The Impact of Diagnostic Status on Quality of Life in Irritable Bowel Syndrome

The aims of this exploratory study were to examine whether tryptophan hydroxylase ( TPH) gene polymorphisms are associated with psychosocial factors in women with irritable bowel syndrome (IBS). TPH is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms, TPH1 and TPH2. Four single nucleotide polymorphisms (SNPs) in the TPH1 gene and one SNP in the TPH2 gene were selected based on previous studies investigating associations between these SNPs and psychiatric or behavioral disorders. One hundred ninety-nine Caucasian women with IBS were included. Results of univariate analysis showed no association between TPH1and TPH2 gene SNPs and current level of psychological distress or psychiatric illness. However, TPH1 gene SNPs were associated with IBS-related cognitions (rs4537731 and rs21105) and quality of life (rs684302 and rs1800532), in particular the mental health and energy subscales. These associations were independent of the subjects’ levels of gastrointestinal symptoms. These results suggest that patients’ perception of their illness, and of the impact it has on their lives, may be subject to genetic influences, in this case sequence variants in TPH1. However, caution should be used in interpreting these results given the large number of hypothesis tests performed in this exploratory hypothesis-generating study, and the results should be considered tentative until confirmed in an independent sample.

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Su2085 The Impact of Fear of GI Symptoms on Quality of Life Impairment Due to Irritable Bowel Syndrome

Gastroenterology ◽

10.1016/s0016-5085(14)61963-6 ◽

2014 ◽

Vol 146 (5) ◽

pp. S-542

Author(s):

Jeffrey M. Lackner ◽

Gregory D. Gudleski ◽

Changxing Ma ◽

Akriti Dewanwala ◽

Bruce D. Naliboff

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Gi Symptoms ◽

Irritable Bowel ◽

The Impact

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Coping Strategies and Irrational Beliefs as Mediators of the Health-Related Quality of Life Impairments in Irritable Bowel Syndrome

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.242.strt ◽

2015 ◽

Vol 24 (2) ◽

pp. 159-164 ◽

Cited By ~ 14

Author(s):

Mihaela Fadgyas Stanculete ◽

Silviu Matu ◽

Cristina Pojoga ◽

Dan L. Dumitrascu

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Irrational Beliefs ◽

Coping Mechanisms ◽

Dysfunctional Attitudes ◽

Brief Cope ◽

Health Related ◽

Irritable Bowel ◽

The Impact

Background & Aims: Irritable bowel syndrome (IBS) is a chronic and disabling gastrointestinal disorder. Although considerable research has underlined the influence of coping mechanisms as the determinants of the quality of life (QOL), only limited data are available regarding the specific coping mechanisms used by IBS patients to manage illness in daily life. Irrational cognitions are known to emerge in stressful situations such as chronic diseases, and it has been proposed to have implications in the QOL. The aim of this study was to explore the relationship between coping styles and irrational beliefs in predicting the effects of IBS symptoms on the health-related QOL (HRQOL).Methods: A cross-sectional study was performed at two tertiary gastroenterology centers. A sample of 70 consecutive IBS patients and 55 healthy controls was studied. All participants completed the Brief Cope Inventory, the Dysfunctional Attitudes Scale, the Short-Form Health Survey and a demographic questionnaire.Results: All the HRQOL scores of the group with IBS were significantly lower than the HRQOL scores of the healthy group [Pillai's trace V = 0.404, F(8, 116) = 9.833, p < 0.001]. Irritable bowel syndrome patients used more problem-focused coping and avoidant-oriented coping than healthy subjects. The impact of IBS symptoms on HRQOL distress is mediated by irrational beliefs and avoidant oriented coping.Conclusions: Our findings highlight the role of irrational cognition and coping mechanisms in patients with IBS. The results underline the importance of the evaluation of psychological aspects of IBS with the possibility of having more tailored treatments for these patients.

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The Impact of Mood and Somatization on Quality-of-life in Irritable Bowel Syndrome (IBS)

The American Journal of Gastroenterology ◽

10.14309/00000434-201010001-01328 ◽

2010 ◽

Vol 105 ◽

pp. S490-S491

Author(s):

Gregory Sayuk ◽

Vladimir Kushnir ◽

Amir Sabzpoushan ◽

Prisca Kibe ◽

Patrick Lustman ◽

...

