Choroidal Thickness and Structural Glaucoma Parameters in Glaucomatous, Preperimetric Glaucomatous, and Healthy Eyes using Swept-Source OCT

2017 ◽  
Vol 27 (5) ◽  
pp. 548-554 ◽  
Author(s):  
Handan Akil ◽  
Mayss Al-Sheikh ◽  
Khalil Ghasemi Falavarjani ◽  
Brian Francis ◽  
Vikas Chopra
Keyword(s):  
Nerve Fiber ◽  
Choroidal Thickness ◽  
Wide Field ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Swept Source ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
The Mean ◽  
Healthy Eyes

Purpose To evaluate choroidal thickness (CT) and its relationship with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer thickness (GCIPLT) in glaucomatous, preperimetric glaucomatous, and healthy eyes using swept-source optical coherence tomography (SS-OCT). Methods Fifty eyes with primary open-angle glaucoma, 20 eyes with preperimetric glaucoma, and 20 age-matched healthy eyes were enrolled. Three-dimensional wide-field (12 × 9 mm) images were obtained using a SS-OCT instrument. Peripapillary CT and RNFL thickness, as well as macular CT and GCIPLT, were recorded. The correlation of the CT with nerve fiber layer and GCIPLT measurements was assessed. The association between CT and potential confounding variables including age, sex, axial length, intraocular pressure, and central corneal thickness was also examined. Results Mean peripapillary CTs were 111.7 ± 41.7, 127.7 ± 40.1, and 120.8 ± 35.4 μm in glaucomatous, preperimetric glaucomatous, and normal eyes, respectively. There was statistically significant but weak correlation for the mean RNFL and mean peripapillary CT in glaucomatous subjects (r = 0.341, p = 0.04). There was a significant correlation between RNFL thickness and peripapillary CT in 1, 2, 5, and 6 clock hours of glaucomatous eyes (r = 0.410, p = 0.005; r = 0.316, p = 0.03; r = 0.346, p = 0.02; r = 0.35, p = 0.04, respectively). Mean macular CT was 181.5 ± 70.5, 187.4 ± 65.5, and 185.4 ± 76.4 μm in glaucomatous, preperimetric glaucomatous, and healthy eyes, respectively (p = 0.7). There was no statistically significant correlation between the mean GCIPLT and mean macular CT in all subjects (p>0.05). Conclusions Choroidal thinning and its correlation with other parameters in patients with glaucoma should be further investigated with the proprietary software of SS-OCT.

scholarly journals Choroidal thickness and retinal nerve fiber layer analysis in acute systemic brucellosis

2021 ◽  
Vol 19 ◽  
pp. 205873922110406
Author(s):  
Kürşad Ramazan Zor ◽  
Tuğba Arslan Gülen ◽  
Gamze Yıldırım Biçer ◽  
Erkut Küçük ◽  
Ayfer İmre ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Choroidal Thickness ◽  
Control Group ◽  
Fiber Layer ◽  
Subfoveal Choroidal Thickness ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
The Mean ◽  
Retinal Nerve Fiber

Introduction This study aims to detect changes in choroidal thickness and retinal nerve fiber layer (RNFL) thickness in acute stage brucellosis. Methods Fnewly diagnosed patients with acute brucellosis and 19 healthy individuals as control group were included in the study. Choroidal thickness and RNFL thickness were measured using the Spectral Domain Cirrus OCT Model 400 (Carl Zeiss Meditec, Jena, Germany) for each participant in the patient and control group. Results In the brucella group, in the right eyes, the mean nasal choroidal thickness was 272.77 ± 50.26 μm ( p = 0.689), the mean subfoveal choroidal thickness was 321.14 ± 33.08 μm ( p = 0.590), the mean temporal choroidal thickness was 278.86 ± 48.84 μm ( p = 0.478), and the mean RNFL thickness was 90.43 ± 8.93 μm ( p = 0.567). In the left eyes, the mean nasal choroidal thickness was 282.29 ± 48.93 μm ( p = 0.715), the mean subfoveal choroidal thickness was 316.79 ± 39.57 μm ( p = 0.540), the mean temporal choroidal thickness was 284.93 ± 50.57 μm ( p = 0.392), and the mean RNFL thickness was 92.64 ± 8.95 μm ( p = 0.813). Conclusion No difference was found between the control and the brucella groups regarding to all choroidal regions and RNFL thickness.

