Hippocampal volume is more related to patient-reported memory than objective memory performance in early multiple sclerosis

2020 ◽  
pp. 135245852092283
Author(s):  
Lisa Glukhovsky ◽  
Rachel Brandstadter ◽  
Victoria M Leavitt ◽  
Stephen Krieger ◽  
Korhan Buyukturkoglu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Memory Performance ◽  
Hippocampal Volume ◽  
Magnetic Resonance Images ◽  
Longitudinal Assessment ◽  
Subjective Memory ◽  
Cross Sectional ◽  
Memory Decline ◽  
Patient Reported ◽  
Partial Correlations

Background: When persons with multiple sclerosis (MS) report memory decline but objective memory performance is normal, there is a bias toward believing objective test results. Objective: Investigate whether subjective memory decline or objective memory performance is more related to hippocampal and hippocampal subfield volumes in early MS. Methods: Persons with early MS ( n = 185; ⩽5.0 years diagnosed) completed a subjective memory questionnaire; an objective memory composite was derived from four memory tests. Total hippocampal and subfield volumes were derived from high-resolution 3.0 T magnetic resonance images (MRIs). Partial correlations assessed links between hippocampal volumes and both subjective and objective memory, controlling for age, sex, mood, and pre-morbid intelligence quotient (IQ). Results: Lower total hippocampal and CA1 volumes were related to worse subjective memory but not objective memory (controlling for multiple comparisons). Correlations between subjective memory and both CA1 and subiculum were significantly stronger than were correlations between objective memory and these subfields. Patients in the worst tertile of subjective memory complaints (but not objective memory) had lower hippocampal volumes than 35 demographically similar healthy controls. Conclusion: Patient-report is inherently a longitudinal assessment of within-person memory change in everyday life, which may be more sensitive to subtle disease-related changes than cross-sectional objective tests. Findings align with the aging literature.

Fear of memory decline predicts lower quality of life and increased memory failures in older adults: Preliminary findings from a novel fear-avoidance of memory decline scale.

2020 ◽  
Author(s):  
Francesca Farina ◽  
Marc Patrick Bennett ◽  
James William Griffith ◽  
Bert Lenaert
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Memory Performance ◽  
Fear Avoidance ◽  
Subjective Memory ◽  
Memory Decline ◽  
General Anxiety ◽  
Quality Of Life Scale ◽  
The Impact

Evidence concerning the impact of fear of memory decline on health-related outcomes is limited. To determine the relationship between fear-avoidance of memory decline, quality of life and subjective memory in older adults using a novel scale to measure fear of memory decline. Sixty-seven older adults (59-81 years) completed a 23-item self-report questionnaire designed to capture experiential, cognitive and behavioral components of fear of memory decline, known as the fear and avoidance of memory decline (FAM) scale. Memory performance was assessed using the Wechsler Memory Scale (WMS-IV) and the Memory Failures Scale (MFS). General anxiety was assessed using the Depression, Anxiety and Stress Scales (DASS) and the Geriatric Anxiety Inventory (GAI). Quality of life was assessed using the Older Person’s Quality of Life scale (OPQOL-35). The FAM scale demonstrated good reliability and validity. Three latent factors were observed including: (1) fear-avoidance, (2) problematic beliefs and (3) resilience. After adjusting for age, education, memory performance and general anxiety, higher fear-avoidance predicted lower quality of life (p=.021) and increased memory failures (p=.022). Increased fear of memory decline predicts lower quality of life and subjective memory failures in healthy older adults. Based on these findings, we propose a preliminary fear-avoidance model that explains the development and maintenance of dementia-related functional disability in terms of psychological processes.

Interrelations between Subjective Health and Episodic Memory Change in Swedish and Canadian Samples of Older Adults

2003 ◽  
Vol 57 (1) ◽  
pp. 21-35 ◽  
Author(s):  
Å Wahlin ◽  
Scott B. Maitland ◽  
Lars Bäckman ◽  
Roger A. Dixon
Keyword(s):  
Older Adults ◽  
Episodic Memory ◽  
Memory Performance ◽  
Subjective Health ◽  
Longitudinal Change ◽  
Subjective Memory ◽  
Cross Sectional ◽  
Memory Change ◽  
Two Samples ◽  
Kungsholmen Project