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Irritable Bowel ◽

The Impact

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Racial Differences in the Impact of Irritable Bowel Syndrome on Health-Related Quality of Life

Journal of Clinical Gastroenterology ◽

10.1097/01.mcg.0000140190.65405.fb ◽

2004 ◽

Vol 38 (9) ◽

pp. 782-789 ◽

Cited By ~ 27

Author(s):

Ian M Gralnek ◽

Ron D Hays ◽

Amy M Kilbourne ◽

Lin Chang ◽

Emeran A Mayer

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Racial Differences ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Irritable Bowel ◽

The Impact

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Evaluation of the Impact of Self-Efficacy-Based Training on Depression, Self-Care Behaviors, and Quality of Life in Patients with Irritable Bowel Syndrome

10.32592/ajnpp.2021.8.2.105 ◽

2020 ◽

pp. 90-95

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Self Efficacy ◽

Self Care ◽

Control Group ◽

Life Questionnaire ◽

Irritable Bowel ◽

The Impact

Background and Objectives: Irritable bowel syndrome is the most common diagnosis among patients with gastrointestinal diseases and can adversely affect their quality of life. In this regard, the present study aimed to evaluate the effectiveness of self-efficacy-based training on depression, self-care behaviors, and the quality of life of patients with irritable bowel syndrome. Materials and Methods: This applied quasi-intervention study was conducted based on a pretest-posttest design with a control group and follow-up. The statistical population included all patients with irritable bowel syndrome who referred to Khorshid Hospital in Isfahan, Iran from September to November 2019. The samples were selected using the convenience sampling method. In total, 30 patients with irritable bowel syndrome were included in the study and randomly divided into two groups of intervention and control. The data were collected using Beck depression inventory, self-care questionnaire, and quality of life questionnaire. The intervention group received four sessions of self-efficacy training (one session per week for 90 min), while the control group did not receive any training. Two months later, the follow-up period was completed. The collected data were analyzed using repeated measures of analysis of variance in SPSS software (version 22). Results: The results showed that self-efficacy training was effective in decreasing depression (P<0.0001, F=35.39) and increasing quality of life (P<0.0001, F=120.30) and self-care behaviors (P<0.0001, F=70.50) in patients with irritable bowel syndrome. Conclusion: It can be concluded that training based on self-efficacy theory can effectively reduce depression and increase self-care behaviors and quality of life in patients with irritable bowel syndrome.

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High prevalence of irritable bowel syndrome-type symptoms in microscopic colitis: implications for treatment

Therapeutic Advances in Gastroenterology ◽

10.1177/1756284818783600 ◽

2018 ◽

Vol 11 ◽

pp. 175628481878360 ◽

Cited By ~ 4

Author(s):

John S. Kane ◽

Andrew J. Irvine ◽

Yannick Derwa ◽

Olorunda Rotimi ◽

Alexander C. Ford

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Psychological Health ◽

Short Form ◽

Demographic Data ◽

Depression Scale ◽

Microscopic Colitis ◽

Irritable Bowel ◽

The Impact

Background: Patients with microscopic colitis (MC) often present with abdominal pain and diarrhoea, and previous data suggest that there may be overlap between MC and irritable bowel syndrome (IBS). We evaluated the prevalence of IBS-type symptoms in patients with MC, and assess the impact of these symptoms on psychological health and quality of life. Methods: We conducted a cross-sectional survey of individuals with a histological diagnosis of MC, collecting demographic data, Rome III IBS-type symptoms, and mood, somatization, and quality of life data. Results: In total, 151 (31.6%) of 478 individuals with a new diagnosis of MC completed questionnaires, 52 (34.4%) of whom reported IBS-type symptoms. The commonest histological subtype was collagenous colitis (51.7%, n = 78), followed by lymphocytic colitis (39.1%, n = 59). Individuals with IBS-type symptoms had significantly higher levels of anxiety [Hospital Anxiety and Depression Scale (HADS) anxiety score 8.6 versus 5.1, p < 0.001], depression (HADS depression score 6.2 versus 3.6, p = 0.001), and somatoform-type behaviour (Patient Health Questionnaire 15 score 12.7 versus 8.0, p < 0.001) compared with individuals who did not. Those with IBS-type symptoms scored significantly worse across all domains of the 36-item Short Form questionnaire, except for physical functioning. Conclusions: More than one third of individuals with MC reported IBS-type symptoms, although whether this is due to ongoing inflammation is unclear. These individuals had higher levels of anxiety, depression, and somatization, and impaired quality of life. Identifying concomitant IBS in individuals with MC may have important implications for management decisions.

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