scholarly journals The Role of Monoclonal Antibodies as Biologic Agents in The Evidence Based Treatment of Sino-Nasal Diseases

2018 ◽  
Author(s):  
Öner Özdemir
Keyword(s):  
Monoclonal Antibodies ◽  
Biologic Agents ◽  
Evidence Based ◽  
Evidence Based Treatment ◽  
Nasal Diseases

A review of the evidence to explain pharmacological basis of injection (ab)use of buprenorphine–naloxone tablets

2021 ◽  
Vol 17 (7) ◽  
pp. 141-152
Author(s):  
Tamoud Modak, MD, DM ◽  
Siddharth Sarkar, MD, MRCPsych ◽  
Yatan Pal Singh Balhara, MD
Keyword(s):  
Public Health Problem ◽  
Opioid Use Disorder ◽  
Critical Examination ◽  
Evidence Based ◽  
Major Public Health Problem ◽  
Opioid Use ◽  
Evidence Based Treatment ◽  
Opioid Replacement Therapy ◽  
Pharmacological Basis

Opioid use disorder is a major public health problem, and opioid replacement therapy with buprenorphine (BPN) is a clinically effective and evidence-based treatment for it. To deter misuse of the tablet through the injecting route, BPN coformulated with naloxone (BNX) in 4:1 ratio is available in many countries. Despite this, significant diversion and injecting use of the BNX combination has been reported from across the world. In this article, the pharmacological properties of BPN and BNX and the evidence for their diversion are reviewed. Also, a critical examination is made of the evidence supporting the role of naloxone in reducing the agonist effects of BPN when used through the injecting route. Based on this evidence, a hypothesis explaining the continued diversion of BNX has been proposed.

scholarly journals The Role of Context in the Case of Taro

2016 ◽  
Vol 11 (4) ◽  
pp. 279
Author(s):  
Yoshinobu Kanazawa
Keyword(s):  
Therapeutic Process ◽  
Mechanisms Of Change ◽  
Evidence Based ◽  
Scientific Rigor ◽  
Evidence Based Treatment ◽  
Organizational Issues ◽  
Measurement Tools ◽  
Therapy Sessions

<p align="left">Muto and Mitamura (2015) are to be highly commended for publishing the case study of Taro. The article is notable for its emphasis on documenting what is behaviorally observable and reliably quantifiable. The authors&rsquo; commitment to scientific rigor is laudable. Japanese psychotherapists are strongly advised to use this article as a model of evidence-based treatment in their descriptions of psychotherapy sessions. On the other hand, the reviewer would have liked to see more discussions on contextual factors around Taro, his presenting problems, and his therapy, including therapeutic relationships, Taro&rsquo;s emotions in therapy sessions and the therapist&rsquo;s responses to them, possible conflicts in Taro&rsquo;s family, as well as organizational issues around Taro and his symptoms in his workplace. Measurement tools are available to reliably quantify these variables. Incorporating these measures into the therapist&rsquo;s work with Taro would help readers better understand the therapeutic process and illuminate the mechanisms of change in the case study.</p>

Refractory short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing responsive to anti-calcitonin gene-related peptide monoclonal antibodies: A case report

Cephalalgia ◽  
2020 ◽  
pp. 033310242095455
Author(s):  
Gabriel Bsteh ◽  
Christian Bsteh ◽  
Gregor Broessner
Keyword(s):  
Monoclonal Antibodies ◽  
Case Report ◽  
Treatment Option ◽  
Calcitonin Gene Related Peptide ◽  
Evidence Based ◽  
Conjunctival Injection ◽  
Trigeminal Autonomic Cephalalgia ◽  
Evidence Based Treatment ◽  
Related Peptide ◽  
Calcitonin Gene

Background Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) is a rare but severely disabling variant within the spectrum of trigeminal autonomic cephalalgia lacking evidence-based treatment. Case We report a case of chronic SUNCT in a 67-year-old man refractory to various guideline-conforming treatment attempts responding excellently to galcanezumab. Conclusions This case report indicates that monoclonal antibodies against calcitonin gene-related peptide, specifically galcanezumab, might be a treatment option for SUNCT warranting further investigation.

scholarly journals Role of hysterolaparoscopy in management of infertility a retrospective clinical analysis

2020 ◽  
Vol 9 (11) ◽  
pp. 4437
Author(s):  
Geeta S. Wadadekar ◽  
Dattaprasad B. Inamdar ◽  
Vandana R. Nimbargi
Keyword(s):  
Reproductive Medicine ◽  
Treatment Plan ◽  
Clinical Information ◽  
Clinical Analysis ◽  
Infertility Treatment ◽  
Evidence Based ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Evidence Based Treatment

