scholarly journals Parkinson’s disease – a review of pathogenesis, recent advances in management, and challenges of care in sub-Saharan Africa

2021 ◽  
pp. e35
Author(s):  
Akintomiwa I. Makanjuola ◽  
Funmilola T. Taiwo ◽  
Joseph O. Yaria ◽  
Rufus O. Akinyemi ◽  
Adesola Ogunniyi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Treatment Options ◽  
Sub Saharan Africa ◽  
Treatment Modalities ◽  
Unequal Distribution ◽  
Low Resource Settings ◽  
Low Resource ◽  
Recent Advances ◽  
Sub Saharan

Parkinson’s disease (PD) remains a common neurodegenerative movement disorder with significant morbidity, which is expected to increase worldwide in the coming decades. Since its initial description, much has been elucidated about its etiology, pathogenesis, and the role of genetic and environmental risk factors. Effective treatments, including surgical therapies, have been discovered. Despite these strides, many questions remain unanswered; PD remains an active research area with ongoing efforts to discover newer treatment modalities and identify neuroprotective strategies. As with many neurological conditions, there is an unequal distribution of health resources, resulting in some management challenges in low resource settings, especially sub-Saharan Africa (SSA). In this communication, we provide an overview of PD etiopathogenesis, including genetics and management strategies, including some recent advances with respect to treatment options and disease modification approaches. Finally, we discuss some challenges of PD management in low-resource settings and highlight efforts to turn the tide.

Could Mucuna pruriens be the answer to Parkinson's disease management in sub-Saharan Africa and other low-income countries worldwide?

2020 ◽  
Vol 73 ◽  
pp. 3-7 ◽  
Author(s):  
Natasha Fothergill-Misbah ◽  
Harshvadan Maroo ◽  
Momodou Cham ◽  
Gianni Pezzoli ◽  
Richard Walker ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Management ◽  
Low Income ◽  
Sub Saharan Africa ◽  
Low Income Countries ◽  
Mucuna Pruriens ◽  
Sub Saharan

The management of Parkinson's disease in sub-Saharan Africa

2012 ◽  
Vol 12 (6) ◽  
pp. 661-666 ◽  
Author(s):  
Catherine Dotchin ◽  
Richard Walker
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sub Saharan Africa ◽  
Sub Saharan

scholarly journals Parkinson’s Disease in Sub-Saharan Africa: A Review of Epidemiology, Genetics and Access to Care

2018 ◽  
Vol 11 (2) ◽  
pp. 53-64 ◽  
Author(s):  
Uduak Williams ◽  
Oliver Bandmann ◽  
Richard Walker
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Access To Care ◽  
Sub Saharan Africa ◽  
Sub Saharan

scholarly journals The modern pre-levodopa era of Parkinson's disease: insights into motor complications from sub-Saharan Africa

Brain ◽  
2014 ◽  
Vol 137 (10) ◽  
pp. 2731-2742 ◽  
Author(s):  
R. Cilia ◽  
A. Akpalu ◽  
F. S. Sarfo ◽  
M. Cham ◽  
M. Amboni ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sub Saharan Africa ◽  
Motor Complications ◽  
Sub Saharan

scholarly journals Detection and Management of Diabetes during Pregnancy in Low Resource Settings: Insights into Past and Present Clinical Practices

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Bettina Utz ◽  
Alexandre Delamou ◽  
Loubna Belaid ◽  
Vincent De Brouwere
Keyword(s):  
Gestational Diabetes ◽  
Tertiary Care ◽  
Sub Saharan Africa ◽  
Publication Date ◽  
Clinical Practices ◽  
Middle Income ◽  
Adequate Treatment ◽  
Low Resource Settings ◽  
Low Resource ◽  
Sub Saharan

Background.Timely and adequate treatment is important to limit complications of diabetes affecting pregnancy, but there is a lack of knowledge on how these women are managed in low resource settings.Objective. To identify modalities of gestational diabetes detection and management in low and lower middle income countries.Methods. We conducted a scoping review of published literature and searched the databases PubMed, Web of Science, Embase, and African Index Medicus. We included all articles published until April 24, 2016, containing information on clinical practices of detection and management of gestational diabetes irrespective of publication date or language.Results. We identified 23 articles mainly from Asia and sub-Saharan Africa. The majority of studies were conducted in large tertiary care centers and hospital admission was reported in a third of publications. Ambulatory follow-up was generally done by weekly to fortnightly visits, whereas self-monitoring of blood glucose was not the norm. The cesarean section rate for pregnancies affected by diabetes ranged between 20% and 89%. Referral of newborns to special care units was common.Conclusion. The variety of reported provider practices underlines the importance of promoting latest consensus guidelines on GDM screening and management and the dissemination of information regarding their implementation.

