A case of anaphylactic shock induced by sugammadex in China

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Wei Pan ◽  
◽  
Chen Xi ◽  
Wang yongqiang ◽  
Yuan Lan ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Neuromuscular Blockade ◽  
Inclusion Complexes ◽  
Anaphylactic Reaction ◽  
Anaphylactic Shock ◽  
Junior Doctor ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Drugs ◽  
Medical University

Sugammadex, an antagonist of neuromuscular blocking drugs, was used to rapidly reverse rocuronium induced neuromuscular blockade by encapsulating free rocuronium molecules as inclusion complexes. Because it can enhance the rapid recovery after surgery, summadex is gradually used in clinical. There are relatively few reports about anaphylactic reaction to it. We will present a case of severe anaphylactic shock induced by summadex, as the first in China. Author biography: At present, Wei pan is a junior doctor in Shuguang Hospital Affiliated to Shanghai University of traditional Chinese medicine. She graduated from the anesthesia College of Xuzhou Medical University with a master's degree at the age of 27.

scholarly journals Analysis of Anaphylactic Shock Caused by 17 Types of Traditional Chinese Medicine Injections Used to Treat Cardiovascular and Cerebrovascular Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Yu-Jiao Guo ◽  
De-Wang Wang ◽  
Ling Meng ◽  
Yong-Qing Wang
Keyword(s):  
Gender Differences ◽  
Chinese Medicine ◽  
High Risk ◽  
Traditional Chinese Medicine ◽  
Anaphylactic Shock ◽  
Age Groups ◽  
Cerebrovascular Diseases ◽  
Clinical Safety ◽  
Chinese Herbal ◽  
Allergic Shock

Several reports describing anaphylactic shock following treatment of cardiovascular and cerebrovascular diseases with Chinese herbal injections were described. Our analysis of these reports showed that anaphylactic shock caused by traditional Chinese medicine (TCM) injections for the treatment of cardiovascular and cerebrovascular diseases is common but also sometimes fatal. Therefore, we proposed the following four suggestions for improving the clinical safety of delivering Chinese herbal injections and reducing the occurrence of allergic shock. First, patients with cardiovascular and cerebrovascular diseases are at high risk, so they should only be given TCM injections after a doctor’s diagnosis and approval. Second, people in allergic groups can suffer anaphylactic shock, so vigilance is important in the treatment of all age groups, although even more caution should be exercised when treating children or elderly people. In fact, TCM injections may not be appropriate for those age groups, so that they should be carefully considered before treatment. Third, no significant gender differences have been noted in patients with anaphylactic shock, so all patients should be carefully monitored, irrespective of gender. Fourth, the timeframe in which different drugs cause anaphylactic shock varies; thus, patients should be observed as long as possible.

Neuromuscular Blockers and Reversal Agents

2019 ◽  
Author(s):  
Kristen Flight ◽  
Jennifer J Yang ◽  
Lindsay M Urben ◽  
Michael J Schontz
Keyword(s):  
Neuromuscular Blockade ◽  
Neuromuscular Transmission ◽  
Muscle Relaxation ◽  
Neuromuscular Blocking ◽  
Neuromuscular Monitoring ◽  
Clinical Effects ◽  
Duration Of Action ◽  
Residual Neuromuscular Blockade ◽  
Neuromuscular Blocking Drugs ◽  
Reversal Agents

