SLE patients show increased arterial stiffness which correlates with markers of inflammation, that is involved in early alterations in arterial walls. Applanation tonometry can be used to screen SLE patients for subclinical vascular damage to implement prevention strategies for CVD.


2005 ◽  
Vol 20 (6) ◽  
pp. 540-543 ◽  
Author(s):  
G. Daskalakis ◽  
N. Papantoniou ◽  
S. Marinopoulos ◽  
E. Vomvolaki ◽  
I. Papageorgiou ◽  
...  

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