scholarly journals Evaluation of midkine expression in dentigerous cysts, odontogenic keratocysts and different types of ameloblastoma

2013 ◽  
Author(s):  
Naghmeh Jeiroodi ◽  
Mahshid Bagherpour ◽  
Razieh Zare ◽  
Shima Torabi Ardakani ◽  
Azadeh Andisheh Tadbir
Keyword(s):  
Odontogenic Keratocysts ◽  
Dentigerous Cysts ◽  
Different Types

scholarly journals Evaluation of the snowing-like ultrasonographic features of intraosseous jaw pathologies

2020 ◽  
Vol 20 (83) ◽  
pp. 307-310
Author(s):  
Ibrahim Sevki Bayrakdar ◽  
◽  
Ahmet Berhan Yılmaz ◽  
Fatma Akkoca Kaplan ◽  
Elif Bilgir ◽  
...  
Keyword(s):  
Incisive Canal ◽  
Future Studies ◽  
Ultrasonographic Examination ◽  
Odontogenic Keratocysts ◽  
Pathologic Features ◽  
Dentigerous Cysts ◽  
Different Types ◽  
Ultrasonographic Feature

Aim of the study: Ultrasonographic examination of intraosseous jaw pathologies may reveal interesting incidental, mobile hyperechoic particles (“snowflakes”) in anechoic areas. Purpose of this study is to explain and discuss this snowing-like ultrasonographic feature of intraosseous jaw pathologies. Material and methods: This study included 113 patients admitted to our clinic for examination: 43 (38.05%) males and 70 (61.9%) females with a mean age of 34.9 ± 17.2 years (range: 6–72 years). A total of 120 intraosseous lesions were evaluated prior to surgery using ultrasonography; these included non-neoplastic, odontogenic, and non-odontogenic lesions. Results: In total, 5 (4.1%) of the 120 lesions exhibited snowing-like feature on ultrasonography, including 2 (1.6% of total) of 3 incisive canal cysts, 2 (1.6% of total) of 7 dentigerous cysts, and 1 (0.8% of total) of 19 odontogenic keratocysts. Conclusions: Snowflakes evident on ultrasonography of intraosseous jaw lesions may be specific to certain pathologies. Future studies correlating radiologic and pathologic features of intraosseous jaw lesions should focus on ultrasonographic snowing-like appearance in different types of lesions and explore why they occur.

scholarly journals Histopathological subtypes and demographic profile of cystic jaw lesions - A hospital based study

2019 ◽  
Vol 9 (1) ◽  
pp. 1445-1449
Author(s):  
Arnab Ghosh ◽  
Dilashma GhartiMagar ◽  
Sushma Thapa ◽  
Om Prakash Talwar
Keyword(s):  
Odontogenic Cysts ◽  
Cross Sectional ◽  
Female Ratio ◽  
Odontogenic Keratocysts ◽  
Odontogenic Epithelium ◽  
Dentigerous Cysts ◽  
Epithelial Cysts ◽  
Different Types ◽  
Male Female Ratio ◽  
Age Range

Background: Odontogenic cysts are defined as the epithelial cysts which arise from odontogenic epithelium and occur in tooth bearing regions of jaws. The objective of the present study was to analyze different histopathological types of cystic jaw lesions and to determine the distribution of their relative frequency according to site, sex, size and age group. Materials and methods: This study was a cross sectional hospital based observational study conducted in the Department of Pathology, Manipal Teaching Hospital. All cases with cystic jaw lesions on histopathology during the study period from January 2014 to December 2018 were included in the study. Results: Thirty-two cases of cystic jaw lesions were reported during the study period. Females were more commonly affected in our study with a male: female ratio of 1:1.9. The age range in the study was 9 to 71 years with a mean age of 33.3 years. The most frequent type was radicular cysts followed by dentigerous cysts, odontogenic keratocysts and cystic ameloblastoma. Radicular cysts showed the most female predilection with a ratio of 1:4.3. and a mean age of 35.6 years. Majority of dentigerous cysts were seen in patients below 30 years. Both radicular cysts and dentigerous cysts showed more involvement of maxilla but odontogenic keratocysts were more common in mandible Conclusions: The present study corroborate with other similar literature with respect to the frequency percentage of different types of jaw cysts.However, female predilection was seen in radicular and dentigerous cysts. Maxilla was the more common site except in odontogenic keratocysts.

