Mortality in Eosinophilic Esophagitis – a nationwide, population-based matched cohort study from 2005 to 2017

Background: There is a lack of knowledge about mortality in eosinophilic esophagitis (EoE). Therefore, this study aimed to examine the mortality in EoE. Methods: A nationwide, population-based matched cohort study was conducted of all EoE patients in Sweden diagnosed between July 2005 and December 2017. Individuals with EoE (n = 1,625) were identified through prospectively recorded histopathology codes from all gastrointestinal pathology reports in Sweden, representing 28 pathology departments (the ESPRESSO study). Each individual with EoE was then matched with up to five reference individuals from the general population (n = 8,003) for age, sex, year of birth, and place of residence. We used the Cox proportional hazard modeling to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (95% CI) while adjusting for other potential confounders. In sensitivity analyses, mortality in EoE patients was compared with mortality in their siblings. Results: Through December 2017, 34 deaths were confirmed in EoE patients (4.60 per 1,000 person-years) compared with 165 in reference individuals (4.57 per 1,000 person-years). This rate corresponds to an aHR of 0.97 (95% CI = 0.67–1.40). HRs were similar in males (aHR = 1.00 [0.66–1.51]) and females (aHR = 0.92 [0.38–2.18]). We observed no increased risk in mortality due to esophageal or other gastrointestinal cancers in patients with EoE (aHR = 1.02 [0.51–2.02]). Mortality was similar in EoE patients and their siblings (aHR = 0.91 [0.44–1.85]). Conclusion: In this nationwide, population-based matched cohort study in Sweden, there was no increased risk of death in patients with EoE compared with their siblings and the general population.

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Re: Association of Overlapping Surgery with Increased Risk for Complications following Hip Surgery: A Population-Based, Matched Cohort Study

The Journal of Urology ◽

10.1016/j.juro.2018.02.052 ◽

2018 ◽

Vol 199 (5) ◽

pp. 1102-1104

Author(s):

Matthew J. Resnick

Keyword(s):

Cohort Study ◽

Population Based ◽

Hip Surgery ◽

Matched Cohort ◽

Matched Cohort Study ◽

Increased Risk

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Increased risk of adhesive capsulitis among patients with gout: A nationwide population-based matched-cohort study

International Journal of Rheumatic Diseases ◽

10.1111/1756-185x.13347 ◽

2018 ◽

Vol 21 (9) ◽

pp. 1716-1722 ◽

Cited By ~ 1

Author(s):

Kao-Chih Hsu ◽

Chia-Hung Sun ◽

Yin-Yin Wu ◽

Liang-Cheng Chen ◽

Yung-Tsan Wu ◽

...

Keyword(s):

Cohort Study ◽

Adhesive Capsulitis ◽

Population Based ◽

Matched Cohort ◽

Matched Cohort Study ◽

Increased Risk

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Differential cerebrovascular risks in glioblastoma and meningioma patients: a population-based matched cohort study in Wales (United Kingdom)

Neuro-Oncology ◽

10.1093/neuonc/noab195.028 ◽

2021 ◽

Vol 23 (Supplement_4) ◽

pp. iv12-iv12

Author(s):

Michael T C Poon ◽

Kai Jin ◽

Paul M Brennan ◽

Jonine Figueroa ◽

Cathie Sudlow

Keyword(s):

Cohort Study ◽

General Population ◽

Ischaemic Stroke ◽

Population Based ◽

Parametric Models ◽

Matched Cohort ◽

Matched Cohort Study ◽

Hazard Ratios ◽

History Of

Abstract Aims There is limited evidence on cerebrovascular risks in glioblastoma and meningioma patients. We aimed to compare cerebrovascular risks of these patients with the general population. Method We used population-based routine healthcare and administrative data linkage in this matched cohort study. Cases were adult glioblastoma and meningioma patients diagnosed in Wales 2000-2014 identified in the cancer registry. Controls from cancer-free general population were matched to cases (5:1 ratio) on age (±5 years), sex and GP practice. Factors included in multivariable models were age, sex, index of multiple deprivation, hypertension, diabetes, high cholesterol, history of cardiovascular disease, and medications for cardiovascular diseases. Outcomes were fatal and non-fatal haemorrhagic and ischaemic stroke. We used flexible parametric models adjusting for confounders to calculate the hazard ratios (HR). Results Final analytic population was 16,921 participants, of which 1,340 had glioblastoma and 1,498 had meningioma. The median follow-up time was 0.5 year for glioblastoma patients, 4.9 years for meningioma patients, and 6.6 years for controls. The number of haemorrhage and ischaemic stroke was 154 and 374 in the glioblastoma matched cohort, respectively, and 180 and 569 in the meningioma matched cohort, respectively. The adjusted HRs for haemorrhagic and ischaemic stroke were 3.74 (95%CI 1.87-6.57) and 5.62 (95%CI 2.56-10.42) in glioblastoma patients, respectively, and were 2.42 (95%CI 1.58-3.52) and 1.86 (95%CI 1.54-2.23) in meningioma patients compared with their controls. Conclusion Glioblastoma and meningioma patients had higher cerebrovascular risks; these risks were even higher for glioblastoma patients. Further assessment of these potentially modifiable risks may improve survivorship.

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Is weight control surgery associated with increased risk of newly onset psychiatric disorders? A population-based, matched cohort study in Taiwan

Journal of Medical Sciences ◽

10.4103/jmedsci.jmedsci_94_16 ◽

2017 ◽

Vol 37 (4) ◽

pp. 137 ◽

Cited By ~ 7

Author(s):

Nian-Sheng Tzeng ◽

Wu-Chien Chien ◽

Chi-Hsiang Chung ◽

Fu-Huang Lin ◽

Hsin-An Chang ◽

...

