Effect of a synbiotic, ColonFit, in patients with irritable bowel syndrome, functional constipation and functional diarrhea

2020 ◽  
Vol 74 (6) ◽  
pp. 535-542
Author(s):  
Radek Kroupa ◽  
Jiří Jarkovský ◽  
Barbora Packová ◽  
Šárka Doležalová ◽  
Hana Junková ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Functional Constipation ◽  
Bowel Symptoms ◽  
Functional Diarrhea ◽  
Initial Symptoms ◽  
Bowel Diseases ◽  
Bowel Movements ◽  
Bristol Stool Scale ◽  
Irritable Bowel

Background: Supplementary dietary fiber and probiotics may improve bowel symptoms due to changes in microbiome and fermentation. The aim of the study was the evaluation of symbiotic with psyllium, ColonFit, in patients with functional colonic diseases. Patients and Methods: A prospective observational study in patients with irritable bowel syndrome, functional constipation and functional diarrhea for a 4-week intake of ColonFit 10 g daily. The type and severity of bowel symptoms (scale 1–5), number and consistency of stool and quality of life features were analyzed in subgroups according to dominant initial symptoms. Results: Complete data were available from 110 patients (mean age 49.9 ± 15.3 years, 58.2% females). Constipation related symptoms were predominant in 46 (41.8%) patients, diarrhea in 28 (25.5%) and mixed type in the rest. The symptoms in constipation predominant group were more severe than in others. The significant change in softening of stool consistency (from 1.9 to 3.8 in Bristol stool scale; p < 0.001), an increase in spontaneous bowel movements (from 3.1 to 5.6× weekly; p = 0,001) and reduction of incomplete bowel movements of 40% and abdominal pain of 42% were observed in constipated patients. The reduction in a number of bowel movement per week (from 17.8 to 13.6; p = 0.001) and improvement of abdominal cramps by 27% and reduction of dietary limitations by 30% were recorded in diarrhea subgroup. The beneficial effect lasted for a two-week follow up after the discontinuation of ColonFit use. Conclusion: The ColonFit use was most beneficial in constipated patients. The improvement of several symptoms was observed in other subtypes of irritable bowel syndrome without any worsening of troubles. The use of the combination of psyllium, inulin and probiotics may offer an effective alternative for the management of functional bowel diseases.

Irritable bowel syndrome – a common problem, individual approach

2021 ◽  
Vol 14 (4) ◽  
pp. 369-374
Author(s):  
Barbara Skrzydło-Radomańska ◽  
Bartosz J. Sapilak
Keyword(s):  
Irritable Bowel Syndrome ◽  
Clinical Symptoms ◽  
Recurrent Abdominal Pain ◽  
Frequency Change ◽  
High Fiber ◽  
Fiber Diet ◽  
Bowel Movements ◽  
Irritable Bowel ◽  
Effective Drugs

Irritable bowel syndrome is a recurrent abdominal pain that occurs at least once a week for 3 months, with symptoms at least 6 months associated with at least two features: bowel movements, change in bowel frequency, change in the appearance of stools. According to the Rome IV Diagnostic Criteria, the disease is diagnosed on the basis of clinical symptoms. This does not apply to people over 50 years of age (and in the case of first-degree relatives of patients with colorectal cancer after 45 years of age) and patients with alarm symptoms. Due to the lack of a single etiological factor, the treatment of irritable bowel syndrome consists in reducing symptoms and improving the patient’s quality of life. Non-pharmacological treatment includes a high-fiber diet and modification of the microbiota. The most effective drugs are antispasmodics directly affecting the smooth muscle, inhibiting the influx of calcium, i.e. drotaverine, mebeverine and alverine. There has been proven effectiveness of antidepressants. This confirms that functional disorders of the gastrointestinal tract are a manifestation of the dysfunction of the brain–gut–microbiota axis.

scholarly journals Disaharidase deficiency – is one of the causes of functional disorders of intestine.

2018 ◽  
Vol 96 (4) ◽  
pp. 365-370
Author(s):  
Asfold I. Parfenov ◽  
O. V. Ahmadullina ◽  
N. I. Belostoskij ◽  
E. A. Sabelnikova ◽  
S. V. Bykova ◽  
...  
Keyword(s):  
Bowel Disease ◽  
Functional Constipation ◽  
Normal Activity ◽  
Functional Bowel Disease ◽  
Functional Diarrhea ◽  
Intestinal Infections ◽  
Bowel Diseases ◽  
Activity Of Enzymes ◽  
Irritable Bowel ◽  
Duodenal Biopsies

