Hypertriglyceridemia induced pancreatitis: An increasing cause of acute pancreatitis: A district hospital experience

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Hnin Sanda ◽  
◽  
Bashir Mahamud ◽  
Shrini Patel Patel ◽  
Noha Meneissy ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
District Hospital ◽  
Serum Triglyceride ◽  
Causative Factor ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Hospital Experience

Hypertriglyceridemia is becoming an increasing causative factor of acute pancreatitis. HTG is characterised by the presence of serum triglyceride greater than 1.7 mmol/l (>150 mg/dL). HTG induced acute pancreatitis is associated with high morbidity and mortality and if not treated timely

Early immunosuppression – Timely protective response or earlier prognosis of high morbidity and mortality in patients with acute pancreatitis

Pancreatology ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. S38-S39
Author(s):  
Georgi Minkov ◽  
Krasimira Halacheva ◽  
Stoyan Nikolov ◽  
Evgeni Dimitrov ◽  
Alen Petrov ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Protective Response

scholarly journals Acute necrotising pancreatitis – early management in the district general hospital and tertiary hepato-pancreatico-biliary unit

2018 ◽  
Vol 20 (3) ◽  
pp. 263-267
Author(s):  
Rajiv P Lahiri ◽  
Nariman D Karanjia
Keyword(s):  
Acute Pancreatitis ◽  
Nutritional Support ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Early Management ◽  
Surgical Emergency ◽  
High Dependency ◽  
Necrotising Pancreatitis ◽  
Acute Necrotising Pancreatitis ◽  
Acute Necrotising

Acute pancreatitis is a common general surgical emergency presentation. Up to 20% of cases are severe and can involve necrosis with high associated morbidity and mortality. It is most commonly due to gallstones and excess alcohol consumption. All patients with acute pancreatitis need to be scored for severity and patients with severe acute pancreatitis should be managed on the high dependency unit. The mainstay of early treatment is supportive, with care to ensure strict fluid balance and optimisation of end organ perfusion. There is no role for early antibiotic use in acute necrotising pancreatitis and antibiotics should only be used in the presence of positive cultures. Nutritional support is vitally important in improving outcomes in necrotising pancreatitis. This should ideally be provided enterally using an naso-jejunal tube if the patient cannot tolerate oral intake. Patients with significant early necrosis, persisting organ dysfunction, infected walled off necrosis requiring intervention or haemorrhagic pancreatitis should be referred to a regional hepato-pancreatico-biliary unit for advice or transfer. Percutaneous and endoscopic necrosectomy has replaced open surgery due to improved outcomes. Acute necrotising pancreatitis remains a complex surgical emergency with high morbidity and mortality that requires a multidisciplinary approach to attain optimum outcomes. The mainstay of treatment is supportive care and nutritional support. Patients with significant pancreatic necrosis or infected collections requiring drainage require input from a tertiary HPB unit to guide management.

scholarly journals An enigmatic triad of acute pancreatitis, diabetic ketoacidosis and hypertriglyceridaemia: who is the culprit?

2019 ◽  
Vol 12 (7) ◽  
pp. e217272 ◽  
Author(s):  
Umasankar Mathuram Thiyagarajan ◽  
Amirthavarshini Ponnuswamy ◽  
Alex Chung
Keyword(s):  
Acute Pancreatitis ◽  
Diabetic Ketoacidosis ◽  
Acute Abdomen ◽  
Causal Factor ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
The Real ◽  
Common Causes ◽  
Recent Diagnosis ◽  
The Common

Acute pancreatitis(AP) is one of the common causes of acute abdomen and known to be associated with high morbidity and mortality in severe cases. Though most common causes of AP are cholelithiasis and alcoholism, it has also been reported in association with diabetic ketoacidosis (DKA). Triad of AP, hypertriglyceridaemia (HTG) and DKA is rare co-association and here the causal factor of AP is still not fully established. We report a case of AP in a DKA patient with recent diagnosis of hyperlipidaemia and diabetes. Usually AP has been associated with severe HTG; interestingly, our patient showed only moderate raise in triglycerides but still suffered AP during DKA. Hence, it raises question about the real culprit in this enigmatic triad.

scholarly journals Prophylactic antibiotics in acute pancreatitis: endless debate

2017 ◽  
Vol 99 (2) ◽  
pp. 107-112 ◽  
Author(s):  
MM Mourad ◽  
RPT Evans ◽  
V Kalidindi ◽  
R Navaratnam ◽  
L Dvorkin ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ ◽  
Prophylactic Antibiotics ◽  
Morbidity And Mortality ◽  
Current Evidence ◽  
High Morbidity ◽  
Antibiotic Administration ◽  
Infected Necrosis ◽  
Pancreatic Infection

