The Use of Modified Checklist for Autism in Toddlers (Malay Version) in Differentiating Between Autism Spectrum Disorders and Other Developmental Behavioural Disorders

Objective: The present study examined the sensitivity and specificity of M-CHAT-Malay version [M-CHAT(MV)] to discriminate ASD from other developmental-behavioural disorders. Methods: This study was carried out in the Child Development Centre at a tertiary referral centre. Parents of 130 children aged 18–60 months, referred for developmental-behavioural disorders were asked to complete M-CHAT(MV). A child was considered to have ASD if they failed any 3 of the 23 total items or 2 or more of the 6 critical items. Results: Looking at the total items, M-CHAT(MV) has a good sensitivity (88.9%) to differentiate between ASD and other developmental-behavioural disorders, although specificity was only 47.8%. However, the critical items only has sensitivity of 71.4% and specificity of 77.6%. Sensitivity for children aged 49–60 months old was lower (80.0%) compared to those in the younger age group (100.0% and 90.3% for those aged 25-36 months and 37–48 months respectively). Based on the ROC curve, the optimal criteria to detect ASD was failing 1 out of 6 critical items or 3 out of 23 total items. Conclusion: M-CHAT(MV) is a good screening tool in differentiating ASD from other developmental-behavioural disorders although the critical items’ criteria may need to be lowered to improve its sensitivity in selected cohorts.

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Ocular Cysticercosis — A Profile

Tropical Doctor ◽

10.1177/004947550303300327 ◽

2003 ◽

Vol 33 (3) ◽

pp. 185-188 ◽

Cited By ~ 9

Author(s):

Anuradha Chowdhary ◽

Rajlakshmi Bansal ◽

Kirti Singh ◽

Varinder Singh

Keyword(s):

Retrospective Study ◽

Medical Treatment ◽

Surgical Excision ◽

North India ◽

Age Group ◽

Common Site ◽

Referral Centre ◽

Tertiary Referral ◽

Tertiary Referral Centre ◽

Ocular Cysticercosis

A retrospective study was conducted on all histopathologically proven cases of ocular cysticercosis spanning a decade in a tertiary referral centre of North India. The symptomatology, presentation, complications and treatment therapies of 18 of these patients are discussed. The most common age group to be affected was 11–20 years (50%), while the most common site involved was subconjunctival (78%), followed by lid (11%). Spontaneous extrusion was documented in three cases. Medical treatment with albendazole under the cover of corticosteroids was found to be a useful adjunct to surgical excision.

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HIRSCHSPRUNG’S DISEASE: OUR INSTITUTIONAL EXPERIENCE

10.36106/ijar/7907605 ◽

2021 ◽

pp. 68-71

Author(s):

Arka Chatterjee ◽

Neeraj Tuteja ◽

Ramesh Chand Tanger ◽

Pradeep Gupta ◽

Arvind Kumar Shukla

Keyword(s):

Hirschsprung's Disease ◽

Hirschsprung’S Disease ◽

Tertiary Care ◽

Abdominal Distension ◽

Western India ◽

Age Group ◽

Referral Centre ◽

Tertiary Referral ◽

Tertiary Referral Centre ◽

Multiple Biopsies

BACKGROUND: Hirschsprung's disease is one of the most important causes of functional intestinal obstruction in the paediatric age group. The clinical characteristics of patients with Hirschsprung's disease at a tertiary referral centre were studied over a 22-month period. Aims and Objectives: To study the demography, including Age, Sex, various clinical presentations, types, segment involved, surgery, complications and survival in patients with Hirschsprung's disease at a tertiary care referral centre in Rajasthan, India. Materials and methods: This was a prospective observational study between October 2018 and June 2020, over 22 months, at tertiary referral centre in North-Western India. Clinical data were tabulated, various presentations of the disease were studied, intra-operative ndings were noted and post-operative course was studied. Results: 82 cases of Hirschsprung disease were admitted, of which 66 were male and 16 were female. Of these, 10 presented in the neonatal age group, 25 during infancy (1 month to 1 year of age) and the rest – 47 patients presented beyond infancy. The commonest symptoms in infants and older children was chronic constipation, whereas delayed passage of meconium, abdominal distension and bilious vomiting were among the common symptoms in neonates. The patients underwent exploratory laparotomy with multiple biopsies and diversion colostomies. 43 patients underwent the denitive procedure. In all the 43 patients, Martin's modication of Duhamel's procedure, was the surgery performed. Complications included persistence of constipation, enterocolitis, and a few cases of anastomotic leak.

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A Comprehensive Approach to Thyroid Swellings: Clinical, Sonological, Cytological and Histopathological Correlation

Otorhinolaryngology Clinics - An International Journal ◽

10.5005/aijoc-6-2-28 ◽

2014 ◽

Vol 6 (2) ◽

pp. 28-31

Author(s):

MC Trupthi ◽

S Boobalan

Keyword(s):

Diagnostic Accuracy ◽

Predictive Value ◽

Surgical Intervention ◽

Age Group ◽

Referral Centre ◽

Tertiary Referral ◽

Tertiary Referral Centre ◽

Female Ratio ◽

Histopathological Correlation ◽

Male To Female

ABSTRACT Objectives This study was conducted with the aim of clinicopathological evaluation of thyroid swellings. Setting Tertiary referral centre, Davangere, Karnataka, India. Design Retrospective study. Materials and methods Clinical details, sonological reports, laboratory reports were retrieved from the records for the 110 patients with thyroid swellings who were included in our study, between May 2009 and April 2013 and the data was analyzed. Cytological smears in all patients and histopathology slides in operated patients were retrieved and studied. Results The highest incidence (37.4%) of thyroid swellings were found in age group of 21 to 30 years. The youngest patient being 10 years. Females (90%) predominated in this study, male to female ratio being 1:9. Majority of patients (35%) came with complaints of swelling of duration less than 6 months. Among 110 patients, 36.36% of them were treated conservatively, out of which 7 cases (17.5%) were hyperthyroid, 10 cases (25%) were hypothyroid and 23 cases (57.5%) were euthyroid and the remaining 63.63% of them underwent surgery. Of the 110 patients subjected to FNAC, 16 patients (14.54%) were neoplastic and 94 patients (85.45%) were non-neoplastic. Upon correlation with the histopathology report, the sensitivity of FNAC was 78.57%, specificity was 91.07%, with a positive predictive value of 68.75% and negative predictive value of 94.44%. Diagnostic accuracy of FNAC is 88.50%. Conclusion FNAC and USG are valuable tools in assessing the need for surgical intervention in thyroid swellings. USG guided aspiration will further enhance the cytological yield and diagnostic accuracy.

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