scholarly journals Differential Expression of Claudin in Odontogenic Cysts

2021 ◽  
Author(s):  
Ekarat Phattarataratip ◽  
Kraisorn Sappayatosok
Keyword(s):  
Pairwise Comparison ◽  
Odontogenic Cyst ◽  
Odontogenic Cysts ◽  
Positive Staining ◽  
Pathogenic Role ◽  
Dentigerous Cysts ◽  
Different Types ◽  
Level Of Significance ◽  
Post Hoc ◽  
Spearman’S Correlation

Abstract Objective This study aimed to analyze claudin-1, -4, and -7 expression in different types of odontogenic cysts (odontogenic keratocysts [OKCs], dentigerous cysts [DCs], calcifying odontogenic cysts [COCs], and radicular cysts [RCs]) as well as its association with OKC recurrence. Materials and Methods Seventy samples of odontogenic cysts samples were immunohistochemically stained to detect claudin-1, -4, and -7 expression. Patient information and OKC recurrence data were recorded. The staining was analyzed semiquantitatively and categorized based on the pattern and percentage of positively stained cystic epithelial cells. Statistical Analysis Expression of different claudins between groups was analyzed using the Kruskal–Wallis test with Dunn's test, followed by post hoc pairwise comparison. The association between claudin expression and OKC recurrence was analyzed by the Mann–Whitney U test. Correlations among claudin expression were examined with Spearman's correlation coefficient. Level of significance was at p < 0.005. Results Claudin-1 was widely expressed in every odontogenic cyst. Most DCs (50%) expressed claudin-1 in more than 75% of cells, as did RCs (65%), while most OKCs (50%) expressed claudin-1 in 26 to 50% of cells. Most COCs (50%) expressed claudin-1 in 51 to 75% of cells. Every sample of OKC and RC was positive for claudin-4, but no sample showed staining in more than 51% of cells. Every odontogenic cyst was positive for claudin-7. DCs (35%), OKCs (55%), and RCs (40%) mostly showed staining in 26 to 50% of cells. High claudin-1 expression was shown in COCs, DCs, and RCs, while low expression of claudin-4 was shown in every odontogenic cyst. For claudin-7, the expression is high only in COCs. Claudin-1 and -4 was significantly different among each odontogenic cyst. High expression of claudin-1 was correlated with OKC recurrence. The correlations of claudin-1 with claudin-7 expression and claudin-4 with claudin-7 expression were significant in DCs. In COCs, claudin-1 and claudin-7 expression was significantly correlated. Conclusions The expression of claudin-1, -4, and -7 was present in every odontogenic cyst, but the proportion of positive staining cells was different. Expression of claudin-1 is associated with OKC recurrence. Dysregulation of claudin expression may play a pathogenic role in cyst pathogenesis.

A radiologic analysis of dentigerous cysts and odontogenic keratocysts associated with a mandibular third molar

2001 ◽  
Vol 91 (6) ◽  
pp. 743-747 ◽  
Author(s):  
Goichi Tsukamoto ◽  
Akira Sasaki ◽  
Takehisa Akiyama ◽  
Tohru Ishikawa ◽  
Koji Kishimoto ◽  
...  
Keyword(s):  
Third Molar ◽  
Odontogenic Keratocysts ◽  
Mandibular Third Molar ◽  
Dentigerous Cysts

Immunolocalization of PTCH Protein in Odontogenic Cysts and Tumors

2002 ◽  
Vol 81 (11) ◽  
pp. 757-760 ◽  
Author(s):  
D.C. Barreto ◽  
A.E. Bale ◽  
L. De Marco ◽  
R.S. Gomez
Keyword(s):  
Basal Cell ◽  
Tumor Suppression ◽  
Protein Product ◽  
Odontogenic Tumors ◽  
Odontogenic Cysts ◽  
Odontogenic Keratocysts ◽  
Basal Cell Carcinomas ◽  
Different Types ◽  
Embryologic Development