INTRODUCTION The development of pancreatic infection is associated with the development of a deteriorating disease with subsequent high morbidity and mortality. There is agreement that in mild pancreatitis there is no need to use antibiotics; in severe pancreatitis it would appear to be a logical choice to use antibiotics to prevent secondary pancreatic infection and decrease associated mortality. MATERIALS AND METHODS A non-systematic review of current evidence, meta-analyses and randomized controlled trials was conducted to assess the role of prophylactic antibiotics in acute pancreatitis and whether it might improve morbidity and mortality in pancreatitis. RESULTS Mixed evidence was found to support and refute the role of prophylactic antibiotics in acute pancreatitis. Most studies have failed to demonstrate much benefit from its routine use. Data from our unit suggested little benefit of their routine use, and showed that the mortality of those treated with antibiotics was significantly higher compared with those not treated with antibiotics (9% vs 0%, respectively, P = 0.043). In addition, the antibiotic group had significantly higher morbidity (36% vs 5%, respectively, P = 0.002). CONCLUSIONS Antibiotics should be used in patients who develop sepsis, infected necrosis-related systemic inflammatory response syndrome, multiple organ dysfunction syndrome or pancreatic and extra-pancreatic infection. Despite the many other factors that should be considered, prompt antibiotic therapy is recommended once inflammatory markers are raised, to prevent secondary pancreatic infection. Unfortunately, there remain many unanswered questions regarding the indications for antibiotic administration and the patients who benefit from antibiotic treatment in acute pancreatitis.

Su1464 HIGH MORBIDITY AND MORTALITY BURDEN OF ALCOHOL WITHDRAWAL IN ACUTE PANCREATITIS RELATED HOSPITALIZATIONS

2020 ◽  
Vol 158 (6) ◽  
pp. S-589
Author(s):  
Savan Kabaria ◽  
Lauren Pioppo ◽  
Augustine Tawadros ◽  
Debashis Reja ◽  
Anish V. Patel
Keyword(s):  
Acute Pancreatitis ◽  
Alcohol Withdrawal ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Mortality Burden

Management of oesophageal anastomosis dehiscence after oesophagectomy for oesophageal cancer

2020 ◽  
Vol 99 (5) ◽  
pp. 200-206
Keyword(s):  
Oesophageal Cancer ◽  
Surgical Procedure ◽  
Anastomotic Dehiscence ◽  
Gastric Conduit ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Therapeutic Algorithm

Oesophagectomy is being used in treatment of several oesophageal diseases, most commonly in treatment of oesophageal cancer. It is a major surgical procedure that may result in various complications. One of the most severe complications is anastomotic dehiscence between the gastric conduit and the oesophageal remnant. Anastomotic dehiscence after esophagectomy is directly linked to high morbidity and mortality. We propose a therapeutic algorithm of this complication based on published literature and our experience by retrospective evaluationof 164 patients who underwent oesophagectomy for oesophageal cancer. Anastomotic dehiscence was present in 29 cases.

scholarly journals Pneumocephalus Following Self-Inflicted Penetrating Brain Injury

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Che-Fang Ho ◽  
Yuan-Yun Tam ◽  
Chia-Chen Wu
Keyword(s):  
Rare Complication ◽  
Bed Rest ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Adequate Treatment ◽  
Cerebrospinal Fluid Rhinorrhea ◽  
Intravenous Antibiotics ◽  
Computed Tomography Scans ◽  
Intravenous Hydration ◽  
Prompt Diagnosis

Objective. Pneumocephalus is a rare complication that often occurs after traumatic skull base injury, leading to morbidity and mortality. Material and Method. We present the case of a 42-year-old healthy man who injured himself when he stuck a metal stick into his left nasal cavity to relieve prolonged nasal obstruction. Immediate cerebrospinal fluid rhinorrhea and subsequent meningitis and pneumocephalus occurred later. He was presented at our hospital with fever and meningeal signs. Result. Computed tomography scans revealed left rhinosinusitis and air collection in the subarachnoid space. The patient received the conservative treatment of bed rest, intravenous hydration, head elevation, and broad-spectrum intravenous antibiotics. Pneumocephalus and meningitis resolved without any surgery, and he experienced no other sequela or complication. Conclusion. Pneumocephalus is a rare incidence and can lead to high morbidity and mortality. Prompt diagnosis and adequate treatment of pneumocephalus and meningitis proved beneficial for our patient who recovered without any complication or surgery.

Sign in / Sign up

Export Citation Format

Share Document