Discovery of Low-Molecular Weight Antagonists of Substance P: Recent Developments and Prospects as a Therapeutic Agent.

This perspective highlights the recent developments in the study of the photoluminescent properties of aryl–group eleven complexes. Related properties and applications such as electroluminescence, triboluminescence, mechanochromism, luminescent liquid crystals, low molecular weight gelators and photocatalysts are also discussed.

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Recent developments in low molecular weight complement inhibitors

Molecular Immunology ◽

10.1016/j.molimm.2009.08.032 ◽

2009 ◽

Vol 47 (2-3) ◽

pp. 185-195 ◽

Cited By ~ 78

Author(s):

Hongchang Qu ◽

Daniel Ricklin ◽

John D. Lambris

Keyword(s):

Molecular Weight ◽

Low Molecular Weight ◽

Complement Inhibitors ◽

Recent Developments

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Recent Developments in the Separation of Low Molecular Weight Heparin Anticoagulants

Current Medicinal Chemistry ◽

10.2174/0929867324666171005114150 ◽

2019 ◽

Vol 26 (1) ◽

pp. 166-176 ◽

Cited By ~ 4

Author(s):

Radosław Sadowski ◽

Renata Gadzała-Kopciuch ◽

Bogusław Buszewski

Keyword(s):

Molecular Weight ◽

Chemical Structure ◽

Blood Clotting ◽

Structural Complexity ◽

Analytical Techniques ◽

Low Molecular Weight ◽

General Function ◽

Low Molecular Weight Heparins ◽

Recent Developments ◽

Medical Importance

The general function of anticoagulants is to prevent blood clotting and growing of the existing clots in blood vessels. In recent years, there has been a significant improvement in developing methods of prevention as well as pharmacologic and surgical treatment of thrombosis. For over the last two decades, low molecular weight heparins (LMWHs) have found their application in the antithrombotic diseases treatment. These types of drugs are widely used in clinical therapy. Despite the biological and medical importance of LMWHs, they have not been completely characterized in terms of their chemical structure. Due to both, the structural complexity of these anticoagulants and the presence of impurities, their structural characterization requires the employment of advanced analytical techniques. Since separation techniques play the key role in these endeavors, this review will focus on the presentation of recent developments in the separation of LMWH anticoagulants.

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Antitumour Activity of Dehydroxymethylepoxyquinomycin (DHMEQ): a Literature Review

Creative Surgery and Oncology ◽

10.24060/2076-3093-2021-11-1-68-75 ◽

2021 ◽

Vol 11 (1) ◽

pp. 68-75

Author(s):

K. Umezawa ◽

Sh. Kh. Gantsev ◽

Sh. R. Kzyrgalin ◽

R. S. Yamidanov ◽

R. A. Amirov ◽

...

Keyword(s):

Molecular Weight ◽

Therapeutic Agent ◽

Antitumour Activity ◽

Low Molecular Weight ◽

Malignant Cells ◽

Apoptosis Inhibition ◽

Promising Target ◽

Anti Cancer ◽

Apoptosis And Inflammation ◽

Dependent Pathway

Carcinogenesis research uncovers new pathogenesis links as vulnerable targets of effective antitumour therapies. Among the key mediators of immune response, cell proliferation, cell apoptosis and inflammation is transcription factor NF-κB. Misregulation of an NF-κB-dependent pathway is found in solid and haematopoietic tumour cells. One of the best known NF-κB functions is expression regulation of genes involved in the apoptosis inhibition or activation and survival in both intact and malignant cells. The NF-κB-mediated pathways’ involvement in carcinogenesis, angiogenesis and tumour resistance to chemo- and radiotherapies makes this factor a promising target for drug anti-cancer interventions. This review summarises evidence on the antitumour and anti-inflammatory activity of a high-potent and specific low molecular-weight NF-κB inhibitor, dehydroxymethylhepoxyquinomycin (DHMEQ), as a candidate therapeutic agent in treatment for variant malignancies.

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A high-performance oil-free backing pump for electron microscopes

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100107691 ◽

1978 ◽

Vol 36 (1) ◽

pp. 110-111

Author(s):

G.K.W. Balkau ◽

E. Bez ◽

J.L. Farrant

Keyword(s):

Molecular Weight ◽

Electron Microscope ◽

Hot Spots ◽

High Performance ◽

Carbonaceous Material ◽

Contamination Rate ◽

Low Molecular Weight ◽

Principal Source ◽

Rotary Pumps ◽

Electron Microscopes

The earliest account of the contamination of electron microscope specimens by the deposition of carbonaceous material during electron irradiation was published in 1947 by Watson who was then working in Canada. It was soon established that this carbonaceous material is formed from organic vapours, and it is now recognized that the principal source is the oil-sealed rotary pumps which provide the backing vacuum. It has been shown that the organic vapours consist of low molecular weight fragments of oil molecules which have been degraded at hot spots produced by friction between the vanes and the surfaces on which they slide. As satisfactory oil-free pumps are unavailable, it is standard electron microscope practice to reduce the partial pressure of organic vapours in the microscope in the vicinity of the specimen by using liquid-nitrogen cooled anti-contamination devices. Traps of this type are sufficient to reduce the contamination rate to about 0.1 Å per min, which is tolerable for many investigations.

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