scholarly journals Aspects of classification and diagnostic search for transient and persistent facial erythema

2021 ◽  
Author(s):  
T.А. Сысоева ◽  
И.Е. Фролова ◽  
Е.К. Мураховская ◽  
А.С. Бишарова ◽  
И.Б. Мерцалова
Keyword(s):  
Lupus Erythematosus ◽  
Carcinoid Syndrome ◽  
Accurate Diagnosis ◽  
Laboratory Studies ◽  
Facial Flushing ◽  
Systemic Lupus ◽  
Benign Diseases ◽  
Facial Erythema ◽  
Family Practitioners ◽  
The Face

Розацеа – одно из наиболее частых заболеваний кожи лица. Клиническая картина розацеа характеризуется покраснением центральных частей лица, приливами, телеангиэктазиями, реже папулами и пустулами, фиматозными проявлениями. С покраснением кожи лица сталкиваются дерматологи, аллергологи, терапевты, семейные врачи. В типичных случаях диагностика розацеа не вызывает затруднений, однако покраснением кожи лица и приливами может сопровождаться множество заболеваний, как доброкачественных, так и злокачественных. Большинство случаев вызваны очень распространенными доброкачественными заболеваниями, такими как розацеа, которые легко диагностируются после тщательного сбора анамнеза и осмотра. Однако в некоторых случаях точный диагноз требует дальнейших лабораторных, радиологических или гистопатологических исследований. Например, карциноидный синдром, феохромоцитому, системный мастоцитоз, дерматомиозит, системную красную волчанку, анафилаксию необходимо исключить лабораторными исследованиями. В статье приведены основные заболевания, которые необходимо учитывать при диагностике транзиторной или постоянной эритемы при розацеа. Rosacea is one of the most common conditions on the face. Rosacea affecting the central parts of the face and is characterized by erythema, flushing, telangiectasia; papules and pustules. Cutaneous flushing – a common presenting complaint to dermatologists, allergists, internists, and family practitioners. Diagnosis typical cases of rosacea is not difficult, but many diseases, both benign and malignant, can be associated with facial flushing and erythema. Most cases are caused by very common, benign diseases, such as rosacea, that are readily apparent after a thorough taking of history and physical examination. However, in some cases, accurate diagnosis requires further laboratory, radiologic, or histopathologic studies. In particular, the serious diagnoses of carcinoid syndrome, pheochromocytoma, mastocytosis, systemic lupus erythematosus, dermatomyositisand anaphylaxis need to be excluded by laboratory studies. In the article, we present main diseases that dermatologysts should consider when diagnosing rosacea.

scholarly journals A Case of Thrombotic Thrombocytopenia Purpura Associated with Systemic Lupus Erythematosus: Diagnostic Utility of ADAMTS-13 Activity

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Risa Yamada ◽  
Kazuhisa Nozawa ◽  
Takashi Yoshimine ◽  
Yoshinari Takasaki ◽  
Hideoki Ogawa ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Thrombotic Microangiopathy ◽  
Autoimmune Disorder ◽  
Accurate Diagnosis ◽  
Diagnostic Utility ◽  
Systemic Lupus

Thrombotic thrombocytopenia purpura (TTP) caused by a deficiency in ADAMTS-13 activity is considered to involve a subset of thrombotic microangiopathy (TMA). Although concept of TTP is included under the umbrella of TMA, discrimination of TTP from TMA is occasionally difficult in an autoimmune disorder. Herein, we report a case with TTP associated with systemic lupus erythematosus (SLE). In this case, it was difficult to discriminate TTP from TMA and the measurement of ADAMTS-13 activity was useful for obtaining an accurate diagnosis. SLE patients having thrombocytopenia in complication with anemia should be considered a monitoring of ADAMTS-13 activity even though the patients lacked symptoms of TTP related to the microvascular coagulation.

scholarly journals Cutaneous Manifestations of “Lupus”: Systemic Lupus Erythematosus and Beyond

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Elizabeth E. Cooper ◽  
Catherine E. Pisano ◽  
Samantha C. Shapiro
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Treatment ◽  
Treatment Options ◽  
Cutaneous Lupus Erythematosus ◽  
Laboratory Studies ◽  
Systemic Lupus ◽  
Cutaneous Manifestations ◽  
Distinct Disease ◽  
Cutaneous Lupus

Lupus, Latin for “wolf,” is a term used to describe many dermatologic conditions, some of which are related to underlying systemic lupus erythematosus, while others are distinct disease processes. Cutaneous lupus erythematosus includes a wide array of visible skin manifestations and can progress to systemic lupus erythematosus in some cases. Cutaneous lupus can be subdivided into three main categories: acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, and chronic cutaneous lupus erythematosus. Physical exam, laboratory studies, and histopathology enable differentiation of cutaneous lupus subtypes. This differentiation is paramount as the subtype of cutaneous lupus informs upon treatment, disease monitoring, and prognostication. This review outlines the different cutaneous manifestations of lupus erythematosus and provides an update on both topical and systemic treatment options for these patients. Other conditions that utilize the term “lupus” but are not cutaneous lupus erythematosus are also discussed.