Comparative Analysis of Retinal Nerve Fiber Layer Thickness between Normal and Mild to Moderately Myopic Eyes

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Gul Nasreen ◽  
Shaheer Suhail Sarwar ◽  
Irfana Bibi ◽  
Muhammad Arslan Ashraf
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Rnfl Thickness ◽  
The Mean ◽  
Retinal Nerve Fiber

Purpose:  To determine the difference between mean retinal nerve fiber layer (RNFL) thickness in myopic eyes (up to -6.00D) and normal eyes. Study Design:  Descriptive observational study. Place and Duration of the Study:  Eye department of Mayo hospital Lahore, from February 2019 to April 2019. Methods:  We compared the mean RNFL between 58 myopic eyes (up to -6.00 D) and age matched 60 normal eyes. The age of the participants was between 12 to 42 years. Complete ocular examination was done and RNFL thickness was measured by using Optical coherence tomography (NIDEX RS-33.0, software-ex 1.5.2).Data was analyzed by independent sample t-test by using SPSS; with P < .05 as significant. Results:  The mean difference among these groups was 5.852 µm with (SE: 1.929). Mean RNFL thickness in myopic group was (95.93 ± 10.158µm) with (SE: 1.334). The result for mean RNFL thickness in myopic eyes was distributed normally as P < .03. Mean RNFL in normal group was (101.78 ± 10.774 µm) with (SE: 1.391), and the result of mean RNFL thickness measured in normal eyes was not distributed normally as P < .20. The results showed that there is a statistically significant difference between mean RNFL thickness measured in normal versus myopic eyes as (P < .003). Conclusion:  There is a significance difference between mean RNFL thickness between myopic eyes and normal eyes as measured by OCT. Careful interpretation of RNFL data in myopic eyes is recommended to avoid misdiagnosis with glaucoma. Key Words:  Retinal Nerve Fiber Layer thickness, Myopia, Optical Coherence Tomography.

Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis

2008 ◽  
Vol 14 (5) ◽  
pp. 609-614 ◽  
Author(s):  
V Pueyo ◽  
J Martin ◽  
J Fernandez ◽  
C Almarcegui ◽  
J Ara ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Axonal Loss ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Healthy Eyes ◽  
Retinal Nerve Fiber

Objective To quantify axonal loss in the retinal nerve fiber layer (RNFL) in patients with multiple sclerosis (MS), with and without a history of optic neuritis, by means of ocular imaging technologies. Methods This cross-sectional study enrolled 50 patients with MS and 25 age- and sex-matched healthy controls. All patients underwent neurologic assessment and a complete ophthalmic examination that included visual acuity, visual field examination, optical coherence tomography (OCT), scanning laser polarimetry (GDx) and visual evoked potentials (VEPs). Visual parameters and RNFL measurements were evaluated in MS eyes with a prior optic neuritis episode (MS-ON), with no prior episode (MS-NON) and control subjects. Results There were significant differences ( p < 0.05, analysis of variance) between MS-ON ( n = 25 eyes) and healthy eyes ( n = 25 eyes) for all RNFL parameters measured by OCT and GDx. Significant differences between MS-NON ( n = 75 eyes) and healthy eyes were also found for most of these parameters. RNFL thickness in the temporal quadrant was the parameter with the greatest differences between groups (71.79 μm in healthy eyes, 60.29 μm in MS-NON and 53.92 μm in MS-ON, p < 0.0005). Although there was a highly significant but moderate correlation between RNFL thickness and duration of the disease, no correlation was observed between RNFL thickness and neurologic impairment (Expanded Disability Status Scale). Conclusions Axonal loss was detected not only in MS eyes with a previous acute optic neuritis, but also in MS eyes with no known optic neuritis episode. Structural abnormalities correlate with functional assessments of the optic nerve.

scholarly journals The Effect of LASIK Procedure on Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Eyes

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Maja Zivkovic ◽  
Vesna Jaksic ◽  
Athanassios Giarmoukakis ◽  
Michael Grentzelos ◽  
Marko Zlatanovic ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Significant Difference ◽  
Retinal Nerve Fiber

Purpose. To evaluate the effect of applied suction during microkeratome-assisted laser in situ keratomileusis (LASIK) procedure on peripapillary retinal nerve fiber layer (RNFL) thickness as well as macular ganglion cell-inner plexiform layer (GC-IPL) thickness. Methods. 89 patients (124 eyes) with established myopia range from −3.0 to −8.0 diopters and no associated ocular diseases were included in this study. RNFL and GC-IPL thickness measurements were performed by spectral domain optical coherence tomography (SD OCT) one day before LASIK and at 1 and 6 months postoperatively. Results. Mean RNFL thickness prior to LASIK was 93.86±12.17 μm while the first month and the sixth month postoperatively were 94.01±12.04 μm and 94.46±12.27 μm, respectively. Comparing results, there is no significant difference between baseline, one month, and six months postoperatively for mean RNFL (p>0.05). Mean GC-IPL thickness was 81.70±7.47 μm preoperatively with no significant difference during the follow-up period (82.03±7.69 μm versus 81.84±7.64 μm; p>0.05). Conclusion. RNFL and GC-IPL complex thickness remained unaffected following LASIK intervention.