Keyword(s):

Cohort Study ◽

Psychiatric Disorders ◽

Weight Control ◽

Population Based ◽

Matched Cohort ◽

Matched Cohort Study ◽

Increased Risk

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Increased risk of osteoporotic fractures in Swedish patients with rheumatoid arthritis despite early treatment with potent disease-modifying anti-rheumatic drugs: a prospective general population-matched cohort study

Scandinavian Journal of Rheumatology ◽

10.1080/03009742.2019.1611918 ◽

2019 ◽

Vol 48 (6) ◽

pp. 431-438 ◽

Cited By ~ 1

Author(s):

BM Nyhäll-Wåhlin ◽

S Ajeganova ◽

IF Petersson ◽

MLE Andersson

Keyword(s):

Rheumatoid Arthritis ◽

Cohort Study ◽

General Population ◽

Early Treatment ◽

Osteoporotic Fractures ◽

Matched Cohort ◽

Matched Cohort Study ◽

Increased Risk ◽

Disease Modifying

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Increased risk of rheumatoid arthritis in patients with migraine: a population-based, propensity score-matched cohort study

Rheumatology International ◽

10.1007/s00296-016-3604-2 ◽

2016 ◽

Vol 37 (2) ◽

pp. 273-279 ◽

Cited By ~ 9

Author(s):

Yi-Chia Wang ◽

Ya-Ping Huang ◽

Mei-Ting Wang ◽

Hsin-I Wang ◽

Shin-Liang Pan

Keyword(s):

Rheumatoid Arthritis ◽

Cohort Study ◽

Propensity Score ◽

Population Based ◽

Matched Cohort ◽

Matched Cohort Study ◽

Increased Risk

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Increased risk of arrhythmia in patients with psoriatic disease: A nationwide population-based matched cohort study

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2015.06.023 ◽

2015 ◽

Vol 73 (3) ◽

pp. 429-438 ◽

Cited By ~ 27

Author(s):

Hsien-Yi Chiu ◽

Wei-Lun Chang ◽

Weng-Foung Huang ◽

Yu-Wen Wen ◽

Yi-Wen Tsai ◽

...

Keyword(s):

Cohort Study ◽

Population Based ◽

Matched Cohort ◽

Matched Cohort Study ◽

Psoriatic Disease ◽

Increased Risk

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Increased risk of avascular necrosis in patients with psoriatic disease: A nationwide population-based matched cohort study

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2016.11.001 ◽

2017 ◽

Vol 76 (5) ◽

pp. 903-910.e1 ◽

Cited By ~ 4

Author(s):

Hsien-Yi Chiu ◽

I-Ting Wang ◽

Weng-Foung Huang ◽

Yi-Wen Tsai ◽

Ming-Neng Shiu ◽

...

Keyword(s):

Cohort Study ◽

Avascular Necrosis ◽

Population Based ◽

Matched Cohort ◽

Matched Cohort Study ◽

Psoriatic Disease ◽

Increased Risk

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Excess Mortality Among Hospitalized Patients With Hypopituitarism—A Population-Based, Matched-Cohort Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgaa517 ◽

2020 ◽

Vol 105 (11) ◽

Author(s):

Fahim Ebrahimi ◽

Alexander Kutz ◽

Ulrich Wagner ◽

Ben Illigens ◽

Timo Siepmann ◽

...

Keyword(s):

Cohort Study ◽

Hospital Mortality ◽

Clinical Outcomes ◽

Excess Mortality ◽

Population Based ◽

Hospitalized Patients ◽

Matched Cohort ◽

Prolonged Length ◽

Matched Cohort Study ◽

Increased Risk

Abstract Context Patients with hypopituitarism face excess mortality in the long-term outpatient setting. However, associations of pituitary dysfunction with outcomes in acutely hospitalized patients are lacking. Objective The objective of this work is to assess clinical outcomes of hospitalized patients with hypopituitarism with or without diabetes insipidus (DI). Design, Setting, and Patients In this population-based, matched-cohort study from 2012 to 2017, hospitalized adult patients with a history of hypopituitarism were 1:1 propensity score–matched with a general medical inpatient cohort. Main Outcome Measures The primary outcome was in-hospital mortality. Secondary outcomes included all-cause readmission rates within 30 days and 1 year, intensive care unit (ICU) admission rates, and length of hospital stay. Results After matching, 6764 cases were included in the study. In total, 3382 patients had hypopituitarism and of those 807 (24%) suffered from DI. All-cause in-hospital mortality occurred in 198 (5.9%) of patients with hypopituitarism and in 164 (4.9%) of matched controls (odds ratio [OR] 1.32, [95% CI, 1.06-1.65], P = .013). Increased mortality was primarily observed in patients with DI (OR 3.69 [95% CI, 2.44-5.58], P < .001). Patients with hypopituitarism had higher ICU admissions (OR 1.50 [95% CI, 1.30-1.74], P < .001), and faced a 2.4-day prolonged length of hospitalization (95% CI, 1.94–2.95, P < .001) compared to matched controls. Risk of 30-day (OR 1.31 [95% CI, 1.13-1.51], P < .001) and 1-year readmission (OR 1.29 [95% CI, 1.17-1.42], P < .001) was higher among patients with hypopituitarism as compared with medical controls. Conclusions Patients with hypopituitarism are highly vulnerable once hospitalized for acute medical conditions with increased risk of mortality and adverse clinical outcomes. This was most pronounced among those with DI.

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