scholarly journals Glaucoma Progressing Stage Estimated from Visual Field Test Data with Glaucoma Patient; and Zinc(Ⅱ) Induced Regenerative Ativity from Optic Nerve Damage

2021 ◽  
pp. 1-7
Author(s):  
Tsuneo Ishida
Keyword(s):  
Optic Nerve ◽  
Visual Field ◽  
Axon Regeneration ◽  
Ganglion Cells ◽  
Glaucoma Patient ◽  
Nerve Damage ◽  
Mean Deviation ◽  
No Production ◽  
Coordination Pattern ◽  
Optic Nerve Damage

Glaucoma progressing stages (Stages 1～5) estimated from Visual Field Index (VFI); Mean Deviation (MD); and Pattern Standard Deviation (PSD) data has been elucidated; in which the glaucomatous pathology is in the proceeding stage 2-3 with T. Ishida's glaucoma patient compared with referring with VFI; MD; and PSD values to the literatures. Zinc(Ⅱ) induced VFI improvement should be taken into account when interpreting rates of VFI change over time that zinc promotes Retinal Ganglion Cells (RGCs) survival; in which zinc intake in RGCs survival may be zinc acetate 25-50 mg/day. Zinc(Ⅱ) induced recovery activity from optic nerve damage of the eye consists of four processes as follows. (1) Intraocular inflammatory stimulation process; Zinc concentrations 123-292 μg/g inhibit intraocular inflammation with atypical growth factor oncomodulin (Ocm) binding to its cognate receptor on RGCs. (2) RGC survival process; Zn2+ chelators enhance RGC survival and promote axon regeneration through the optic nerve. (3) Neural axon regeneration process; Zn2+ chelation promotes axon regeneration. Norepinephrine Transporters (Net) inhibitor promotes RGCs survival and axonal regeneration. (4) Eye to brain pathway process; Zn2+ chelator TPEN promotes both enduring RGC survival and considerable axon regeneration. Zinc induced recovery for NO production in RGCs that the NO conveys from the eye to the brain through the axons of RGCs; in which zinc concentration 100 μM may be suited for the optic nerve recovery. Accordingly; Zinc(Ⅱ) could enhance optic nerve damage recovery that Zn2+ may be bound with optic nerve damage proteins; in which Zn2+ ions may bind with intraocular protein; RGC survival protein; axonal protein; and optic nerve disorder proteins during recovery process by Zn2+ ions-centered tetrahedrally binding proteins molecular coordination pattern.

scholarly journals BAX-Depleted Retinal Ganglion Cells Survive and Become Quiescent Following Optic Nerve Damage

2019 ◽  
Vol 57 (2) ◽  
pp. 1070-1084 ◽  
Author(s):  
Ryan J. Donahue ◽  
Margaret E. Maes ◽  
Joshua A. Grosser ◽  
Robert W. Nickells
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Nerve Damage ◽  
Retinal Ganglion ◽  
Optic Nerve Damage

scholarly journals Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells

2016 ◽  
Vol 625 ◽  
pp. 11-15 ◽  
Author(s):  
Heather M. Schmitt ◽  
Cassandra L. Schlamp ◽  
Robert W. Nickells
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Nerve Damage ◽  
Retinal Ganglion ◽  
Optic Nerve Damage

Neurofilament light chain as biomarker in idiopathic intracranial hypertension

Cephalalgia ◽  
2020 ◽  
Vol 40 (12) ◽  
pp. 1346-1354
Author(s):  
Dagmar Beier ◽  
Johanne Juhl Korsbæk ◽  
Jonna Skov Madsen ◽  
Dorte Aalund Olsen ◽  
Laleh Dehghani Molander ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Optic Nerve ◽  
Visual Field ◽  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Nerve Damage ◽  
Visual Field Defects ◽  
Neurofilament Light Chain ◽  
Optic Nerve Damage ◽  
Field Defects

Background Damage of the optic nerve is the major complication of idiopathic intracranial hypertension. A biomarker indicative for optic nerve damage would help identifying high-risk patients requiring surgical procedures. Here, we studied the potential of cerebrospinal fluid neurofilament to predict idiopathic intracranial hypertension-induced optic nerve damage. Methods In two centers, serum and cerebrospinal fluid of 61 patients with clinically suspected idiopathic intracranial hypertension were prospectively collected. Neurofilament concentrations were measured and related to ophthalmological assessment. Results The average cerebrospinal fluid neurofilament concentration in patients with moderate and severe papilledema was increased compared to patients with minor and no papilledema (1755 ± 3507 pg/ml vs. 244 ± 102 pg/ml; p < 0.001). Cerebrospinal fluid neurofilament concentrations correlated with the maximal lumbar puncture opening pressure (r = 0.67, p < 0.001). In patients fulfilling the Friedman criteria for idiopathic intracranial hypertension with or without papilledema (n = 35), development of bilateral visual field defects and bilateral atrophy of the optic nerve were associated with increased average age-adjusted cerebrospinal fluid neurofilament concentrations. At last follow-up (n = 30), 8/13 of patients with increased, but only 3/17 with normal, cerebrospinal fluid neurofilament had developed bilateral visual field defects and/or bilateral optic nerve atrophy resulting in a sensitivity of 72.7% and a specificity of 73.7% of cerebrospinal fluid neurofilament to detect permanent optic nerve damage. Conclusions Cerebrospinal fluid neurofilament is a putative biomarker for optical nerve damage in idiopathic intracranial hypertension.

Optic Nerve Damage in Alzheimer's Disease

Ophthalmology ◽  
1990 ◽  
Vol 97 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Alfredo A. Sadun ◽  
Carl J. Bassi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Optic Nerve ◽  
Nerve Damage ◽  
Optic Nerve Damage

scholarly journals Taurine protects against retinal and optic nerve damage induced by endothelin-1 in rats via antioxidant effects

2018 ◽  
Vol 13 (11) ◽  
pp. 2014 ◽  
Author(s):  
Renu Agarwal ◽  
NatashaNajwa Nor Arfuzir ◽  
Igor Iezhitsa ◽  
Puneet Agarwal ◽  
Sabrilhakim Sidek ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Damage ◽  
Endothelin 1 ◽  
Optic Nerve Damage ◽  
Antioxidant Effects

scholarly journals A Case of Locally Invasive Fungal Sinusitis Resulting in Optic Nerve Damage

2012 ◽  
Vol 23 (2) ◽  
pp. 270-273
Author(s):  
Jung-Hoon Lee ◽  
Chan-Hwi Park ◽  
Kyu-Sup Cho ◽  
Hwan-Jung Roh
Keyword(s):  
Optic Nerve ◽  
Nerve Damage ◽  
Fungal Sinusitis ◽  
Optic Nerve Damage ◽  
Invasive Fungal Sinusitis
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