Diagnostic value of heart-type fatty acid binding protein determined by the rapid qualitative chromatographic immunoassay method for the detection of minor myocardial damage in patients presenting with non-ST elevation acute coronary syndrome

Heart-Fatty Acid-Binding Protein (H-FABP) is a membrane-bound protein that facilitates transport of fatty acids from the blood intothe heart. It is a low molecular weight cytoplasmic protein. Because of its small size and location, it is released rapidly into the bloodfollowing myocardial damage. The H-FABP levels rise as early as between 1−3 hours after the onset of Acute Coronary Syndrome, thepeak situation between 6−-8 hours, and returns to normal within 24 hours. The purpose of this study was to know the cut-off value ofHeart Fatty Acid Binding Protein with a sensitivity of at least 90% in patients with acute coronary syndrome in the Dr. Sardjito HospitalYogyakarta. The researchers undertook a cross sectional evaluation of 75 consecutive patients admitted with acute chest pain suggestiveof acute coronary syndrome (ACS). The H-FABP was measured by using immunoturbidimetry assay methods. The receiver operatingcharacteristic (ROC) analysis was calculated for the cut off point, sensitivity and specificity estimation. A total of 75 patients (59 in theACS group and 16 in the control group) were included in this study, and the majority of the ACS group (64 [76.2%]) were male patientswith AMI, 20 (26.7%) had an ST-elevation myocardial infarction and the rest (21 [28%]) had a non–ST-elevation myocardial infarction.The optimized cut-off obtained for h-FABP was 15 ng/mL, showing a sensitivity and specificity of the H-FABP assay for detecting ACSas 98.31 (95% CI 90 to 100) and 93.75% (95% CI 86 to 99), respectively. The areas under the receiver operator characteristic (ROC)curves to distinguish ACS from non-ACS were 0.983 (95% CI: 0.927– 0.999) for H-FABP. The optimized cut-off obtained for H-FABPwas 15 ng/mL, showing a 98.31% sensitivity and 93.75% specificity for detecting ACS in the Dr. Sardjito Hospital Yogyakarta.

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Heart-Type Fatty Acid-Binding Protein Predicts Long-Term Mortality and Re-Infarction in Consecutive Patients With Suspected Acute Coronary Syndrome Who Are Troponin-Negative

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2009.12.062 ◽

2010 ◽

Vol 55 (23) ◽

pp. 2590-2598 ◽

Cited By ~ 101

Author(s):

Karthik Viswanathan ◽

Niamh Kilcullen ◽

Christine Morrell ◽

Sue J. Thistlethwaite ◽

Mohan U. Sivananthan ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Fatty Acid ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Fatty Acid Binding ◽

Coronary Syndrome ◽

Acid Binding Protein ◽

Long Term Mortality

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Prognostic Value of a Qualitative Test for Heart-Type Fatty Acid-Binding Protein in Patients With Acute Coronary Syndrome

International Heart Journal ◽

10.1536/ihj.46.601 ◽

2005 ◽

Vol 46 (4) ◽

pp. 601-606 ◽

Cited By ~ 13

Author(s):

Masaru Suzuki ◽

Shingo Hori ◽

Shigetaka Noma ◽

Kenji Kobayashi

Keyword(s):

Acute Coronary Syndrome ◽

Fatty Acid ◽

Prognostic Value ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Fatty Acid Binding ◽

Coronary Syndrome ◽

Acid Binding Protein ◽

Qualitative Test

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Elevated Heart-Type Fatty Acid-Binding Protein Predicts Early Myocardial Injury and Aids in the Diagnosis of Non-St Elevation Myocardial Infarction

Hong Kong Journal of Emergency Medicine ◽

10.1177/102490790901600303 ◽

2009 ◽

Vol 16 (3) ◽

pp. 141-147 ◽

Cited By ~ 5

Author(s):

GY Naroo ◽

S Mohamed Ali ◽

V Butros ◽

A Al Haj ◽

I Mohammed ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Coronary Syndrome ◽

Fatty Acid ◽

Chest Pain ◽

Fatty Acid Binding Protein ◽

Troponin T ◽

Binding Protein ◽

Fatty Acid Binding ◽

Coronary Syndrome ◽

Acid Binding Protein

Background Biomarkers play an important role in the early diagnosis, risk stratification and management of patients with the acute coronary syndrome. Objective The objective of this study was to evaluate the clinical reliability of heart-type fatty acid-binding protein (h-FABP) in identifying patients with the acute coronary syndrome in the early hours of chest pain. Methods Creatine kinase (CK-MB) (in laboratory), troponin T (in laboratory) and h-FABP (with point-of-care test CardioDetect®) were performed on 791 patients who presented with chest pain with duration since onset ranging from 20 minutes to 12 hours. Results Data of the 791 patients were analysed. h-FABP had a higher sensitivity of 75.76% and a specificity of 96.97% compared with 58.59% and 98.84% for troponin T and 68.69% and 97.54% for CK-MB respectively (in the first 6 hours). Conclusion: h-FABP was found to be a better biomarker of cardiac necrosis in the early hours in the diagnosis of non-conclusive ECG in patients with acute myocardial infarction. (Hong Kong j.emerg.med. 2009;16:141–147)

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