Recent research has documented associations between subjective health ratings and objective indicators of disease and death. Less is known about relations between subjective health ratings and level of cognitive performance in older adults. In this study, we explored whether subjective health ratings are related to episodic memory performance, both concurrently and across a three-year longitudinal interval. Persons aged 75–84 years, and participating in the Swedish Kungsholmen Project ( n = 105) or the Canadian Victoria Longitudinal Study ( n = 71), were examined. Results showed that in both samples, while the cross-sectional relationship was non-significant, longitudinal change in perceptions of subjective health were related to change in episodic memory performance. Next, the two samples were combined in additional analyses. Here, results further revealed that the associations between longitudinal change in subjective health and memory performance generalized across samples independently of demographic, changing physical health status, and subjective memory decline differences. Thus, the present findings suggest that subjective health may be added to the growing number of individual-difference variables that are predictive of episodic memory change in very old age.

scholarly journals Reducing survey burden: feasibility and validity of PROMIS measures in multiple sclerosis

2014 ◽  
Vol 20 (8) ◽  
pp. 1102-1111 ◽  
Author(s):  
Angela Senders ◽  
Douglas Hanes ◽  
Dennis Bourdette ◽  
Ruth Whitham ◽  
Lynne Shinto
Keyword(s):  
Multiple Sclerosis ◽  
Patient Reported Outcomes ◽  
Clinical Care ◽  
Good Evidence ◽  
Measurement Information ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Adaptive Tests ◽  
Patient Reported ◽  
Automatic Scoring

Background: Patient-reported outcomes are important for clinical research and care, yet administering and scoring the questionnaires requires considerable effort and time. The Patient Reported Outcomes Measurement Information System (PROMIS) could considerably reduce administrative obstacles and lessen survey burden for participants. Objective: Assess the feasibility and validity of PROMIS, compared to commonly-used legacy measures for multiple sclerosis (MS). Methods: In this cross-sectional survey, 133 participants with confirmed MS completed legacy surveys and PROMIS Computerized Adaptive Tests (CATs) for depression, anxiety, pain, fatigue and physical function. We conducted a multi-trait, multi-method analysis and verified results with confirmatory factor analysis. Results: The correlations between PROMIS and the corresponding legacy measures were large (0.67 to 0.87). The multi-trait, multi-method criteria were generally well met, providing good evidence of the validity of PROMIS measures. PROMIS surveys asked fewer questions and required substantially less time to complete than the legacy scales. Conclusions: Our results provide evidence of the construct validity of PROMIS for use with MS patients. Several aspects of the PROMIS CATs made them an important resource, including: (a) less time was required to complete them; (b) missing data was reduced; and (c) the automatic scoring referenced the general population. Our findings support the use of PROMIS in MS research and may have broader implications for clinical care, as well.

The longitudinal relationship between the patient-reported Multiple Sclerosis Impact Scale and the clinician-assessed Multiple Sclerosis Functional Composite

2007 ◽  
Vol 14 (2) ◽  
pp. 255-258 ◽  
Author(s):  
L. Costelloe ◽  
K. O'Rourke ◽  
C. McGuigan ◽  
C. Walsh ◽  
N. Tubridy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Important Change ◽  
Physical Change ◽  
Cross Sectional ◽  
Functional Composite ◽  
Multiple Sclerosis Functional Composite ◽  
Impact Scale ◽  
Patient Reported ◽  
Baseline Effect ◽  
Minimally Important Change

Background To examine the longitudinal relationship between the patient-rated Multiple Sclerosis Impact Scale (MSIS-29) and the doctor-reported Multiple Sclerosis Functional Composite (MSFC). Methods Two-hundred and four MS patients at baseline and 150 patients one to three years later had MSFC and MSIS-29 assessments. Cross-sectional correlations between these measures and correlations of change in scores were examined. Minimally important change (MIC) in the MSFC was defined at either 0.5 or 0.32 SD from baseline. Effect sizes (ES) were calculated. Results Validity: The MSIS-29 physical correlated moderately with the total MSFC score and the 25-foot timed walk and 9-hole peg test. Correlations of the MSIS-29 physical with the PASAT, and the MSFC with the MSIS-29 psychological were weak. Responsiveness: When MIC in the MSFC was defined as 0.5, mean MSIS-29 physical change was 11.26 (ES = 0.53). At MSFC change of 0.32, mean MSIS-29 physical change was 10.4 (ES = 0.52). Change in MSFC scores correlated weakly with change in the MSIS-29 scores. Stability: In patients with stable MSFC scores, the mean MSIS-29 physical scores improved minimally over time with negligible ES. Conclusions Although the MSIS-29 physical demonstrates moderate cross-sectional correlation with the MSFC, the weak correlations of change scores between the two instruments indicate that they measure different aspects of the effects of multiple sclerosis morbidity. Multiple Sclerosis 2008; 14: 255—258. http://msj.sagepub.com

scholarly journals The North American Registry for Care and Research in Multiple Sclerosis (NARCRMS)

