Host Genetics of HIV-1/AIDS Infection

2010 ◽  
pp. 305-305
Author(s):  
Narinder Mehra ◽  
Gurvinder Kaur
Keyword(s):  
Host Genetics ◽  
Hiv 1

Immunodominance of HIV-1-specific CD8+ T-cell responses in acute HIV-1 infection: at the crossroads of viral and host genetics

2005 ◽  
Vol 26 (3) ◽  
pp. 166-171 ◽  
Author(s):  
Mathias Lichterfeld ◽  
Xu G. Yu ◽  
Sylvie Le Gall ◽  
Marcus Altfeld
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Host Genetics ◽  
Cell Responses ◽  
Acute Hiv ◽  
Hiv 1

scholarly journals Host genetic associations with the gut microbiota in HIV-1-infected subjects: a pilot exploratory study

2018 ◽  
Author(s):  
Yolanda Guillén ◽  
Marc Noguera-Julian ◽  
Javier Rivera ◽  
Maria Casadellà ◽  
Muntsa Rocafort ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Methanogenic Archaea ◽  
Genetic Associations ◽  
Host Genetics ◽  
Genetic Landscape ◽  
Host Genetic ◽  
Gene Richness ◽  
The Impact ◽  
Hiv 1

AbstractThe impact of host genetics on gut microbial dynamics is debated. No study to date has investigated the possible role of host genetics in shaping the gut microbiota in HIV-1 infected subjects. With the aim of generating preliminary data to inform future host genetic studies, we performed an exploratory host exome analysis of 147 subjects either infected or at risk of becoming infected with HIV-1 from the MetaHIV cohort in Barcelona. Using a DNA microarray chip, we sought to identify host genetic variants associated to three specific microbial features with a potentially inheritable component, and which were previously found to be associated with gut dysbiosis in HIV infection, i.e.: gut enterotype, presence of methanogenic archaea and microbial gene richness. After correction for multiple comparisons, we did not observe any statistically significant association between the host’s genetic landscape and the explored gut microbiome traits. These findings will help design future, adequately-powered studies to assess the influence of host genetics in the microbiome of HIV-1-infected subjects.

scholarly journals Host genetics and HIV-1 viral load set-point in African–Americans

AIDS ◽  
2009 ◽  
Vol 23 (6) ◽  
pp. 673-677 ◽  
Author(s):  
Sadeep Shrestha ◽  
Brahim Aissani ◽  
Wei Song ◽  
Craig M Wilson ◽  
Richard A Kaslow ◽  
...  
Keyword(s):  
Viral Load ◽  
African Americans ◽  
Host Genetics ◽  
Set Point ◽  
Viral Load Set Point ◽  
Hiv 1

scholarly journals Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome

AIDS ◽  
2009 ◽  
Vol 23 (2) ◽  
pp. 259-262 ◽  
Author(s):  
Hendrik Streeck ◽  
Heiko Jessen ◽  
Claudia Kuecherer ◽  
Bin Li ◽  
Arne B Jessen ◽  
...  
Keyword(s):  
Host Genetics ◽  
Virological Outcome ◽  
The Impact ◽  
Hiv 1

scholarly journals Behavioral Risk Exposure and Host Genetics of Susceptibility to HIV‐1 Infection

2006 ◽  
Vol 193 (1) ◽  
pp. 16-26 ◽  
Author(s):  
Sadeep Shrestha ◽  
Steffanie A. Strathdee ◽  
Noya Galai ◽  
Taras Oleksyk ◽  
M. Daniele Fallin ◽  
...  
Keyword(s):  
Risk Exposure ◽  
Behavioral Risk ◽  
Host Genetics ◽  
Hiv 1

scholarly journals Whole Genome Rare-Variant Association Study of HIV-1 Progression in a Southern African Population

2020 ◽  
Author(s):  
Prisca K. Thami ◽  
Wonderful Choga ◽  
Delesa D. Mulisa ◽  
Collet Dandara ◽  
Andrey K. Shevchenko ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Rare Variant ◽  
Rare Variants ◽  
Variant Calling ◽  
Analysis Tool ◽  
Whole Genome ◽  
Host Genetics ◽  
Hiv 1

