Leigh syndrome, also referred to as Sub acute necrotising encephalopathy usually presents with symptoms like developmental delay, regression of
neurological skills and sudden death. Approximately 25% of the patients are abnormal at birth with features like hypotonia, lactic acidosis, feeding
problems, hypoglycemia, hyperbilirubinemia, cardiac complications, seizures and/or hyperammonemia. Here, we present 6 cases of Leigh's
disease , who presented within 6 months of life with neurological regression and hypotonia as the predominent manifestations with MRI ndings
showing Bilateral symmetrical hyperintensities in T2 weighted images which are characteristic ndings in Leigh's disease.