2021 ◽  
Vol 23 (6) ◽  
pp. 269-275
Author(s):  
Kottil W. Rammohan ◽  
June Halper ◽  
Steven Lang ◽  
Sara McCurdy Murphy ◽  
Lisa Patton ◽  
...  
Keyword(s):  
United States ◽  
Multiple Sclerosis ◽  
Puerto Rico ◽  
Pharmaceutical Industry ◽  
North American ◽  
Patient Reported Outcomes ◽  
The United States ◽  
Magnetic Resonance Images ◽  
The North ◽  
Patient Reported

Abstract Although many regional multiple sclerosis (MS) databases existed in the United States and Canada, there was no single clinician-derived registry that examined this disease as a group across the North American continent. This distinction is important because information that results from such a database can potentially give perspectives about MS that cannot be derived from any single regional registry. A partnership was forged between the pharmaceutical industry and the Consortium of Multiple Sclerosis Centers (CMSC) to create a registry of patients with MS from Canada and the United States, including Puerto Rico. Case report forms were created to collect physician-derived information, and the Patient-Reported Outcomes Measurement Information System (PROMIS) was selected to capture patient-reported outcomes. As of November 2021, 754 of 1000 patients have been enrolled. Completion of recruitment is expected by the end of 2021. Twenty-five centers are participating, with an expected total of 30, including five centers from Canada. Clinical status, health economic outcomes, magnetic resonance images, and, soon, biomarkers relevant to understanding relapses and progression are collected. The short-term goal is to understand and better treat MS disease progression, and the long-term goal is its prevention. The North American Registry for Care and Research in Multiple Sclerosis (NARCRMS) is one of few clinician/patient-generated registries that examines MS across North America, including Puerto Rico. Information derived from the natural history studies should help physicians, the pharmaceutical industry, and regulatory bodies understand MS better and improve quality of life for patients with MS worldwide.

scholarly journals Relationship Between Interpersonal Deressive Symptoms and Reduced Amygdala Volume in People with Multiple Sclerosis: Considerations for Clinical Practice

2020 ◽  
Author(s):  
Sarah Haines ◽  
Ernest Butler ◽  
Stephen Stuckey ◽  
Robert Hester ◽  
Lisa B. Grech
Keyword(s):  
Multiple Sclerosis ◽  
Brain Atrophy ◽  
Depression Scale ◽  
Hippocampal Volume ◽  
Epidemiological Studies ◽  
Cross Sectional ◽  
Regional Brain ◽  
Amygdala Volume ◽  
The Right ◽  
Regional Brain Atrophy

Abstract Background: The lifetime prevalence of depression in people with multiple sclerosis (MS) is approximately 50% compared with around 16% in the general population. There is a relationship between depression and quality of life in people with MS and evidence that depression may contribute to disease progression. Methods: This cross-sectional pilot study assessed the association between depression and regional brain atrophy, including amygdala and hippocampal volume. Forty-nine participants with MS recruited through a hospital MS clinic were administered the Center for Epidemiological Studies Depression Scale Revised (CESD-R) to investigate whether higher endorsement on the items depressive affect and interpersonal symptoms were associated with volumetric magnetic resonance imaging measurements of hippocampal and amygdala atrophy. Results: Regression analysis revealed an association between depression-related interpersonal symptoms and right amygdala volume. No association was found between depression and hippocampal volume. Conclusions: These results provide preliminary support for a unilateral, biologically based relationship between the right amygdala and characteristic interpersonal depressive symptoms expressed by people with MS and add to the growing body of literature implicating regional brain atrophy in MS-associated depression. Given that the interpersonal subcomponent of the CESD-R measures social functioning, and the neural networks in the amygdala are known to be implicated in processing social stimuli, this research suggests that targeted diagnosis and treatments for depression in people with MS may be particularly beneficial in this population. Further confirmatory research of this relationship is required.

scholarly journals Reading, writing, and reserve: Literacy activities are linked to hippocampal volume and memory in multiple sclerosis

2016 ◽  
Vol 22 (12) ◽  
pp. 1621-1625 ◽  
Author(s):  
James F Sumowski ◽  
Maria A Rocca ◽  
Victoria M Leavitt ◽  
Gianna Riccitelli ◽  
Alessandro Meani ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Leisure Activities ◽  
Early Adulthood ◽  
Art Music ◽  
Hippocampal Volume ◽  
Evidence Based ◽  
Enrichment Programs ◽  
Memory Decline ◽  
Literacy Activities ◽  
Cognitive Activities

