scholarly journals How skin and liver can lead to diagnosis

2021 ◽  
Vol 84 (4) ◽  
pp. 682-683
Author(s):  
P Vande Berg ◽  
A Vande Berg ◽  
E Harkemanne ◽  
C Peeters ◽  
V Havelange ◽  
...  
Keyword(s):  
Bone Marrow Aspiration ◽  
Unknown Origin ◽  
Chronic Myelomonocytic Leukemia ◽  
Skin Nodule ◽  
Pet Ct ◽  
Cutaneous Localization ◽  
Night Sweats ◽  
The Right ◽  
Myelomonocytic Leukemia ◽  
Rule Out

A 73-year-old woman was referred by her hematologist for cholestasis of unknown origin. She was recently diagnosed with chronic myelomonocytic leukemia grade 0 in a context of fatigue, night sweats, weight loss and monocytosis. A PET-CT showed hepatosplenomegaly and multiple centimetric adenopathy. The diagnosis was confirmed by a bone marrow aspiration and biopsy. Interestingly, the evolution of the patient is marked by the appearance of cholestasis and an erythematous firm skin nodule of the right forearm. The skin lesion was biopsied to rule out a cutaneous localization of the patient’s known hemopathy.

scholarly journals Chronic Myelomonocytic Leukemia following Multicentric Castleman Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Feng Li ◽  
Xiaomei Zhang ◽  
Yanting Guo ◽  
Yuandong Zhu ◽  
Yicun Wu ◽  
...  
Keyword(s):  
Lymphoproliferative Disorder ◽  
Pluripotent Stem Cell ◽  
Underlying Mechanism ◽  
Castleman Disease ◽  
Chronic Myelomonocytic Leukemia ◽  
Cell Precursor ◽  
Multicentric Castleman Disease ◽  
Night Sweats ◽  
Systemic Symptoms ◽  
Myelomonocytic Leukemia

Multicentric Castleman disease (MCD) is a rare nonmalignant lymphoproliferative disorder presenting systemic symptoms such as fever, night sweats, fatigue, anemia, effusions, and multifocal lymphadenopathy. The etiology of MCD has not been clarified to date. The coexistence of MCD with chronic myelomonocytic leukemia (CMML) has been rarely reported. Although the pathogenesis remains unclear, this association probably reflects an incidental and fortuitous finding rather than the alteration of a common pluripotent stem cell precursor. Herein, we report on one case of MCD coexisting with CMML and elucidate the underlying mechanism of pathology in some aspects.

Challenges in the diagnosis and management of Granulicatella elegans endocarditis in a 9-year-old child

2021 ◽  
Vol 14 (2) ◽  
pp. e240079
Author(s):  
Victoria Holloway ◽  
George Jacob ◽  
Nicholas Hayes
Keyword(s):  
Pulmonary Atresia ◽  
Unknown Origin ◽  
Autism Spectrum ◽  
High Dose ◽  
Diagnostic Challenge ◽  
Gram Positive Bacteria ◽  
Night Sweats ◽  
European Society Of Cardiology ◽  
The Right ◽  
Specific Symptoms

A 9-year-old child, with a background of repaired pulmonary atresia and Ebstein’s anomaly, presented with fever, night sweats and lethargy. Blood cultures grew Granulicatella elegans, a nutritionally variant Streptococcus and known cause of infective endocarditis (IE). Echocardiogram revealed no clear vegetation, but increased stenosis of the right ventricle to pulmonary artery conduit. The child was successfully managed with high-dose benzylpenicillin, completing 2 weeks in the hospital, and was discharged to complete the final 4 weeks of therapy with ceftriaxone in the community, as per European Society of Cardiology guidance. IE caused by any Granulicatella species is rare, with infection due to G. elegans rarer still. It is a Gram-positive bacteria that presents a diagnostic challenge due to non-specific symptoms at presentation and difficulty in growing the organism on culture medium. We present a case of G. elegans endocarditis in a young child, which illustrates the challenges in managing this condition and the importance of considering atypical organism endocarditis in children presenting with fever of unknown origin, in particular those with a background of congenital cardiac disease. We review the literature on Granulicatella endocarditis, and briefly discuss the challenges of managing this condition in a child with an autism spectrum disorder and learning difficulties.

scholarly journals Pleural effusion in hematological pathology

CytoJournal ◽  
2021 ◽  
Vol 18 ◽  
pp. 3
Author(s):  
Neeraja Yerrapotu ◽  
Abid Rahman ◽  
Ali Gabali ◽  
Vinod B Shidham
Keyword(s):  
Computed Tomography ◽  
Pleural Effusion ◽  
Chronic Myelomonocytic Leukemia ◽  
Computed Tomography Scan ◽  
Atypical Cells ◽  
Night Sweats ◽  
History Of ◽  
Myelomonocytic Leukemia ◽  
Tomography Scan ◽  
Fluid Cytology

