scholarly journals The Effect of Bisphenol A on the Histological Parameters of Male Rat Prefrontal Area

2021 ◽  
Vol 8 (2) ◽  
pp. 51-56
Author(s):  
Farid Habibi ◽  
Shabnam Movassaghi ◽  
Amirhossein saeinia ◽  
Mohammad Mahdi Nazarnejad ◽  
Shabnam Abdi ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Male Rat ◽  
Prefrontal Area

scholarly journals Male-specific suppression of hepatic microsomal UDP-glucuronosyl transferase activities toward sex hormones in the adult male rat administered bisphenol A

2002 ◽  
Vol 368 (3) ◽  
pp. 783-788 ◽  
Author(s):  
Noriaki SHIBATA ◽  
Junya MATSUMOTO ◽  
Ken NAKADA ◽  
Akira YUASA ◽  
Hiroshi YOKOTA
Keyword(s):  
Bisphenol A ◽  
Mrna Expression ◽  
Sex Hormones ◽  
Adult Male ◽  
Endocrine Disruptor ◽  
Liver Microsomes ◽  
Female Rats ◽  
Male Rats ◽  
Male Rat ◽  
Blotting Analysis

Various adverse effects of endocrine disruptors on the reproductive organs of male animals have been reported. We found that UDP-glucuronosyltransferase (UGT) activities towards bisphenol A, testosterone and oestradiol were significantly decreased in liver microsomes prepared from adult male Wistar rats administered with the endocrine disruptor bisphenol A (1mg/2 days for 2 or 4 weeks). However, suppression of the transferase activities was not observed in female rats, even after bisphenol A treatment for 4 weeks. Diethylstilbestrol, which is well known as an endocrine disruptor, had the same effects, but p-cumylphenol had no effect on UGT activities towards sex hormones. Co-administration of an anti-oestrogen, tamoxifen, inhibited the suppression of the transferase activities by bisphenol A. Western blotting analysis showed that the amount of UGT2B1, an isoform of UGT which glucuronidates bisphenol A, was decreased in the rat liver microsomes by the treatment. Northern blotting analysis also indicated that UGT2B1 mRNA in the liver was decreased by bisphenol A treatment. The suppression of UGT activities, UGT2B1 protein and UGT2B1 mRNA expression did not occur in female rats. The results indicate that bisphenol A treatment reduces the mRNA expression of UGT2B1 and other UGT isoforms that mediate the glucuronidation of sex hormones in adult male rats, and this suggests that the endocrine balance may be disrupted by suppression of glucuronidation.

scholarly journals Fetal bisphenol A and ethinylestradiol exposure alters male rat urogenital tract morphology at birth: Confirmation of prior low-dose findings in CLARITY-BPA

2020 ◽  
Vol 91 ◽  
pp. 131-141 ◽  
Author(s):  
Kristen S. Uchtmann ◽  
Julia A. Taylor ◽  
Barry G. Timms ◽  
Richard W. Stahlhut ◽  
Emily A. Ricke ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Low Dose ◽  
Urogenital Tract ◽  
Male Rat

scholarly journals Rescue effects of prenatal melatonin administration against bisphenol A- induced perturbations of reproductive and thyroid activities in male rat offsprings

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Kamel M. A. Hassanin ◽  
Shawky S. Ibrahim ◽  
Ahmed Abdel-Wahab ◽  
Dina M. M. H. EL.Kossi ◽  
AbdelRazik H. Abdel-Razik
Keyword(s):  
Bisphenol A ◽  
Male Rat ◽  
Melatonin Administration

scholarly journals Comparison of Conjugative Activity, Conversion of Bisphenol A to Bisphenol A Glucuronide, in Fetal and Mature Male Rat.