ABSTRACTDespite the high burden of HIV-1 in Botswana, the population of Botswana is significantly underrepresentation in host genetics studies of HIV-1. Furthermore, the bulk of previous genomics studies evaluated common human genetic variations, however, there is increasing evidence of the influence of rare variants in the outcome of diseases which may be uncovered by comprehensive complete and deep genome sequencing. This research aimed to evaluate the role of rare-variants in susceptibility to HIV-1 and progression through whole genome sequencing. Whole genome sequences (WGS) of 265 HIV-1 positive and 125 were HIV-1 negative unrelated individuals from Botswana were mapped to the human reference genome GRCh38. Population joint variant calling was performed using Genome Analysis Tool Kit (GATK) and BCFTools. Cumulative effects of rare variant sets on susceptibility to HIV-1 and progression (CD4+ T-cell decline) were determined with optimized Sequence Kernel Association Test (SKAT-O). In silico functional analysis of the prioritized variants was performed through gene-set enrichment using databases in GeneMANIA and Enrichr. Novel rare-variants within the ANKRD39 (8.48 × 10−8), LOC105378523 (7.45 × 10−7) and GTF3C3 (1.36 × 10−6) genes were significantly associated with HIV-1 progression. Functional analysis revealed that these genes are involved in viral translation and transcription. These findings highlight the significance of whole genome sequencing in pinpointing rare-variants of clinical relevance. The research contributes towards a deeper understanding of the host genetics HIV-1 and offers promise of population specific interventions against HIV-1.

Host Genetics and Resistance to HIV-1 Infection

2012 ◽  
pp. 169-209 ◽  
Author(s):  
Ma Luo ◽  
Paul J. McLaren ◽  
Francis A. Plummer
Keyword(s):  
Host Genetics ◽  
Hiv 1

scholarly journals Could the CCR5-Δ32 Mutation be Protective in SARS-CoV-2 Infection?

2021 ◽  
pp. S249-S252
Author(s):  
N STARČEVIĆ ČIZMAREVIĆ ◽  
M KAPOVIĆ ◽  
D RONČEVIĆ ◽  
S RISTIĆ
Keyword(s):  
Viral Infections ◽  
Allelic Frequency ◽  
European Population ◽  
Host Responses ◽  
Host Genetics ◽  
Ecologic Study ◽  
The Impact ◽  
Hiv 1 ◽  
Pandemic Wave

Increasing evidence points to host genetics as a factor in COVID-19 prevalence and outcome. CCR5 is a receptor for proinflammatory chemokines that are involved in host responses, especially to viruses. The CCR5-Δ32 minor allele is an interesting variant, given the role of CCR5 in some viral infections, particularly HIV-1. Recent studies of the impact of CCR5-Δ32 on COVID-19 risk and severity have yielded contradictory results. This ecologic study shows that the CCR5-Δ32 allelic frequency in a European population was significantly negatively correlated with the number of COVID-19 cases (p=0.035) and deaths (p=0.006) during the second pandemic wave. These results suggest that CCR5-Δ32 may be protective against SARS-CoV-2 infection, as it is against HIV infection, and could be predictive of COVID-19 risk and severity. Further studies based on samples from populations of different genetic backgrounds are needed to validate these statistically obtained findings.

scholarly journals Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions

2014 ◽  
Vol 133 (9) ◽  
pp. 1187-1197 ◽  
Author(s):  
Xuelin Li ◽  
◽  
Matthew A. Price ◽  
Dongning He ◽  
Anatoli Kamali ◽  
...  
Keyword(s):  
Viral Load ◽  
Host Genetics ◽  
Hiv 1

scholarly journals HIV-1 evolution, drug resistance, and host genetics: The Indian scenario

2009 ◽  
Vol Volume 1 ◽  
pp. 1-4 ◽  
Author(s):  
U. Shankarkumar ◽  
Aruna Pawar ◽  
Kanjaksha Ghosh
Keyword(s):  
Drug Resistance ◽  
Host Genetics ◽  
Hiv 1 ◽  
Indian Scenario
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