Exploring the effect of Naringenin against Cadmium Induced Neurotoxicity in mice model

2021 ◽  
pp. 4053-4059
Author(s):  
Agrima Srivastava ◽  
Himani Awasthi ◽  
Dipti Srivastava ◽  
Zeeshan Fatima ◽  
Vivek Srivastava
Keyword(s):  
Oxidative Stress ◽  
Memory Impairment ◽  
Cadmium Chloride ◽  
Memory Function ◽  
Brain Homogenate ◽  
Mice Model ◽  
Daily Consumption ◽  
Elevated Plus Maze Test ◽  
Cholinergic Dysfunction ◽  
Plus Maze

Bioactive flavonoid Naringenin has very high nutritional value. Several investigations suggested that supplementation of this bioactive flavonoid is beneficial for health. Naringenin have been found in variety of herbs and fruits which are used for daily consumption like citrus species, tomatoes and figs. This study aimed to explore the effect of flavonoid naringenin on oxidative damage, memory impairment and cholinergic dysfunction induced by Cadmium chloride (5mg/kg p.o) in mice. In this experiment naringenin (20 and 40 mg/kg, p.o.) was given orally for the duration of 28 days in Swiss mice. Memory function was assessed by using elevated plus maze test and morris water maze. Cholinergic function and oxidative stress were estimated in brain homogenate after behavioral study. It was found that naringenin improved memory impairment in cadmium chloride treated mice. Naringenin increases the level of reduced glutathione (GSH) and decreases the level of malondialdehyde (MDA) in brain, helps in memory improvement and decrease oxidative stress.

scholarly journals Emilia coccinae (SIMS) G Extract improves memory impairment, cholinergic dysfunction, and oxidative stress damage in scopolamine-treated rats

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Harquin Simplice Foyet ◽  
Hervé Hervé Ngatanko Abaïssou ◽  
Eglantine Wado ◽  
Emmanuel Asongalem Acha ◽  
Ciobica Alin
Keyword(s):  
Oxidative Stress ◽  
Memory Impairment ◽  
Cholinergic Dysfunction ◽  
Stress Damage ◽  
And Oxidative Stress

scholarly journals Mangifera indicaFruit Extract Improves Memory Impairment, Cholinergic Dysfunction, and Oxidative Stress Damage in Animal Model of Mild Cognitive Impairment

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jintanaporn Wattanathorn ◽  
Supaporn Muchimapura ◽  
Wipawee Thukham-Mee ◽  
Kornkanok Ingkaninan ◽  
Sakchai Wittaya-Areekul
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Impairment ◽  
Cholinergic Neurons ◽  
Protective Agent ◽  
Cholinergic Dysfunction ◽  
Stress Damage ◽  
And Oxidative Stress

To date, the effective preventive paradigm against mild cognitive impairment (MCI) is required. Therefore, we aimed to determine whetherMangifera indicafruit extract, a substance possessing antioxidant and cognitive enhancing effects, could improve memory impairment, cholinergic dysfunction, and oxidative stress damage in animal model of mild cognitive impairment. Male Wistar rats, weighing 180–200 g, were orally given the extract at doses of 12.5, 50, and 200 mg·kg−1BW for 2 weeks before and 1 week after the bilateral injection of AF64A (icv). At the end of study, spatial memory, cholinergic neurons density, MDA level, and the activities of SOD, CAT, and GSH-Px enzymes in hippocampus were determined. The results showed that all doses of extract could improve memory together with the decreased MDA level and the increased SOD and GSH-Px enzymes activities. The increased cholinergic neurons density in CA1 and CA3 of hippocampus was also observed in rats treated with the extract at doses of 50 and 200 mg·kg−1BW. Therefore, our results suggested thatM. indica, the potential protective agent against MCI, increased cholinergic function and the decreased oxidative stress which in turn enhanced memory. However, further researches are essential to elucidate the possible active ingredients and detail mechanism.

Melatonin Rescue Oxidative Stress-Mediated Neuroinflammation/ Neurodegeneration and Memory Impairment in Scopolamine-Induced Amnesia Mice Model

2018 ◽  
Vol 14 (2) ◽  
pp. 278-294 ◽  
Author(s):  
Tahir Muhammad ◽  
Tahir Ali ◽  
Muhammad Ikram ◽  
Amjad Khan ◽  
Sayed Ibrar Alam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Memory Impairment ◽  
Mice Model

scholarly journals CANDESARTAN REVERSES MEMORY DEFICIT CAUSED BY COLCHICINE INDUCED CHOLINERGIC DYSFUNCTION AND OXIDATIVE STRESS

2017 ◽  
Vol 9 (9) ◽  
pp. 184
Author(s):  
Himani Awasthi ◽  
H. H. Siddiqui
Keyword(s):  
Oxidative Stress ◽  
Memory Impairment ◽  
Ache Activity ◽  
Cholinergic Neurons ◽  
Preventive Treatment ◽  
Memory Deficit ◽  
Standard Drug ◽  
Cholinergic Function ◽  
Nitrite Level ◽  
Cholinergic Dysfunction

