scholarly journals Biochemical effects and safety of Gum arabic (Acacia Senegal) supplementation in patients with sickle cell anemia

2019 ◽  
Vol 54 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Lamis AbdelGadir Kaddam ◽  
Imad Fdl-Elmula ◽  
Omer Ali Eisawi ◽  
Haydar Awad Abdelrazig ◽  
Mustafa Khidir Elnimeiri ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Gum Arabic ◽  
Acacia Senegal ◽  
Biochemical Effects

scholarly journals Effect of Gum Arabic (Acacia Senegal )on C-reactive protein level among Sickle Cell Anemia patients

2020 ◽  
Author(s):  
Lamis AbdelGadir Kaddam ◽  
Anas Suliman Kaddam
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Protein Level ◽  
Daily Intake ◽  
Gum Arabic ◽  
Fetal Hemoglobin ◽  
C Reactive Protein ◽  
Acacia Senegal ◽  
Reactive Protein ◽  
Anti Inflammatory

Abstract Objectives: Inflammation is ongoing process among sickle cell anemia even during steady state. C reactive protein (CRP) is cardinal marker that utilized widely as inflammatory indicator. Gum Arabic (GA) is gummy exudates from Acacia Senegal tree. Fermentation by colonic bacteria increases serum butyrate concentrations, so considered as prebiotic agent. Gum Arabic (GA) has anti-inflammatory activity through butyrate. Earlier we proved that regular intake of GA increased fetal hemoglobin and anti-oxidant capacity most likely through raised level of butyrate, which would ameliorate symptoms of sickle cell anemia. Best of our knowledge this is the first study conducted to investigate GA intake on inflammatory markers among sickle patients.Results : This was a retrospective study conducted on stored samples from trial of Gum Arabic and sickle cell anemia. Quantitative CRP was measured by Mindray BS 200 before and after Gum Arabic consumption for 12 weeks. Daily intake of GA significantly decreased C reactive protein level (P.V=001) (95% CI, 0.943 -3.098). No correlation between CRP and age, fetal hemoglobin, hemolysis markers and white blood cells. Our findings revealed novel effect of GA as anti-inflammatory agent can be consumed as natural dietary supplement to modulate disease severity and downregulate inflammatory process.Trial registration: ClinicalTrials.gov Identifier: NCT02467257. Registered 3rd June 2015

Effect of Gum Arabic (Acacia Senegal )on C-reactive protein level among Sickle Cell Anemia patients

2020 ◽  
Author(s):  
Lamis AbdelGadir Kaddam ◽  
Anas Suliman Kaddam
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Protein Level ◽  
Daily Intake ◽  
Gum Arabic ◽  
Fetal Hemoglobin ◽  
C Reactive Protein ◽  
Acacia Senegal ◽  
Reactive Protein ◽  
Anti Inflammatory

Abstract Objectives: Inflammation is ongoing process among sickle cell anemia even during steady state. C reactive protein (CRP) is cardinal marker that utilized widely as inflammatory indicator. Gum Arabic (GA) is gummy exudates from Acacia Senegal tree. Fermentation by colonic bacteria increases serum butyrate concentrations, so considered as prebiotic agent. Gum Arabic (GA) has anti-inflammatory activity through butyrate. Earlier we proved that regular intake of GA increased fetal hemoglobin and anti-oxidant capacity most likely through raised level of butyrate, which would ameliorate symptoms of sickle cell anemia. Best of our knowledge this is the first study conducted to investigate GA intake on inflammatory markers among sickle patients. Results : This was a retrospective study conducted on stored samples from trial of Gum Arabic and sickle cell anemia. Quantitative CRP was measured by Mindray BS 200 before and after Gum Arabic consumption for 12 weeks. Daily intake of GA significantly decreased C reactive protein level (P.V=001) (95% CI, 0.943 -3.098). No correlation between CRP and age, fetal hemoglobin, hemolysis markers and white blood cells. Our findings revealed novel effect of GA as anti-inflammatory agent can be consumed as natural dietary supplement to modulate disease severity and downregulate inflammatory process.

scholarly journals Acacia Senegal (Gum Arabic) Supplementation Modulate Lipid Profile and Ameliorated Dyslipidemia among Sickle Cell Anemia Patients