scholarly journals A 4-year old presenting with fever and achiness

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110564
Author(s):  
Caroline Plott ◽  
Thomas Gracie ◽  
Courtney Alvis ◽  
Amanda Schlefman ◽  
Robert Dudas
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Correct Diagnosis ◽  
Laboratory Studies ◽  
Systemic Lupus ◽  
Class V ◽  
Pediatric Systemic Lupus Erythematosus ◽  
System Disease ◽  
Membranous Lupus Nephritis ◽  
Onset Systemic Lupus Erythematosus

In children under the age of 5 who have abnormalities in history, physical examination, and laboratory studies indicating multi-system disease, uncovering the correct diagnosis is challenging. Here, we report the course of a 4-year-old girl who presented with a change in behavior, fever, arthralgia, arthritis, and hematuria following three recent hospitalizations for pneumonia and impetigo. Serologic findings were suggestive of a rheumatologic etiology and a renal biopsy was consistent with Membranous Lupus Nephritis Class V which helped secure the diagnosis of pediatric systemic lupus erythematosus. We review the clinical features and diagnostic criteria of early-onset systemic lupus erythematosus and discuss diagnostic considerations and prognosis.

A case of generalized pustular psoriasis caused by hydroxychloroquine in a patient with systemic lupus erythematosus

Lupus ◽  
2019 ◽  
Vol 28 (8) ◽  
pp. 1017-1020 ◽  
Author(s):  
E Shindo ◽  
K Shikano ◽  
M Kawazoe ◽  
T Yamamoto ◽  
N Kusunoki ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Neutrophil Infiltration ◽  
Pustular Psoriasis ◽  
Nucleotide Polymorphisms ◽  
Systemic Lupus ◽  
Single Nucleotide ◽  
Potential Development ◽  
Generalized Pustular Psoriasis ◽  
The Face

Hydroxychloroquine (HCQ) has been used to treat systemic lupus erythematosus (SLE) in Japan since 2015. We herein report a case of SLE that developed generalized pustular psoriasis (GPP) following the administration of HCQ. Twenty-one days after the HCQ treatment, a pustular rash with itching appeared on the auricle, scalp, and forearm, and spread rapidly to the face and body trunk with a high fever and arthralgia. Skin biopsy showed pustule formation under the cornified layer, neutrophil infiltration, the destruction of keratinocytes, and spongiform pustules of Kogoj. The patient was diagnosed with GPP. HCQ was immediately discontinued, the dose of prednisolone (PSL) was increased, and granulocyte and monocyte adsorption apheresis was performed. Her symptoms subsequently disappeared. Since arthralgia relapsed after the tapering of PSL, cyclosporine was added. Although single nucleotide polymorphisms (c.28C>T and c.115+6T>C) in the interleukin (IL)-36RN gene, which encodes the IL-36 receptor antagonist, have frequently been reported in GPP, these mutations were not observed in the present case. The potential development of GPP needs to be considered when administering HCQ to patients with SLE.

scholarly journals Bullous Systemic Lupus Erythematosus Associated with Esophagitis Dissecans Superficialis

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Meera Yogarajah ◽  
Bhradeev Sivasambu ◽  
Eric A. Jaffe
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Skin Lesions ◽  
Esophageal Mucosa ◽  
Systemic Lupus ◽  
Neck Lymph Node ◽  
The Face ◽  
History Of ◽  
The Right ◽  
Pruritic Skin

Bullous systemic lupus erythematosus is one of the rare autoantibody mediated skin manifestation of systemic lupus erythematosus (SLE) demonstrating subepidermal blistering with neutrophilic infiltrate histologically. We present a case of a 40-year-old Hispanic female who presented with a several months’ history of multiple blistering pruritic skin lesions involving the face and trunk, a photosensitive rash over the face and neck, swelling of the right neck lymph node, and joint pain involving her elbows and wrist. Her malady was diagnosed as bullous systemic lupus erythematosus based on the immunological workup and biopsy of her skin lesions. The patient also complained of odynophagia and endoscopy revealed esophagitis dissecans superficialis which is a rare endoscopic finding characterized by sloughing of the esophageal mucosa. The bullous disorders typically associated with esophagitis dissecans superficialis are pemphigus and rarely bullous pemphigoid. However, this is the first reported case of bullous systemic lupus erythematosus associated with esophagitis dissecans superficialis.

scholarly journals Atypical dermatophytosis in a case of systemic lupus erythematosus

2020 ◽  
Vol 11 (e) ◽  
pp. e165.1-e165.3
Author(s):  
Manjunath M Shenoy ◽  
Goutham Kilaru ◽  
Ashmiya Razak ◽  
Malcolm Pinto
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Autoimmune Disorder ◽  
Laboratory Evaluation ◽  
Systemic Lupus ◽  
Cutaneous Manifestations ◽  
Therapeutic Implications ◽  
The Face ◽  
Erythematous Plaques

Systemic lupus erythematosus (SLE) is a multiorgan autoimmune connective tissue disease with many muco-cutaneous manifestations. We report a case of SLE on treatment presented with scaly erythematous plaques on the trunk and extremities and diffuse scaly erythematous macular lesions on the face resembling cutaneous lupus erythematosus. Laboratory evaluation established a diagnosis of tinea corporis with faciei. He responded to long term itraconazole therapy. This case focuses on the modification of tinea in an autoimmune disorder on immunosuppressive therapy and its therapeutic implications.

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