The human patched gene ( PTCH) functions in both embryologic development and tumor suppression. PTCH mutations have been found in odontogenic keratocysts. However, the expression and localization of the protein product of the gene have not been determined in odontogenic tumors and cysts. We investigated 68 odontogenic lesions by immunohistochemistry, and compared their PTCH expression with that in basal cell carcinomas. All odontogenic lesions, including two keratocysts with truncating mutations, were positive for PTCH. Different types of lesions had different amounts of staining. Lack of staining was noted in the majority of basal cell carcinomas. Taken together, these data suggest that odontogenic keratocysts arise with heterozygous mutations of the PTCH gene.

scholarly journals Frequency of Different Odontogenic Cysts in Patients Visiting Oral Maxillofacial Department of Dental Hospitals in Peshawar

2015 ◽  
Vol 1 (2) ◽  
pp. 29-35
Author(s):  
Sofia Haider Durrani ◽  
Waqar -Ul- Nisa ◽  
Saira Afridi
Keyword(s):  
Relative Frequency ◽  
Odontogenic Cysts ◽  
Anterior Maxilla ◽  
Odontogenic Keratocysts ◽  
Posterior Maxilla ◽  
Dentigerous Cysts ◽  
History Of

Background and Objective:The aim of this study was to investigate the relative frequency of odontogenic cysts in two local dental college hospitals.Methodology:In this study 90 cysts from both jaws, treated at Khyber College of Dentistry and Sardar Begum Dental College from March 2008 to March 2013 were analyzed in order to evaluate the incidence of these cysts.Results:Case history of 52 males and 38 females were analyzed. The age of patients varied from 07 to 70 years, with a mean age of 26.4±13.89. In this 5-year study of odontogenic cysts, 48 were radicular cysts, 22 were odontogenic keratocysts and 20 were dentigerous cysts. Out of these 46 cysts were present in the maxilla and 44 in the mandible. In the maxilla 46.7%were present in the anterior maxilla and 4.4% in the posterior maxilla. In the mandible 35.6% were present in the posterior mandible and 13.3% in the anterior mandible.Conclusion:From the findings of this study we conclude that odontogenic cysts were mostly inflammatory in nature i.e. the radicular cysts and was followed by odontogenic keratocysts. Majority of the cysts were located in the anterior maxilla and posterior mandible regions. The male predilection was higher as compared to females.

scholarly journals Deep Learning-Based Microscopic Diagnosis of Odontogenic Keratocysts and Non-Keratocysts in Haematoxylin and Eosin-Stained Incisional Biopsies

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2184
Author(s):  
Roopa S. Rao ◽  
Divya B. Shivanna ◽  
Kirti S. Mahadevpur ◽  
Sinchana G. Shivaramegowda ◽  
Spoorthi Prakash ◽  
...  
Keyword(s):  
Deep Learning ◽  
Image Classification ◽  
Data Augmentation ◽  
Image Acquisition ◽  
Region Of Interest ◽  
Automation System ◽  
Odontogenic Keratocysts ◽  
Jaw Cyst ◽  
Dentigerous Cysts ◽  
Stromal Component

Background: The goal of the study was to create a histopathology image classification automation system that could identify odontogenic keratocysts in hematoxylin and eosin-stained jaw cyst sections. Methods: From 54 odontogenic keratocysts, 23 dentigerous cysts, and 20 radicular cysts, about 2657 microscopic pictures with 400× magnification were obtained. The images were annotated by a pathologist and categorized into epithelium, cystic lumen, and stroma of keratocysts and non-keratocysts. Preprocessing was performed in two steps; the first is data augmentation, as the Deep Learning techniques (DLT) improve their performance with increased data size. Secondly, the epithelial region was selected as the region of interest. Results: Four experiments were conducted using the DLT. In the first, a pre-trained VGG16 was employed to classify after-image augmentation. In the second, DenseNet-169 was implemented for image classification on the augmented images. In the third, DenseNet-169 was trained on the two-step preprocessed images. In the last experiment, two and three results were averaged to obtain an accuracy of 93% on OKC and non-OKC images. Conclusions: The proposed algorithm may fit into the automation system of OKC and non-OKC diagnosis. Utmost care was taken in the manual process of image acquisition (minimum 28–30 images/slide at 40× magnification covering the entire stretch of epithelium and stromal component). Further, there is scope to improve the accuracy rate and make it human bias free by using a whole slide imaging scanner for image acquisition from slides.

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