scholarly journals Elevated Heart-Type Fatty Acid-Binding Protein Predicts Early Myocardial Injury and Aids in the Diagnosis of Non-St Elevation Myocardial Infarction

2009 ◽  
Vol 16 (3) ◽  
pp. 141-147 ◽  
Author(s):  
GY Naroo ◽  
S Mohamed Ali ◽  
V Butros ◽  
A Al Haj ◽  
I Mohammed ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Coronary Syndrome ◽  
Fatty Acid ◽  
Chest Pain ◽  
Fatty Acid Binding Protein ◽  
Troponin T ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Coronary Syndrome ◽  
Acid Binding Protein

Background Biomarkers play an important role in the early diagnosis, risk stratification and management of patients with the acute coronary syndrome. Objective The objective of this study was to evaluate the clinical reliability of heart-type fatty acid-binding protein (h-FABP) in identifying patients with the acute coronary syndrome in the early hours of chest pain. Methods Creatine kinase (CK-MB) (in laboratory), troponin T (in laboratory) and h-FABP (with point-of-care test CardioDetect®) were performed on 791 patients who presented with chest pain with duration since onset ranging from 20 minutes to 12 hours. Results Data of the 791 patients were analysed. h-FABP had a higher sensitivity of 75.76% and a specificity of 96.97% compared with 58.59% and 98.84% for troponin T and 68.69% and 97.54% for CK-MB respectively (in the first 6 hours). Conclusion: h-FABP was found to be a better biomarker of cardiac necrosis in the early hours in the diagnosis of non-conclusive ECG in patients with acute myocardial infarction. (Hong Kong j.emerg.med. 2009;16:141–147)

Clinical assessment of heart-type fatty acid binding protein in early diagnosis of acute coronary syndrome

2008 ◽  
Vol 15 (3) ◽  
pp. 140-144 ◽  
Author(s):  
Hector Alonso Valle ◽  
Luis García-Castrillo Riesgo ◽  
Miguel Sántalo Bel ◽  
Francisco Epelde Gonzalo ◽  
Miguel Sánchez Sanchez ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Fatty Acid ◽  
Early Diagnosis ◽  
Clinical Assessment ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Coronary Syndrome ◽  
Acid Binding Protein

scholarly journals Heart Fatty Acid Binding Protein for the Diagnosis of Myocardial Ischemia and Infarction

2016 ◽  
Vol 1 (6) ◽  
pp. 702-710
Author(s):  
Paul O Collinson ◽  
Jennifer Hersey ◽  
Rosalind Bray ◽  
David Gaze ◽  
Pitt Lim ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Fatty Acid ◽  
Chest Pain ◽  
Myocardial Ischemia ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Analytical Performance ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Clinical Diagnostic

Abstract Objective To establish the analytical performance of a heart fatty acid binding protein (HFABP) method suitable for routine clinical use and examine its role for the diagnosis of myocardial ischemia and myocardial infarction. Methods Analyses of HFABP were performed on an Advia 2400 (Siemens Healthcare Diagnostics). Imprecision, limit of detection (LOD), limit of blank (LOB), and linearity were assessed using standard methods. Stability was assessed at 4 °C, −20 °C, and with 3 repeated freeze-thaw cycles. Clinical diagnostic performance was assessed using chest pain in patients, with a final diagnosis according to the universal definition of myocardial infarction with cardiac troponin I (cTnI) measured on the Siemens Advia Centaur (cTnI Ultra method, 99th percentile 50 ng/L, 10% CV 30 ng/L). Ischemia was detected using sampling pre- and postangioplasty. Results LOD and analytical imprecision exceeded the manufacturer's specification (LOD 1.128 μg/L, 20% CV 1.3 μg/L, 10% CV 2.75 μg/L). Clinical diagnostic efficiency was less than cTnI. Addition of HFABP to cTnI produced a modest increase in diagnostic sensitivity at a cost of significant loss of specificity. Conclusions Although the test had excellent analytical performance, it did not contribute to the clinical diagnosis of patients with chest pain. HFABP appears to be a marker of myocardial infarction not myocardial ischemia.

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