scholarly journals Ways to improve the diagnostics and detection of cervical cancer development and recurrence risk

2021 ◽  
Vol 62 (4) ◽  
pp. 24-27
Author(s):  
K. Tazhibayeva ◽  
A. Sadykova ◽  
D. Tasboltaeva ◽  
A. Ormanov ◽  
G. Kaldygozova
Keyword(s):  
Cervical Cancer ◽  
Radiation Therapy ◽  
Radical Hysterectomy ◽  
Morphological Structure ◽  
Recurrence Risk ◽  
Disease Stage ◽  
First Year ◽  
The Third ◽  
End Of Treatment ◽  
Cervical Cancer Development

th and the third most common female cancer worldwide. The purpose of the study was to determine risk factors and time to progression and recurrence in patients with cervical cancer after complex treatment (neoadjuvant chemotherapy + radical hysterectomy + combined radiation therapy). Methods: This retrospective study involved female patients with stage IB-IIA cervical cancer registered at Shymkent city oncological dispensary in 2011- 2021 (n=883). All patients underwent (n=883) radical hysterectomy with pelvic lymph node dissection. The patients were selected who underwent radiation therapy of the lower pelvis at a dose of ≥40 g. The age-, stage-, and tumor morphological structure-dependent survival factors and recurrence risk were analyzed during the research decade. Results: Direct correlation of the disease stage and the recurrence period was established. The progression was most often 5 to 6 months after treatment. 68.7% of progression and 63.1% of recurrences occurred in the first year and a half after the end of treatment, so this period is considered the most “dangerous” regarding the recurrence risk. 5.3% of patients had a recurrence 19 to 24 months after treatment, 31.5% – after more than two years. Conclusions: In this research, cervical cancer progressed in 74 (10.6%) out of 883 women and recurred in 19 (3.0%). The recurrence was most frequent in women aged 45-50 years (28.4%) and 50-60 years (26.3%).

scholarly journals 258 Design and validation of a recurrence risk predicting score in early stage cervical cancer after radical hysterectomy

2020 ◽  
Author(s):  
Nabil Manzour ◽  
Enrique Chacon ◽  
Nerea Martín-Calvo ◽  
José Ángel Mínguez ◽  
Teresa Castellano ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Radical Hysterectomy ◽  
Early Stage ◽  
Recurrence Risk ◽  
Early Stage Cervical Cancer

scholarly journals From Microbiome to Inflammation: The Key Drivers of Cervical Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Zi-Wei Zhou ◽  
Hui-Zhi Long ◽  
Yan Cheng ◽  
Hong-Yu Luo ◽  
Dan-Dan Wen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Development ◽  
The Third ◽  
Host Body ◽  
Key Drivers ◽  
Cervical Cancer Development ◽  
The Relationship

Cervical cancer is the third leading cause of cancer-related death worldwide. Microbes and hosts form a mutually beneficial symbiosis relationship, and various parts of the host body are microbial habitats. Microbes can trigger inflammation in certain parts of the host body, contributing to cervical cancer development. This article reviews the relationship between cervicovaginal microbes, inflammation and cervical cancer, and discusses the effect of some key cervical microbes on cervical cancer. Finally, probiotic therapy and immunotherapy are summarized.

scholarly journals Vesicovaginal Fistula After Fourteen Years of Pelvic Radiation

2018 ◽  
Vol 13 (2) ◽  
pp. 60-62
Author(s):  
Kenusha Devi Tiwari ◽  
Aruna Karki ◽  
Ganesh Dangal ◽  
Hema Pradhan ◽  
Ranjana Shrestha ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Radiation Therapy ◽  
Radical Hysterectomy ◽  
Vesicovaginal Fistula ◽  
Fistula Repair ◽  
Pelvic Radiation ◽  
Advanced Cervical Carcinoma

Radiation therapy is an effective treatment for cervical cancer. However, of various complications, irradiation sometimes can cause formation of fistula between vagina and bladder and or rectum compromising the quality of life. Pelvic radiation is the primary cause of delayed vesicovaginal fistula with incidence of 13% in well-resourced countries and 0.2% in low resourced countries. Majority of them become apparent 1.5-2 years after completion of radiotherapy and can occur even up-to 20-30 years after the original insult. A 63 years’ female visited our outpatient department for involuntary loss of urine per vagina for 1.5 years. She had undergone radical hysterectomy and radiotherapy 16 years ago for an advanced cervical carcinoma. With positive dye test, she had vesicovaginal fistula with Goh classification of 1biii. She underwent simple fistula repair via vaginal approach. After three weeks of catheterization, successful closure was achieved.

Radical hysterectomy for recurrent cervical cancer following radiation therapy

1987 ◽  
Vol 27 (3) ◽  
pp. 316-322 ◽  
Author(s):  
Stephen C. Rubin ◽  
William J. Hoskins ◽  
John L. Lewis
Keyword(s):  
Cervical Cancer ◽  
Radiation Therapy ◽  
Radical Hysterectomy ◽  
Recurrent Cervical Cancer

Radical hysterectomy for recurrent or persistent cervical cancer following radiation therapy

1999 ◽  
Vol 9 (4) ◽  
pp. 295-301 ◽  
Author(s):  
A. Maneo ◽  
F. Landoni ◽  
G. Cormio ◽  
A. Colombo ◽  
C. Mangioni
Keyword(s):  
Cervical Cancer ◽  
Radiation Therapy ◽  
Radical Hysterectomy

scholarly journals Radical treachelectomy in treatment of early stages of cervical cancer

2008 ◽  
Vol 55 (4) ◽  
pp. 93-97
Author(s):  
K. Jeremic ◽  
S. Petkovic ◽  
A. Stefanovic ◽  
M. Gojnic ◽  
M. Maksimovic ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Radiation Therapy ◽  
Radical Hysterectomy ◽  
Diagnostic Method ◽  
Early Stage ◽  
Radical Trachelectomy ◽  
Residual Cancer ◽  
Early Stage Cervical Cancer ◽  
Early Cervical Cancer

The aim of the study was to determine if radical trachelectomy with pelvic lymphonodectomy could be a method for treatment of early cervical cancer to preserve fertility. We examined 12 patients who were operatively treated from 1996. to 2006. year. Diagnostic method for cervical cancer was histologic examination, cone or biopsy. Histologic condition was planocelular carcinoma well differenced. Two of the patients had Ia1 stage, seven had Ia2, and three of them had Ib1. We performed abdominal radical trachelectomy with pelvic lymphonodectomy. Resectional edges were patohistologically analyzed ex tempore, as well as lymphonodi, selectively. According to ex tempore analysis we determined if the radical trachelectomy should be done. In one patient resectional edges were positive, so she underwent radical hysterectomy. Postoperatively we found a positive lymphonodus in one patient, so we continued radiation therapy. In twoyear follow-up period we did not find any sign of residual cancer. We concluded that radical trachelectomy with pelvic lymphonodectomy could be appropriate method for treatment of early stage cervical cancer.

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