Neuromuscular blocking drugs, which include depolarizing and nondepolarizing drugs, are used to facilitate intubation and provide skeletal muscle relaxation during surgery and in the intensive care unit. The agents differ in their mechanism, duration of action, side-effect profile, and metabolism. Succinylcholine is the only depolarizing agent in clinic use and is typically used for emergent control of the airway, rapid sequence intubations, and short surgical procedures. The risk of hyperkalemia in certain clinical conditions and risk of malignant hyperthermia in susceptible individuals limit the use of succinylcholine in specific patient populations. Nondepolarizing agents vary in their duration of action, but all provide muscle relaxation for a longer duration than succinylcholine. Clinical effects of neuromuscular blocking drugs can be assessed with neuromuscular monitoring, although there is significant variability among providers in the regular use of neuromuscular monitoring. Reversal agents are used to restore neuromuscular transmission, as residual neuromuscular blockade after extubation has been associated with multiple adverse events, including hypoxemia, atelectasis, and aspiration. Sugammadex is an encapsulating agent capable of immediately reversing the effects of rocuronium-induced neuromuscular blockade that will likely impact the way many providers administer rocuronium and may decrease the future use of succinylcholine. This review contains 4 figures, 6 tables, and 41 references. Keywords: hyperkalemia, neuromuscular monitoring, neuromuscular transmission, nondepolarizing neuromuscular blocking agents, residual neuromuscular blockade, reversal agents, succinylcholine sugammadex, sugammadex

Modern Chinese Use of Tcm as Seen on a Student Elective

1995 ◽  
Vol 13 (2) ◽  
pp. 100-108 ◽  
Author(s):  
Martin Jones ◽  
Stuart Murray
Keyword(s):  
Clinical Practice ◽  
Chinese Medicine ◽  
Medical Students ◽  
Traditional Chinese Medicine ◽  
Medical Treatment ◽  
Western Medicine ◽  
Theory And Practice ◽  
Modern Chinese ◽  
Elective Period ◽  
Medical University

The authors, medical students of Bristol University, spent their elective period of almost six weeks during September and October 1993 in the Acupuncture Department of the First Teaching Hospital of Beijing Medical University. The aim of the elective was to see traditional Chinese medicine (TCM) in clinical practice, especially in conjunction with western medicine, and to try to learn the fundamentals of the theory and practice of TCM. This report details the teaching received and discusses the modern Chinese attitudes to medical treatment and TCM in particular.

Traditional Chinese Medicine at Xian Medical University

1998 ◽  
Vol 16 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Hoo Kee Tsang
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Medical Training ◽  
Diagnostic Techniques ◽  
The Other ◽  
Social Aspects ◽  
Chinese People ◽  
Treatment Techniques ◽  
The University ◽  
Medical University

One aim of the student elective during medical training is to see different cultural and social aspects of practice. This article concerns a student visit from the University of Wales College of Medicine to the Imperial City of Xi'an in China, which offers a medical school with teaching in both traditional Chinese medicine and Western medicine. The visiting student can learn of the traditional theories and methods of diagnosis and have a chance to see and use treatment techniques such as acupuncture, moxibustion, cupping, herbal medicine, Chinese massage and qigong. The Chinese people in general use both Western and traditional medicine, trying one and switching to the other if the first is ineffective, and Chinese traditional doctors make use of Western diagnostic techniques when necessary.

Anaphylactic shock induced byCodonopsis lanceolata, traditional Chinese medicine in a patient with allergic rhinitis

Allergy ◽  
2008 ◽  
Vol 63 (10) ◽  
pp. 1406-1407 ◽  
Author(s):  
G.-Y. Hur ◽  
G.-S. Choi ◽  
H.-J. Park ◽  
Y.-M. Ye ◽  
H.-S. Park
Keyword(s):  
Allergic Rhinitis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Anaphylactic Shock

An Investigation into the Use of Traditional Chinese Medicine in the Treatment of Orofacial Disorders

1997 ◽  
Vol 15 (1) ◽  
pp. 43-48 ◽  
Author(s):  
F Au ◽  
J Cresswell
Keyword(s):  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
General Hospital ◽  
Dental School ◽  
Case Histories ◽  
Traditional Herbal Medicine ◽  
Basic Principles ◽  
Treatment Techniques ◽  
Medical University

While on student elective from the Dental School of Bristol University, the authors had the chance to study the basic principles of traditional Chinese medicine and to observe the treatment of orofacial disease in a modern general hospital in Shanghai and in a specialist stomatological hospital at Beijing Medical University. The background to traditional herbal medicine and various forms of acupuncture encountered during their visit is discussed, as are some case histories. They report that clinical experience in China suggests that the combination of traditional Chinese and Western treatment techniques offers better results than either method alone.