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Lamis Kaddam ◽  
Imad Fadl-Elmula ◽  
Omer Ali Eisawi ◽  
Haydar Awad Abdelrazig ◽  
Amal M. Saeed
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Density Lipoprotein ◽  
Gum Arabic ◽  
Oxidative Stress Marker ◽  
Acacia Senegal ◽  
Baseline Serum

Background. Sickle cell disease (SCD) is an inherited haemolytic anemia with a variable course and severity. Knowledge of prognostic biomarkers may help in the establishment of therapeutic intervention, management, and follow-up of patients. There have been scattered reports of low high-density lipoprotein cholesterol (HDL-C) and increased triglyceride (TG) in SCD patients. In addition, TG levels have been suggested to be elevated in patients with increased endothelial activation. An increased TG level has been associated with haemolysis, vascular dysfunction, and increased prevalence of pulmonary hypertension. Gum Arabic (GA) is an edible, dried, gummy exudate from the acacia Senegal tree. Several studies on GA ingestion have shown reduced plasma cholesterol and low-density lipoprotein (LDL) concentrations in both animals and humans. We investigated GA’s therapeutic potential to modulate serum lipids in patients with sickle cell anemia.Methods. This study recruited and documented secondary outcomes in 47 patients (aged 5–42 years) carrying hemoglobin SS. The patients received 30 g/day of GA for 12 weeks. Total cholesterol, TG, LDL, and HDL were measured before and after GA intake. Cobas C311 (Roche, Germany) automated chemistry analyser was used for direct determination of the values of the lipid profile.Results. GA significantly decreased total cholesterol (TC), TG, and LDL (p= 0.006, 0.04, and 0.02, resp.). GA showed no effect on HDL level. Baseline serum TG and LDL correlated significantly with the hydrogen peroxide (H2O2) level, which is known as an oxidative stress marker (p= 0.003 and 0.04, resp.). None of the lipid profile elements correlated with age.Conclusion. Our results revealed that dyslipidemia in sickle cell patients is associated with oxidative stress but not associated with age. The findings showed that GA significantly decreased TC, LDL, and TG levels, revealing a novel effect of GA, which is considered a natural dietary fibre that can modulate lipid profile in patients with sickle cell anemia.Trial Registration. This retrospective trial is registered with ClinicalTrials.gov Identifier:NCT02467257on 3 June, 2015.

scholarly journals Gum Arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Lamis Kaddam ◽  
Imad Fadl-Elmula ◽  
Omer Ali Eisawi ◽  
Haydar Awad Abdelrazig ◽  
Mohammed Abdelraman Salih ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Phase Ii ◽  
Sickle Cell Anemia ◽  
Phase Ii Trial ◽  
Gum Arabic ◽  
Anti Oxidant

scholarly journals Gum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; in vivo study

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Lamis Kaddam ◽  
Imad FdleAlmula ◽  
Omer Ali Eisawi ◽  
Haydar Awad Abdelrazig ◽  
Mustafa Elnimeiri ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Gum Arabic ◽  
Fetal Hemoglobin ◽  
In Vivo Study

The orientation of sickle hemoglobin fibers within fascicles

1988 ◽  
Vol 46 ◽  
pp. 400-401
Author(s):  
Christopher A. Miller ◽  
Bridget Carragher ◽  
William A. McDade ◽  
Robert Josephs
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Relative Orientation ◽  
Unit Cell ◽  
Red Cell ◽  
High Ph ◽  
Sickle Hemoglobin ◽  
Polar Crystal ◽  
Helical Configuration

Highly ordered bundles of deoxyhemoglobin S (HbS) fibers, termed fascicles, are intermediates in the high pH crystallization pathway of HbS. These fibers consist of 7 Wishner-Love double strands in a helical configuration. Since each double strand has a polarity, the odd number of double strands in the fiber imparts a net polarity to the structure. HbS crystals have a unit cell containing two double strands, one of each polarity, resulting in a net polarity of zero. Therefore a rearrangement of the double strands must occur to form a non-polar crystal from the polar fibers. To determine the role of fascicles as an intermediate in the crystallization pathway it is important to understand the relative orientation of fibers within fascicles. Furthermore, an understanding of fascicle structure may have implications for the design of potential sickling inhibitors, since it is bundles of fibers which cause the red cell distortion responsible for the vaso-occlusive complications characteristic of sickle cell anemia.

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