The advantages of albumin over less costly alternative fluids continue to be debated. Many scientific articles were devoted to the clinical analysis of the use of albumin in acute illness as well as its comparison with other fluid regimens. However, the lack of fundamental knowledge about the physical and chemical properties of commercial albumin generates many unpromising discussions about the effectiveness of the use of albumin among practitioners and medical scientists. The manuscript provides information about the different variants of commercial albumin, the mechanisms of their action, indications and contraindications to use. The main purpose of this article is to objectively show the failure of generalizing conclusions and recommendations on the clinical use of commercial albumin, taking into account its various physical and chemical characteristics. To date, all studies should be conducted either in the form of a comparative analysis of a specific clinical effect, or within the framework of studies of only one brand of albumin. Otherwise, generalizing the conclusions, the recommendations on the use of different forms of albumin are not correct and generate a lot of useless of the discussions. The presented information is based on fundamental knowledge of physical and chemical properties of commercial albumin. This manuscript is not only educational information, but also is scientific guide for clinicians.
Guidelines for Therapeutic Drug Monitoring of Cardiovascular Drugs Clinical Use of Blood Drug Concentration Monitoring (JCS 2015) ― Digest Version ―