scholarly journals Engaging Patients for Clinical Trials in Africa: Patient-Centered Approaches

2020 ◽  
pp. 942-947
Author(s):  
Miriam Mutebi ◽  
Dicey Scroggins ◽  
Virgil Simons ◽  
Naomi Ohene Oti ◽  
Nazik Hammad
Keyword(s):  
Clinical Trials ◽  
Sub Saharan Africa ◽  
Patient Centered ◽  
Low Resource Settings ◽  
Low Resource ◽  
History Of ◽  
Different Populations ◽  
Sub Saharan ◽  
Best Fit ◽  
Improve Patient

Clinical trials in oncology are an emergent field in sub-Saharan Africa. There is a long history of clinical trials in high-income countries (HICs), with increasing attempts to develop patient-centric approaches and to evaluate patient-centered outcomes. The challenge remains as to how these trends could be adopted in low-resource settings and adapted to best fit the different health ecosystems that coexist on the African continent. Models that evaluate patient-related outcomes and measures and that are used in HICs must be modified, adopted, and adapted to suit the diverse populations and the low-resource settings in most of the continent. Patient engagement in clinical trials in Africa must be well nuanced, and it demands innovation and application of models that consider established but tailored notions/principles of patient and community engagement and the unique sociocultural aspects of different populations. It also must be linked to strategies that aim to improve patient education, health literacy, and access to services and to encourage and protect patient autonomy.

Parkinson’s disease in sub-Saharan Africa: step-by-step into the challenge

2011 ◽  
Vol 1 (3) ◽  
pp. 193-202 ◽  
Author(s):  
Roberto Cilia ◽  
Albert Akpalu ◽  
Momodou Cham ◽  
Alba Bonetti ◽  
Marianna Amboni ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sub Saharan Africa ◽  
Sub Saharan

scholarly journals E-Learning for Medical Education in Sub-Saharan Africa and Low-Resource Settings: Viewpoint

10.2196/12449 ◽  
2019 ◽  
Vol 21 (1) ◽  
pp. e12449 ◽  
Author(s):  
Sandra Barteit ◽  
Albrecht Jahn ◽  
Sekelani S Banda ◽  
Till Bärnighausen ◽  
Annel Bowa ◽  
...  
Keyword(s):  
Medical Education ◽  
Sub Saharan Africa ◽  
Low Resource Settings ◽  
Low Resource ◽  
E Learning ◽  
Sub Saharan

scholarly journals Parents’ perceptions of core outcomes in neonatal research in two Nigerian neonatal units

2020 ◽  
Vol 4 (1) ◽  
pp. e000669
Author(s):  
Sarah Kathryn Read ◽  
Aisha Jibril ◽  
Olukemi Tongo ◽  
Abimbole Akindolire ◽  
Isa Abdulkadir ◽  
...  
Keyword(s):  
Core Outcome Set ◽  
Good Health ◽  
Sub Saharan Africa ◽  
Low Resource Settings ◽  
Low Resource ◽  
Outcome Set ◽  
Southwest Nigeria ◽  
Sub Saharan ◽  
Health Complications ◽  
Neonatal Problems

BackgroundThere is a scarcity of information regarding the most important outcomes for research in neonatal units in low-resource settings. Identification of important outcomes by different stakeholder groups would inform the development of a core outcome set (COS) for use in neonatal research.ObjectiveTo determine the perceptions and opinions of parents of newborn babies regarding what outcomes were most important to them in order to contribute towards development of a COS for neonatal research in sub-Saharan Africa.MethodsSemistructured interviews were undertaken with parents, mostly mothers, of babies admitted to one neonatal unit in North central and one in Southwest Nigeria. Participants were purposively sampled to include parents of babies with common neonatal problems such as prematurity.ResultsWe conducted 31 interviews. The most frequently raised outcomes were breast feeding, good health outcomes for their baby, education, growth and financial cost. Parents placed more emphasis on quality of life and functional status than health complications.ConclusionsThe opinions of parents need to be considered in developing a COS for neonatal research in low-resource settings. Further research should assess the opinions of families in other low-resource settings and also engage a broader range of stakeholders.

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