The aim of the study was to show the importance of intestinal carbohydrase (glucoamylase, maltase, sucrase and lactase) in the etiology and pathogenesis of functional bowel diseases. Material and methods. It was examined 74 patients with FBD in age from 18 to 50 years (36 men and 38 women.). According to Rome IV criteria (2016) 21 had irritable bowel syndrome (IBS) with predominance of diarrhea , 33 functional diarrhea, 6 - IBS with predominant constipation , 4 functional constipation and 10 IBS mixed type. Karbohidrase activity in mucosa of the small intestine was investigated by the method of Dahlquist modification Trinder in duodenal biopsies obtained during esophagogastroduodenoscopy. Results. Lactase deficiency identified in 87.8%, maltasa - 48.6 percent, saharasia - 51,3%, the lack of glucoamylase - in 85.1% of patients. The activity of all investigated enzymes was reduced in 23 (31.1%) patients with functional bowel disease. Normal activity of enzymes have 4 (5,4%) patients. Conclusion. In 70 of 74 patients with functional bowel disease violations of the chair, abdominal pain and flatulence due to the decrease in the activity of carbohydrase of mucosa. The reason of disaccharidase deficiency may be due to the acute intestinal infections, antibiotic and medicine (NSAIDs) treatment.

scholarly journals Disaccharidase deficiency and functional bowel diseases

2017 ◽  
Vol 89 (4) ◽  
pp. 45-52 ◽  
Author(s):  
A I Parfenov ◽  
O V Akhmadullina ◽  
E A Sabelnikova ◽  
N I Belostotsky ◽  
M V Kirova ◽  
...  
Keyword(s):  
Functional Constipation ◽  
Biopsy Specimens ◽  
Functional Diarrhea ◽  
Intestinal Infections ◽  
Bowel Diseases ◽  
Precise Diagnosis ◽  
Intestine Mucosa ◽  
Inflammatory Drugs ◽  
Irritable Bowel

Aim. To elucidate the role of intestinal carbohydrases (glucoamylase, maltase, sucrose, and lactase) in the etiology and pathogenesis of functional bowel diseases (FBD). Subjects and methods. 74 patients (36 men and 38 women) aged 18 to 50 years with FBD were examined. According to Rome IV criteria (2016), there was diarrhea-predominant irritable bowel syndrome (IBS) in 21 patients, functional diarrhea (FD) in 33, constipation-predominant IBS in 6, functional constipation (FC) in 4, and mixed IBS in 10. The activity of carbohydrases in the small intestine mucosa (SIM) was investigated by the Dahlquist method modified by Trinder in the duodenal biopsy specimens obtained during esophagogastroduodenoscopy. Results. Lactase deficiency was identified in 87.8% of the patients; maltase deficiency in 48.6%; sucrose deficiency in 51.3%; and glucoamylase deficiency in 85.1%. The activity of all the investigated enzymes was reduced in 23 (31.1%) patients with FBD; deficiency of 1—3 carbohydrases was found in 47 (63.5%). Normal enzymatic activity was established in 4 (5.4%) patients. Conclusion. In the majority of patients with FBD, the intestinal symptoms are caused by the decreased activity of SIM carbohydrases. Therefore, disaccharidase deficiency associated with an established damaging agent (nonsteroidal anti-inflammatory drugs, antibiotics, acute intestinal infections, etc.) should be considered to be a more precise diagnosis.

scholarly journals Acupuncture for Adults with Diarrhea-Predominant Irritable Bowel Syndrome or Functional Diarrhea: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-16
Author(s):  
Jianbo Guo ◽  
Xiaoxiao Xing ◽  
Jiani Wu ◽  
Hui Zhang ◽  
Yongen Yun ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Clinical Effectiveness ◽  
Risk Of Bias ◽  
Acupuncture Group ◽  
Total Efficiency ◽  
Functional Diarrhea ◽  
Trimebutine Maleate ◽  
Irritable Bowel

