scholarly journals A retrospective study on oral intake after surgery to prevent aspiration for amyotrophic lateral sclerosis （ALS）

2021 ◽  
Vol 31 (1) ◽  
pp. 1-6
Author(s):  
Satoshi Suzuki ◽  
Masao Asai
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Retrospective Study ◽  
Oral Intake ◽  
Lateral Sclerosis

scholarly journals A Retrospective Study of the Clinical Phenotype and Predictors of Survival in non-Caucasian Hispanic Patients with Amyotrophic Lateral Sclerosis.

2019 ◽  
Author(s):  
Claudia Marisol Sánchez-Martínez ◽  
José Alberto Choreño-Parra ◽  
Lilia Nuñez-Orozco ◽  
Noel Isaías Placencia-Álvarez ◽  
Laura Marcela Alvis-Cataño ◽  
...  
Keyword(s):  
Overall Survival ◽  
Amyotrophic Lateral Sclerosis ◽  
Prognostic Factors ◽  
Retrospective Study ◽  
Survival Time ◽  
Clinical Characteristics ◽  
Clinical Phenotype ◽  
Age At Onset ◽  
Als Patients ◽  
Lateral Sclerosis

Abstract Background. Little is known about the clinical phenotype of amyotrophic lateral sclerosis (ALS) in non-Caucasian populations. Here, we aimed to describe the clinical characteristics, prognostic factors and survival of Mexican patients with ALS. Methods. We conducted a retrospective study by reviewing the medical records of patients with ALS that attended and were regularly followed at a third level hospital in Mexico City from 2000 to 2015. We calculated absolute and relative frequencies of the clinical characteristics from all the participants. We also estimated correlation coefficients between clinical features and overall survival. Additionally, survival rates were compared for all participants grouped according to different clinical features using the Kaplan-Meier method and the log-rank test. Results. We enrolled 45 ALS patients, 53.33% had spinal-onset ALS and 46.66% presented bulbar ALS. The male/female ratio was 0.8. The mean age at onset of symptoms was 58.11 years. Mean survival time from onset was 64.73 ± 34.83 months. Cumulative survival rate after 5 years of disease onset was 44.44%. Age at onset and age at diagnosis inversely correlated with overall survival time. Also, we found that bulbar-onset, short diagnostic delay, percutaneous endoscopic gastrostomy, mechanical ventilation, and lower total cholesterol serum levels were associated with short survival. Conclusions. The clinical characteristics of Mexican ALS patients differ from the disease phenotype observed in Caucasians. Nonetheless, the predictive value of certain well-recognized prognostic factors remains consistent in our population. The current study provides relevant information for a better understanding of prognostic factors in ALS patients from Mexico and other Latin American countries.

Denervation findings on EMG in amyotrophic lateral sclerosis and correlation with prognostic milestones: Data from a retrospective study

2020 ◽  
Vol 131 (8) ◽  
pp. 2017-2022 ◽  
Author(s):  
E. Fileccia ◽  
S. De Pasqua ◽  
G. Rizzo ◽  
V. Di Stasi ◽  
V. Vacchiano ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Retrospective Study ◽  
Lateral Sclerosis

Stage-specific riluzole effect in amyotrophic lateral sclerosis: a retrospective study

2019 ◽  
Vol 21 (1-2) ◽  
pp. 140-143 ◽  
Author(s):  
Nimish J. Thakore ◽  
Brittany R. Lapin ◽  
Erik P. Pioro ◽  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Retrospective Study ◽  
Lateral Sclerosis

Decision-making for tracheostomy in amyotrophic lateral sclerosis (ALS): a retrospective study

2017 ◽  
Vol 18 (7-8) ◽  
pp. 492-497 ◽  
Author(s):  
Piero Ceriana ◽  
Sara Surbone ◽  
Daniele Segagni ◽  
Annia Schreiber ◽  
Annalisa Carlucci
Keyword(s):  
Decision Making ◽  
Amyotrophic Lateral Sclerosis ◽  
Retrospective Study ◽  
Lateral Sclerosis

scholarly journals Management of dysphagia in Parkinson's disease and amyotrophic lateral sclerosis

CoDAS ◽  
2013 ◽  
Vol 25 (4) ◽  
pp. 358-364 ◽  
Author(s):  
Karen Fontes Luchesi ◽  
Satoshi Kitamura ◽  
Lucia Figueiredo Mourão
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Disease Duration ◽  
Oral Intake ◽  
Therapeutic Approaches ◽  
Long Term Study ◽  
Adequate Food ◽  
Bolus Consistency ◽  
Tongue Control ◽  
Functional Oral Intake Scale ◽  
Lateral Sclerosis