2000 ◽  
Vol 46 (4) ◽  
pp. 269-274 ◽  
Author(s):  
Hidekazu Miyakoda ◽  
Masako Tabata ◽  
Sukeo Onodera ◽  
Ken Takeda
Keyword(s):  
Bisphenol A ◽  
Mature Male ◽  
Male Rat

scholarly journals High butter-fat diet and bisphenol A additively impair male rat spermatogenesis

2017 ◽  
Vol 68 ◽  
pp. 191-199 ◽  
Author(s):  
Pheruza Tarapore ◽  
Max Hennessy ◽  
Dan Song ◽  
Jun Ying ◽  
Bin Ouyang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Male Rat ◽  
Butter Fat ◽  
Rat Spermatogenesis

Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal N-methyl-d-aspartate receptors in the hippocampus

2021 ◽  
pp. 074823372098462
Author(s):  
Chong Wang ◽  
Yao Shu ◽  
Li Xu ◽  
Qiling Liu ◽  
Bei Zhang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Learning And Memory ◽  
Maternal Exposure ◽  
Male Offspring ◽  
Male Rat ◽  
Control Group ◽  
Sprague Dawley ◽  
Expression Levels ◽  
Rat Offspring ◽  
Sprague Dawley Rats

Bisphenol A (BPA), a component of polycarbonate and epoxy resins, has been reported to induce learning and memory deficits. However, the mechanisms have not been fully elucidated. Growing evidence has suggested that N-methyl-d-aspartate receptors (NMDARs) are involved in cognitive impairments. In this study, BPA was administered to female Sprague–Dawley rats (six per dose group) at concentrations of 0 (control), 4, 40, and 400 μg/kg·body weight/day from gestation day 1 through lactation day 21. Spatial learning was evaluated using the Morris water maze on postnatal day 22. Expression levels of NMDARs were determined using real-time polymerase chain reaction and Western blot. The results showed that male offspring exposed to BPA exhibited increased latency in reaching the platform and reduced time in the target quadrant, and the number of crossing the platform was less, as compared with the control group. The mRNA and protein expression levels of NMDARs in the hippocampus were significantly downregulated when compared with the control group of male offspring. The data showed that maternal exposure to BPA at low dosage can cause cognitive deficits in male rat offspring, probably due to a decrease in NMDARs in the hippocampus.

scholarly journals Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver

1999 ◽  
Vol 340 (2) ◽  
pp. 405-409 ◽  
Author(s):  
Hiroshi YOKOTA ◽  
Hidetomo IWANO ◽  
Mari ENDO ◽  
Tsutomu KOBAYASHI ◽  
Hiroki INOUE ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Rat Liver ◽  
Northern Blot Analysis ◽  
Glucuronic Acid ◽  
Liver Microsomes ◽  
Male Rat ◽  
Rat Liver Microsomes ◽  
Crystalline Compound ◽  
Udp Glucuronosyltransferase

Bisphenol A, an environmental oestrogenic chemical, was found to conjugate highly with glucuronic acid in male rat liver microsomes studied in vitro. In the various isoforms tested (1A1, 1A3, 1A5, 1A6, 1A7 and 2B1), glucuronidation of bisphenol A and of diethylstilboestrol, a synthetic crystalline compound possessing oestrogenic activity and known to be glucuronidated by liver microsomes, was catalysed by an isoform of UDP-glucuronosyltransferase (UGT), namely UGT2B1, which glucuronidates some endogenous androgens. UGT activity towards bisphenol A in liver microsomes and in UGT2B1 expressed in yeast AH22 cells (22.9 and 0.58 nmol/min per mg of microsomal proteins respectively) was higher than that towards diethylstilboestrol (75.0 and 4.66 pmol/min per mg of microsomal proteins respectively). UGT activities towards both bisphenol A and diethylstilboestrol were distributed mainly in the liver but were also observed at substantial levels in the kidney and testis. Northern blot analysis disclosed the presence of UGT2B1 solely in the liver, and about 65% of the male rat liver microsomal UGT activities towards bisphenol A were absorbed by the anti-UGT2B1 antibody. These results indicate that bisphenol A, in male rat liver, is glucuronidated by UGT2B1, an isoform of UGT.

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