Objective. To evaluate the clinical effectiveness and safety of acupuncture therapy in the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) or functional diarrhea (FD) in adults. Method. Five electronic databases—PubMed, EMBASE, CNKI, VIP, and Wanfang—were searched, respectively, until June 8, 2020. The literature of clinical randomized controlled trials of acupuncture for the treatment of IBS-D or FD in adults were collected. Meta-analysis was conducted by Using Stata 16.0 software, the quality of the included studies was assessed by the RevMan ROB summary and graph, and the results were graded by GRADE. Result. Thirty-one studies with 3234 patients were included. Most of the studies were evaluated as low risk of bias related to selection bias, attrition bias, and reporting bias. Nevertheless, seven studies showed the high risk of bias due to incomplete outcome data. GRADE’s assessments were either moderate certainty or low certainty. Compared with loperamide, acupuncture showed more effectiveness in weekly defecation ( SMD = − 0.29 , 95% CI [-0.49, -0.08]), but no significant improvement in the result of the Bristol stool form ( SMD = − 0.28 , 95% CI [-0.68, 0.12]). In terms of the drop-off rate, although the acupuncture group was higher than the bacillus licheniformis plus beanxit group ( RR = 2.57 , 95% CI [0.24, 27.65]), loperamide group ( RR = 1.11 , 95% CI [0.57, 2.15]), and trimebutine maleate group ( RR = 1.19 , 95% CI [0.31, 4.53]), respectively, it was lower than the dicetel group ( RR = 0.83 , 95% CI [0.56, 1.23]) and affected the overall trend ( RR = 0.93 , 95% CI [0.67, 1.29]). Besides, acupuncture produced more significant effect than dicetel related to the total symptom score ( SMD = − 1.17 , 95% CI [-1.42, -0.93]), IBS quality of life ( SMD = 2.37 , 95% CI [1.94, 2.80]), recurrence rate ( RR = 0.43 , 95% CI [0.28, 0.66]), and IBS Symptom Severity Scale ( SMD = − 0.75 , 95% CI [-1.04, -0.47]). Compared to dicetel ( RR = 1.25 , 95% CI [1.18, 1.32]) and trimebutine maleate ( RR = 1.35 , 95% CI [1.13, 1.61]), acupuncture also showed more effective at total efficiency. The more adverse effect occurred in the acupuncture group when comparing with the dicetel group ( RR = 11.86 , 95% CI [1.58, 89.07]) and loperamide group ( RR = 4.42 , 95% CI [0.57, 33.97]), but most of the adverse reactions were mild hypodermic hemorrhage. Conclusion. Acupuncture treatment can improve the clinical effectiveness of IBS-D or FD, with great safety, but the above conclusions need to be further verified through the higher quality of evidence.

scholarly journals Functional Constipation and Constipation-Predominant Irritable Bowel Syndrome in the General Population: Data from the GECCO Study

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Paul Enck ◽  
Johannes Leinert ◽  
Menno Smid ◽  
Thorsten Köhler ◽  
Juliane Schwille-Kiuntke
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Physical Health ◽  
Clinical Characteristics ◽  
Functional Constipation ◽  
German Population ◽  
Rome Criteria ◽  
Health Domain ◽  
Irritable Bowel

Background. The prevalence of constipation in the (German) population has been shown to be 14.9% in a telephone survey, but more detailed data are required to characterize the sociographics and clinical characteristics of persons with different types of functional constipation, either constipation-predominant irritable bowel syndrome (IBS-C) or functional constipation with or without meeting Rome criteria.Methods. Of 2239 constipated individuals identified during the telephone interview, 1037 (46.3%) were willing to provide a postal address for a questionnaire, of which 589 (56.8%) returned the questionnaire, inquiring about sociographic data, clinical symptoms, and health care behavior related to constipation, as well as health-related quality-of-life (SF12). Subgroups of functionally constipated individuals were compared.Results. More than 50% of the respondents reported a somatic comorbid condition and/or regular medication intake that may contribute to constipation. We split the remaining individuals (N=214) into three groups, matching Rome-criteria for IBS (IBS-C,n=64) and for functional constipation (FC-R,n=36) and FC not matching Rome criteria (n=114). Nearly all sociographic and clinical characteristics were equal among them, and all individuals with constipation had similar and lowered QOL on the SF-12 physical health domain, but in IBS-C the scores were also significantly lower in comparison to FC-R and FC, in both the physical health and the mental health domain.Conclusion. Only a fraction of individuals with chronic constipation match Rome criteria for IBS-C or FC, but subgroups do not differ with respect to most other measures except quality-of-life profiles.

Impact of functional bowel symptoms on quality of life and fatigue in quiescent Crohn disease and irritable bowel syndrome

2010 ◽  
Vol 22 (6) ◽  
pp. 626-e174 ◽  
Author(s):  
T. Piche ◽  
P. Ducrotté ◽  
J. M. Sabate ◽  
B. Coffin ◽  
F. Zerbib ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Crohn Disease ◽  
Bowel Symptoms ◽  
Irritable Bowel

scholarly journals The impact of abuse and mood on bowel symptoms and health-related quality of life in irritable bowel syndrome (IBS)

2016 ◽  
Vol 28 (10) ◽  
pp. 1508-1517 ◽  
Author(s):  
N. Kanuri ◽  
B. Cassell ◽  
S. E. Bruce ◽  
K. S. White ◽  
B. M. Gott ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Health Related Quality ◽  
Bowel Symptoms ◽  
Related Quality ◽  
Health Related ◽  
Irritable Bowel ◽  
The Impact
Sign in / Sign up

Export Citation Format

Share Document