PURPOSE: To describe swallowing management in patients with amyotrophic lateral sclerosis (ALS) and Parkinson' disease (PD), to investigate whether physiopathology determines the choice of therapeutic approaches, and to investigate whether the disease duration modifies the therapeutic approaches. METHODS: This is a long-term study comprising 24 patients with idiopathic PD and 27 patients with ALS. The patients were followed-up in a dysphagia outpatient clinic between 2006 and 2011. The patients underwent clinic evaluation and Fiberoptic Endoscopic Evaluation of Swallowing, Functional Oral Intake Scale, and therapeutic intervention every 3 months. The swallowing management was based on orientation about the adequate food consistency and volume, besides the necessary maneuvers or exercises to improve swallowing functionality. An exploratory analysis of data was used to investigate associations between the groups of disease (PD or ALS) and clinic aspects and to know about the association between the groups of diseases and the application of maneuver or exercises over the follow-up. RESULTS: The most frequent recommended maneuvers in PD were bolus effect (83.3%), bolus consistency (79.2%), and swallowing frequency (79%). To patients with ALS, the bolus consistency (92%) and the bolus effect (74.1%) were more recommended. Strengthening-tongue (p=0.01), tongue control (p=0.05), and vocal exercises (p<0.001) were significantly more recommended in PD than in ALS. CONCLUSION: Compensatory and sensorial maneuvers are more recommended to rehabilitee program in both diseases. The physiopathology of the diseases determined the choice of therapeutic approaches. The disease duration of the patients did not interfere directly in the therapeutic approaches.

scholarly journals A Retrospective Study of the Characteristics and Clinical Significance of A-Waves in Amyotrophic Lateral Sclerosis

2017 ◽  
Vol 8 ◽  
Author(s):  
Jia Fang ◽  
Liying Cui ◽  
Mingsheng Liu ◽  
Yuzhou Guan ◽  
Qingyun Ding ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Retrospective Study ◽  
Clinical Significance ◽  
Lateral Sclerosis

scholarly journals A retrospective study of the clinical phenotype and predictors of survival in non-Caucasian Hispanic patients with amyotrophic lateral sclerosis

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Claudia Marisol Sánchez-Martínez ◽  
José Alberto Choreño-Parra ◽  
Lilia Nuñez-Orozco ◽  
Noel Placencia-Álvarez ◽  
Laura Marcela Alvis-Castaño ◽  
...  
Keyword(s):  
Overall Survival ◽  
Amyotrophic Lateral Sclerosis ◽  
Prognostic Factors ◽  
Retrospective Study ◽  
Survival Time ◽  
Clinical Characteristics ◽  
Clinical Phenotype ◽  
Age At Onset ◽  
Als Patients ◽  
Lateral Sclerosis

Abstract Background Little is known about the clinical phenotype of amyotrophic lateral sclerosis (ALS) in non-Caucasian populations. Here, we aimed to describe the clinical characteristics, prognostic factors and survival of Mexican patients with ALS. Methods We conducted a retrospective study by reviewing the medical records of patients with ALS that attended and were regularly followed at a third level hospital in Mexico City from 2000 to 2015. We calculated absolute and relative frequencies of the clinical characteristics from all the participants. We also estimated correlation coefficients between clinical features and overall survival. Additionally, survival rates were compared for all participants grouped according to different clinical features using the Kaplan-Meier method and the log-rank test. Results We enrolled 45 ALS patients, 53.33% had spinal-onset ALS and 46.66% presented bulbar ALS. The male/female ratio was 0.8. The mean age at onset of symptoms was 58.11 years. Mean survival time from onset was 64.73 ± 34.83 months. Cumulative survival rate after 5 years of disease onset was 44.44%. Age at onset and age at diagnosis inversely correlated with overall survival time. Also, we found that bulbar-onset, short diagnostic delay, percutaneous endoscopic gastrostomy, mechanical ventilation, and lower total cholesterol serum levels were associated with short survival. Conclusions The clinical characteristics of Mexican ALS patients differ from the disease phenotype observed in Caucasians. Nonetheless, the predictive value of certain well-recognized prognostic factors remains consistent in our population. The current study provides relevant information for a better understanding of prognostic factors in ALS patients from Mexico and other Latin American countries.

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