scholarly journals Safety Concerns of Traditional Chinese Medicine Injections Used in Chinese Children

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Liping Tan ◽  
Mujin Li ◽  
Ying Lin
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Anaphylactic Shock ◽  
Proportional Reporting Ratio ◽  
Adult Population ◽  
Paediatric Population ◽  
Chinese Children ◽  
Minimal Risk ◽  
Chi Square ◽  
Minimum Criteria

Objective. To explore risks underlying traditional Chinese medicine (TCM) injection-related adverse drug reactions (ADRs) in Chinese children, and to discuss the implications of postmarketing reevaluation studies. Methods. We identified potential cases of exposure to TCM injections for children (<18 years of age) and adults (18 years and upwards) from database of ADRs. First, the associations between TCM injection-related ADRs and three administration routes (i.e., intravenous or intramuscular administration, oral administration, and external use) and the imbalance of TCM injection-related ADRs between the paediatric and adult populations were tested using the Chi-square (χ2) test. Second, the proportional reporting ratio (PPR) was applied to identify statistically significant associations between drugs and anaphylactic shock in the paediatric population. Results. The χ2 test revealed that the highest frequency of paediatric ADRs was due to 5 types of herbal injections (i.e., Shuanghuanglian (SHL), Yuxingcao (YXC), Qingkailing (QKL), Xiyanping (XYP), and Reduning (RDN) herbal injections) (P<0.000), and the reports of ADRs attributed to the XYP and RDN herbal injections in children accounted for a greater proportion than the reports for adults (P<0.000). The PPR identified 5 types of herbal injections-anaphylactic shock pairs (i.e., the SHL, XYP, QKL, YXC, and Fufang Danshen herbal injections) that met the minimum criteria (i.e., a PPR of at least 2 and χ2 of at least 4 and three or more cases), which suggested that TCM injections were significantly associated with anaphylactic shock. Conclusions. TCM injections pose graver risks to the paediatric population than the adult population. To achieve optimal benefits and minimal risk to children treated with TCM injections, we suggest reevaluating the effectiveness and safety, monitoring the risks, and promoting rational use of TCM injections in Chinese children.

scholarly journals Corrigendum on: Wang H, Chen C, Li J, Yang X, Zhang H and Wang Z. Modified first dorsal metacarpal artery island flap for sensory reconstruction of thumb pulp defects. J Hand Surg Eur. 2016, 41: 177–84.

2016 ◽  
Vol 41 (4) ◽  
pp. 462-462
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
North China ◽  
Hand Surgery ◽  
University Of Technology ◽  
Pr China ◽  
Dorsal Metacarpal Artery ◽  
Medical University ◽  
Published Paper ◽  
Sensory Reconstruction

The authors apologise for an error in the presentation of the affiliations of the authors of this published paper. The correct details are: Hui Wang1,2*, Chao Chen3*, Jun Li4, Xiaoxi Yang5, Hui Zhang1,6, Zhiqiang Wang1,7 1Graduate School, Southern Medical University, Guangzhou, Guangdong, PR China 2The department of Hand Surgery, The Second Hospital of Tangshan, Tangshan, Hebei, PR China 3The department of Orthopedics, Chinese PLA General Hospital, Beijing, PR China 4The emergency department, The Second Hospital of Tangshan, Tangshan, Hebei, PR China 5The department of traditional Chinese Medicine, College of traditional Chinese Medicine, North China University of Technology, Tangshan, Hebei, PR China 6The department of Joint Surgery, The Second Hospital of Tangshan, Tangshan, Hebei, PR China 7The department of Orthopaedics, Affiliated Hospital, North China University of Technology, Tangshan, Hebei, 063000, PR China *Hui Wang and Chao Chen contributed equally to this work.

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