A 51-year-old male with a history of chronic myelomonocytic leukemia-2 (CMML-2) presented with fatigue, night sweats, dyspnea, and right-sided chest pain exacerbated by deep breath. Computed tomography scan demonstrated right-sided pleural effusion with atelectasis. Pleural fluid cytology showed reactive mesothelial cells mixed with atypical cells [Figure 1]. The immunostains are performed using the SCIP approach.[1] The atypical cells were immunoreactive for vimentin, CD68, and CD163, while non-immunoreactive for cytokeratin, calretinin, BerEP4, and MOC31.

scholarly journals Burkitt non-Hodgkin lymphoma presenting with mental neuropathy (‘numb chin’ syndrome) in an HIV-positive patient

2017 ◽  
Vol 29 (6) ◽  
pp. 618-620 ◽  
Author(s):  
N Vora ◽  
H Haryee ◽  
JC Dickson ◽  
RF Miller
Keyword(s):  
Hodgkin Lymphoma ◽  
Focal Lesions ◽  
Non Hodgkin Lymphoma ◽  
Lymph Node Imaging ◽  
Positron Emission ◽  
Pet Ct ◽  
Night Sweats ◽  
The Right ◽  
High Index Of Suspicion ◽  
Fdg Pet Ct

Mental nerve neuropathy is usually due to local trauma or dental causes, but may be a manifestation of malignancy. A patient with virologically controlled human immunodeficiency virus (HIV) infection presented with a ‘numb chin’ on the background of long-standing night sweats, malaise and weight loss, worsening respiratory symptoms, and lymphadenopathy. Burkitt non-Hodgkin lymphoma was diagnosed from histology of a lymph node. Imaging (magnetic resonance imaging and 18fluorodeoxyglucose [FDG]-positron emission tomography-computed tomography [PET-CT]) showed abnormal intracranial enhancement of the right mandibular nerve and extensive 18FDG-avid lymphadenopathy above and below the diaphragm, focal lesions in the spleen and within the right mandible. The patient received chemotherapy and remains in clinical and radiological remission seven years later. This case highlights the need for clinicians to maintain a high index of suspicion for underlying malignancy when an HIV-infected patient presents with new onset of a ‘numb chin’. Additionally, it demonstrates the importance of functional 18FDG-PET-CT and neuroimaging in order to identify site(s) of pathology.

Renal Infarction and Pulmonary Embolism in Patient with Myelodysplastic

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Mounia Bendari ◽  
Nouama Bouanani ◽  
Mohamed Amine Khalfaoui ◽  
Maryam Ahnach ◽  
Aziza Laaraj ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Myeloproliferative Neoplasms ◽  
Bone Biopsy ◽  
Bone Marrow Aspiration ◽  
Myeloproliferative Disorders ◽  
Acute Onset ◽  
International Prognostic Scoring System ◽  
Renal Infarction ◽  
The Right ◽  
Enhanced Computed Tomography

The myelodysplastic syndrome-myeloproliferative neoplasms (MDS/MPNs) are defined by a group of heterogeneous hematological malignancies resulting from stem cell−driven clonal growth of pathological hematopoietic progenitors and ineffective hematopoiesis, they are characterized concomitant myelodysplastic and myeloproliferative signs. Myelodysplastic/myeloproliferative disorders have been considered to have a higher risk of thrombus formation.We report a rare case about a 64 years old Moroccan woman, experienced renal infarction (RI) associated with pulmonary embolism as a complication of a myelodysplastic/myeloproliferative disorder.The patient complained of acute-onset severe left flank pain, a contrast-enhanced computed tomography (CT) of the chest and abdomen revealed RI by a large wedge-shaped defect in the right kidney with pulmonary embolism.Biological exam showed deep anemia, the bone marrow aspiration found myelodysplasia.the bone biopsy showed signs of myeloproliferatif disease. The karyotype was normal, BCR-ABL, JAK2, CALR mutations were absents, and MPL mutation was positive. The International Prognostic Scoring System (IPSS-R) was 0, and the patient was included to the low risk group.Anticoagulation therapy was initiated with heparin to treat RI and pulmonary embolism. Three months later, pulmonary embolism had resolved without the appearance of additional peripheral infarction.This case emphasizes the need to consider myelodysplastic/myeloproliferative disorders as a cause of infraction renal and pulmonary embolism.

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