Background: Diagnosis and treatment of infertility is an elaborate process. The goal of treating clinician is to decide upon the plan of management best suited to the couple by selecting relevant investigations and procedures from available options. Objective was to determine the role of hysterolaparoscopy in the management of infertility.  Methods: This retrospective study was conducted at a tertiary canter (Department of reproductive medicine and surgery) over a period of 12 months-January 2019 to December 2019. Women aged 20-40 years with primary or secondary infertility, except male factor infertility, undergoing hysterolaparoscopy were included. Results: Out of 41 cases, 71.84% patients had primary infertility. Common laparoscopic abnormalities were adhesions (36.5%) and endometriosis (17.07%) Hysteroscopy revealed polyps (9.7%) and intrauterine synechia (4.8%) as common pathologies. The diagnosed pathologies were dealt surgically in the same sitting. Plan of infertility treatment could be outlined in all patients based on intraoperative findings. Conclusion: Hysterolaparoscopy serves both diagnostic and therapeutic purpose. Various pelvic, peritoneal, tubal, endometrial and uterine factors can be diagnosed and treated at the same time. The clinician has to be well versed and skilled in selecting and performing the appropriate surgery. Clinical information gained from hysterolaparoscopy helps in decision making and designing individualized, evidence-based treatment plan can for the patients.

Leadership and implementation of evidence‐based practices

2008 ◽  
Vol 21 (3) ◽  
pp. 168-184 ◽  
Author(s):  
Robert Holmberg ◽  
Mats Fridell ◽  
Patrick Arnesson ◽  
Mia Bäckvall
Keyword(s):  
Job Satisfaction ◽  
Leadership Styles ◽  
Implementation Process ◽  
Functional Space ◽  
Evidence Based ◽  
Content Type ◽  
Evidence Based Treatment ◽  
Leadership Behaviour ◽  
The Impact

PurposeThis paper seeks to investigate the role of leadership styles in the implementation of evidence‐based treatment methods (EBP) for drug abuse and criminal behaviour.Design/methodology/approachThe paper employs a triangulation approach through mail questionnaires to 112 treatment personnel (49 per cent response rate), interviews with 65 employees and managers, observations and feedback workshops.FindingsResponses from treatment personnel involved in the implementation of EBP indicated that their views on their immediate superior's leadership behaviour was significantly related to the perceptions of organisational innovative climate, job satisfaction and work output. Problems with workload, lack of collegial and managerial support and a low priority given to the programmes and treatment integrity were the most common barriers to implementation of the programmes. Effective managers were providing space, time and opportunity for the staff to perform their treatment‐related tasks and to be creative during the implementation process. This functional space had to be continually protected, both vertically from demands from higher levels of the organisation and horizontally from non‐helpful colleagues.Research limitations/implicationsThe correlational design used in this study does not permit conclusions about causality.Practical implicationsImplementation of evidence‐based treatment programmes in clinical settings should pay attention to the impact of leadership styles on the experiences of treatment staff (climate, job‐satisfaction, burnout) and programme outcome. These variables should also be considered in the evaluation of treatment effects. The process of implementation can be seen as a route for learning and innovation, and managers should pay attention to the facilitation of these processes.Originality/valueThe role of leadership in implementation concerns not only production and structure but also learning, creativity and persistency during the process. The triangulation approach in this study also sheds light on the limitations of questionnaires in capturing the dynamics of leadership in human service organisations.

Self-Regulatory Aspects of Bullshitting and Bullshit Detection

2020 ◽  
Vol 51 (4) ◽  
pp. 239-253
Author(s):  
John V. Petrocelli ◽  
Haley F. Watson ◽  
Edward R. Hirt
Keyword(s):  
Evidence Based ◽  
Regulatory Aspects

Abstract. Two experiments investigate the role of self-regulatory resources in bullshitting behavior (i.e., communicating with little to no regard for evidence, established knowledge, or truth; Frankfurt, 1986 ; Petrocelli, 2018a ), and receptivity and sensitivity to bullshit. It is hypothesized that evidence-based communication and bullshit detection require motivation and considerably greater self-regulatory resources relative to bullshitting and insensitivity to bullshit. In Experiment 1 ( N = 210) and Experiment 2 ( N = 214), participants refrained from bullshitting only when they possessed adequate self-regulatory resources and expected to be held accountable for their communicative contributions. Results of both experiments also suggest that people are more receptive to bullshit, and less sensitive to detecting bullshit, under conditions in which they possess relatively few self-regulatory resources.

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