Objective: We sought to investigate the protective activity of candesartan against memory impairment, oxidative stress and cholinergic dysfunction induced by activation of the central renin-angiotensin system.Methods: Male Swiss albino mice were divided into eight groups. Group 1 received vehicle (1.0% w/v gum acacia), orally for 14 d. Group 2 received intracerebrally (i. c.) artificial cerebrospinal fluid (aCSF, the vehicle of colchicine) and treated with vehicle for 14 d. Group 3, 4 and 5 injected with i. c. colchicine in the doses of 1µg, 2µg, 3µg respectively and treated with vehicle for 14 d. Group 6 and 7 received i. c colchicine (3 µg) and treated with candesartan (0.05 and 0.1 mg/kg respectively) orally for 14 d. Group 8 received i. c colchicine (3 µg) and treated with standard drug donepezil 5 mg/kg (PO) for 14 d.Learning and memory behavior was assessed by using morris water maze. Biochemical parameters of oxidative stress and cholinergic function were estimated in the brain on day 18. Parameters of oxidative stress and cholinergic function were estimated after the completion of behavioral studiesResults: Treatment with a higher dose of colchicines (3µg/mice) caused memory deficit as shown by no significant decrease in escape latency time throughout all the sessions. Results of biochemical estimation showed a marked increase in malondialdehyde (MDA), nitrite level, reduced glutathione (GSH) level, cholinotoxic effect of colchicines has been correlated by marked decrease in acetyl cholinesterase (AChE) activity. Colchicine in a dose of 3 µg/mice has been validated. Pretreatment with candesartan in doses 0.05 and 0.1 mg/kg reverses oxidative stress which can be measured by decreased MDA, nitrite level and increased GSH level. Increased AChE activity may imply protection of cholinergic neurons hence improvement in learning and memory behavior. Conclusion: Preventive treatment with angiotensins receptor blocker, candesartan showed that memory impairment induced by colchicines may be mediated by alteration of central rennin angiotensins system and loss of cholinergic neurons. This study highlighted a number of clinical findings which support marked neuroprotection by blocked of the central AT1 receptor.

Antioxidant Activities of Dichrocephala integrifolia (Linn.f.) O. Kuntze (Asteraceae) in a Mice Model of D-Galactose-Induced Oxidative Stress and Accelerated Aging

2017 ◽  
Vol 8 ◽  
pp. 41-53
Author(s):  
Emégam Nadège Kouémou ◽  
Agathe Fotio Lambou ◽  
Mireille Sylviane Dongmo Nguepi ◽  
Agnès Carolle Ouafo ◽  
Simon Palé ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Elevated Plus Maze ◽  
Antioxidant Activities ◽  
Folk Medicine ◽  
Accelerated Aging ◽  
Mice Model ◽  
Neuroprotective Effects ◽  
Learning Deficits ◽  
Plus Maze ◽  
And Oxidative Stress

Dichrocephala integrifolia is a plant widely used in folk medicine in Africa to treat central nervous diseases such as dementia. In the present study, we evaluated the effect of the leave’s decoction of Dichrocephala integrifolia against D-galactose-induced neurotoxicity, oxidative stress and accelerated aging in mice. D-galactose (100 mg/ kg sc), was chronically injected daily to mice during 42 consecutive days after pretreatment with distilled water (10 ml/kg) or the decoction of D. integrifolia (35; 87.5; 175 or 350 mg/kg p.o) or vitamin C (100 mg/kg p.o). Following behavioral tasks (Open Field, Elevated Plus Maze and Morris Water Maze), animals were sacrificed on day 43 and their brains were used to evaluate some biochemical parameters of oxidative stress (malondialdehyde, nitrite oxide and reduced glutathione) and for histopathological assessments. The results of this study showed that a pretreatment of animals with the decoction of D. integrifolia at the doses of 87.5 and 175 mg/kg significantly (p˂0.05) reversed learning deficits, recall of memories and oxidative stress induced by D-galactose. The decoction of D. integrifolia also prevented neurogeneration in the dentate gyrus induced by D-galactose. These results indicated that D. integrifolia possesses neuroprotective effects against D-galactose-induced senescence, probably due to its antioxidant capacities and this can at least explain the wide use of this plant in traditional medicine in Cameroon in the prevention and treatment of dementia.

Safflower (Carthamus tinctorius L.) seed attenuates memory impairment induced by scopolamine in mice via regulation of cholinergic dysfunction and oxidative stress

2019 ◽  
Vol 10 (6) ◽  
pp. 3650-3659 ◽  
Author(s):  
Ji Hyun Kim ◽  
Mei Tong He ◽  
Min Jo Kim ◽  
Chang Yeol Yang ◽  
Yu Su Shin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Herbal Medicine ◽  
Memory Impairment ◽  
Carthamus Tinctorius ◽  
Seed Extract ◽  
Safflower Seed ◽  
Cholinergic Dysfunction ◽  
And Oxidative Stress

Safflower seed extract containing serotonin and its derivatives improves scopolamine-induced memory impairment, it could be a promising herbal medicine for the treatment of dementia.

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