scholarly journals Ameliorative effects of Moringa on cuprizone-induced memory decline in rat model of multiple sclerosis

2018 ◽  
Vol 51 (2) ◽  
pp. 119 ◽  
Author(s):  
Gabriel Olaiya Omotoso ◽  
Ismail Temitayo Gbadamosi ◽  
Theresa Titilayo Afolabi ◽  
Ahmad Bolakale Abdulwahab ◽  
Adelaja Abdulazeez Akinlolu
Keyword(s):  
Multiple Sclerosis ◽  
Rat Model ◽  
Memory Decline

Methylprednisolone improves lactate metabolism through reduction of elevated serum lactate in rat model of multiple sclerosis

2016 ◽  
Vol 84 ◽  
pp. 1504-1509 ◽  
Author(s):  
Majid Ghareghani ◽  
Amir Ghanbari ◽  
Shima Dokoohaki ◽  
Naser Farhadi ◽  
Seyed Mojtaba Hosseini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Rat Model ◽  
Elevated Serum ◽  
Serum Lactate ◽  
Lactate Metabolism

A Peptide Targeting Inflammatory CNS Lesions in the EAE Rat Model of Multiple Sclerosis

Inflammation ◽  
2018 ◽  
Vol 41 (3) ◽  
pp. 932-947 ◽  
Author(s):  
Claudine Boiziau ◽  
Macha Nikolski ◽  
Elodie Mordelet ◽  
Justine Aussudre ◽  
Karina Vargas-Sanchez ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Rat Model ◽  
Peptide Targeting ◽  
Cns Lesions

PET imaging of focal demyelination and remyelination in a rat model of multiple sclerosis: comparison of [11C]MeDAS, [11C]CIC and [11C]PIB

2014 ◽  
Vol 41 (5) ◽  
pp. 995-1003 ◽  
Author(s):  
Daniele de Paula Faria ◽  
Sjef Copray ◽  
Jurgen W. A. Sijbesma ◽  
Antoon T. M. Willemsen ◽  
Carlos A. Buchpiguel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pet Imaging ◽  
Rat Model ◽  
Focal Demyelination

Hippocampal volume is more related to patient-reported memory than objective memory performance in early multiple sclerosis

2020 ◽  
pp. 135245852092283
Author(s):  
Lisa Glukhovsky ◽  
Rachel Brandstadter ◽  
Victoria M Leavitt ◽  
Stephen Krieger ◽  
Korhan Buyukturkoglu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Memory Performance ◽  
Hippocampal Volume ◽  
Magnetic Resonance Images ◽  
Longitudinal Assessment ◽  
Subjective Memory ◽  
Cross Sectional ◽  
Memory Decline ◽  
Patient Reported ◽  
Partial Correlations

Background: When persons with multiple sclerosis (MS) report memory decline but objective memory performance is normal, there is a bias toward believing objective test results. Objective: Investigate whether subjective memory decline or objective memory performance is more related to hippocampal and hippocampal subfield volumes in early MS. Methods: Persons with early MS ( n = 185; ⩽5.0 years diagnosed) completed a subjective memory questionnaire; an objective memory composite was derived from four memory tests. Total hippocampal and subfield volumes were derived from high-resolution 3.0 T magnetic resonance images (MRIs). Partial correlations assessed links between hippocampal volumes and both subjective and objective memory, controlling for age, sex, mood, and pre-morbid intelligence quotient (IQ). Results: Lower total hippocampal and CA1 volumes were related to worse subjective memory but not objective memory (controlling for multiple comparisons). Correlations between subjective memory and both CA1 and subiculum were significantly stronger than were correlations between objective memory and these subfields. Patients in the worst tertile of subjective memory complaints (but not objective memory) had lower hippocampal volumes than 35 demographically similar healthy controls. Conclusion: Patient-report is inherently a longitudinal assessment of within-person memory change in everyday life, which may be more sensitive to subtle disease-related changes than cross-sectional objective tests. Findings align with the aging literature.

scholarly journals The radial diffusivity and magnetization transfer pool size ratio are sensitive markers for demyelination in a rat model of type III multiple sclerosis (MS) lesions

NeuroImage ◽  
2013 ◽  
Vol 74 ◽  
pp. 298-305 ◽  
Author(s):  
Vaibhav A. Janve ◽  
Zhongliang Zu ◽  
Song-Yi Yao ◽  
Ke Li ◽  
Fang Lin Zhang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Rat Model ◽  
Magnetization Transfer ◽  
Pool Size ◽  
Size Ratio ◽  
Radial Diffusivity ◽  
Type Iii
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