Background: Engagement in cognitive leisure activities during early adulthood has been linked to preserved memory and larger hippocampal volume in persons with multiple sclerosis (MS). Objective: To investigate which specific types of cognitive leisure activities contribute to hippocampal volume and memory. Methods: We investigated links between three types of cognitive activities (Reading-Writing, Art-Music, Games-Hobbies) and (a) hippocampal volume within independent samples of Italian (n=187) and American (n=55) MS patients and (b) memory in subsamples of Italian (n=97) and American (n=53) patients. Results: Reading-Writing was the only predictor of hippocampal volume (rp=.204, p=.002), and the best predictor of memory (rp=.288, p=.001). Conclusions: Findings inform the development of targeted evidence-based enrichment programs aiming to bolster reserve against memory decline.

scholarly journals Memory impairment in multiple sclerosis: Relevance of hippocampal activation and hippocampal connectivity

2015 ◽  
Vol 21 (13) ◽  
pp. 1705-1712 ◽  
Author(s):  
Hanneke E Hulst ◽  
Menno M Schoonheim ◽  
Quinten Van Geest ◽  
Bernard MJ Uitdehaag ◽  
Frederik Barkhof ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Memory Impairment ◽  
Memory Performance ◽  
Memory Function ◽  
Neuropsychological Test ◽  
Memory Task ◽  
Hippocampal Volume ◽  
Male Gender ◽  
Imaging Data ◽  
The Right

Background: Memory impairment is frequent in multiple sclerosis (MS), but it is unclear what functional brain changes underlie this cognitive deterioration. Objective: To investigate functional hippocampal activation and connectivity, in relation to memory performance in MS. Methods: Structural and functional magnetic resonance imaging data were acquired for 57 MS patients and 28 healthy controls (HCs), yielding hippocampal measures of volume, lesions, functional activation during a memory task and functional connectivity at rest. Memory function was based on two subtests of a larger neuropsychological test battery and related to hippocampal neuroimaging measures, using linear regression. Results: Hippocampal volume was lower in MS patients, as compared to HCs. In MS, hippocampal activation during the task was increased in cognitively preserved, but decreased in cognitively impaired, patients. Increased hippocampal connectivity was detected in MS patients, as compared to HCs, between the left hippocampus and the right posterior cingulate. Memory impairment in MS was explained (adjusted R2 = 0.27) by male gender, decreased hippocampal activation and increased hippocampal connectivity ( p = 0.001). Conclusions: Decreased activation of the hippocampus, increased connectivity and male gender were associated with worse memory performance in MS. These results indicate that increased activation and increased connectivity do not always coincide, and relate differently to cognitive dysfunction in MS.

scholarly journals Hippocampal Resting-State Functional Connectivity Patterns are More Closely Associated with Severity of Subjective Memory Decline than Whole Hippocampal and Subfield Volumes

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Lauren Zajac ◽  
Bang-Bon Koo ◽  
Yorghos Tripodis ◽  
Asim Mian ◽  
Eric Steinberg ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Hippocampal Volume ◽  
Cognitive Change ◽  
Imaging Data ◽  
Resting State Functional Connectivity ◽  
Subjective Memory ◽  
Memory Decline ◽  
Cognitively Normal ◽  
The Right

Abstract The goal of this study was to examine whether hippocampal volume or resting-state functional connectivity (rsFC) patterns are associated with subjective memory decline (SMD) in cognitively normal aged adults. Magnetic resonance imaging data from 53 participants (mean age: 71.9 years) of the Boston University Alzheimer’s Disease Center registry were used in this cross-sectional study. Separate analyses treating SMD as a binary and continuous variable were performed. Subfield volumes were generated using FreeSurfer v6.0, and rsFC strength between the head and body of the hippocampus and the rest of the brain was calculated. Decreased left whole hippocampal volume and weaker rsFC strength between the right body of the hippocampus and the default mode network (DMN) were found in SMD+. Cognitive Change Index score was not correlated with volumetric measures but was inversely correlated with rsFC strength between the right body of the hippocampus and 6 brain networks, including the DMN, task control, and attentional networks. These findings suggest that hippocampal rsFC patterns reflect the current state of SMD in cognitively normal adults and may reflect subtle memory changes that standard neuropsychological tests are unable to capture.

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