scholarly journals To evaluate the retinal nerve fiber layer thickness in different types of glaucoma

2021 ◽  
Vol 11 (1) ◽  
pp. 5-9
Author(s):  
Aqsa Batool ◽  
Iqra Nehal ◽  
Areej Riaz ◽  
Muzna Javed ◽  
Tahir Hussain ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Physical Damage ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Rnfl Thickness ◽  
The Mean ◽  
Retinal Nerve Fiber

Objective: Glaucoma is a multifaceted eye disease which is classified as physical damage of retinal ganglion cells which may effect in loss of vision and permanent blindness. While physical damage of glaucoma can be clinically evaluated the optic nerve head and peripapillary retinal nerve fiber layer (RNFL). Our objective is to evaluate the mean RNFL thickness in all types of glaucoma. Methodology: This prospective and cross sectional study was conducted in Glaucoma Clinic of Al Ibrahim Eye Hospital (AIEH), Karachi, for the period from May 2019 to October 2019, after ethical approval from Institutional Research Committee. A total of 64 glaucoma patients were chosen by using non-probability purposive sampling technique. The participant comprised, no known eye disease, no visual impairment, IOP below 22 mmHg, and no obvious retinal disease or defect were included while individuals having a history of ocular diseases or pathology with residual visual impairment, retinal diseases, amblyopia, and history of intraocular surgery or laser therapy were excluded from the study. The collected data were analyzed using Statistical Package for Social Sciences (SPSS) version 20. Results: 64 patients of both genders with mean age of 55.54±15.58 years. The mean intraocular pressure of right eye and left eye was 16.46±8.06 and 16.75±7.82 mmHg, respectively. The mean RNFL thickness in superior, inferior, temporal and nasal quadrant of the right eye was measured 68.23±25.44, 66.79±27.50, 51.75±12.58 and 47.73±18.82 microns, respectively while the mean RNFL thickness in superior, inferior, temporal and nasal quadrant of the left eye was measured 76.01±22.72, 67.42±21.25, 54.37±13.0 and 49.62±11.57 microns, respectively. Conclusion: Our study showed that analysis of retinal nerve fiber layer thickness with optical coherence tomography is the best tool for the diagnosis of glaucoma. It has also been observed in our study that frequency of changes in retinal nerve fiber layer thickness was mostly found in primary open angle glaucoma patients

scholarly journals Retinal Nerve Fibre Layer Analysis in Non-Glaucomatous Pseudoexfoliation Syndrome Patients

2021 ◽  
Author(s):  
Erum Waris Khateeb ◽  
Imtiyaz Ahmad Lone ◽  
Ifrah Ahmad Qazi
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Pseudoexfoliation Syndrome ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Retinal Nerve Fiber

Abstract Background Pseudoexfoliation syndrome (PXS) is a disorder characterized by the progressive accumulation of fibrillary extracellular deposits in several ocular tissues. It is an independent risk factor for glaucomatous optic nerve damage. Retinal nerve fiber layer (RNFL) thickness analysis using optical coherence tomography is a documented investigative tool to detect glaucoma at an early stage. Objective The aim was to evaluate and compare RNFL thickness in PXS patients without glaucoma with their age- and sex-matched healthy controls and detect the possibility of early glaucomatous damage in patients with RNFL thinning. Study Design This was a cross sectional case–control study. Materials and Methods A total of 100 patients were included, of which 50 were cases (Group A) and 50 were controls (Group B). RNFL thickness of cases and controls were compared using Zeiss Cirrus HD-OCT 500 (ZEISS Medical Technology, United States). Results There were no significant differences between the two groups with respect to mean RFNL thickness in nasal (p = 0.129) and temporal quadrants (p = 0.832). The mean inferior RNFL thickness values were 112.9 ± 21.72 μm in Group A and 120.6 ± 10.35 μm in Group B (p = 0.002). The mean thickness of the retinal nerve fiber layer in superior quadrant in Group A was 101.6 ± 23.16 μm, whereas it was 113.5 ± 13.47 μm in group B (p < 0.001). The average RFNL thickness in Group A was 85.1 ± 13.99 μm and it was 88.9 ± 7.01 μm in Group B (p = 0.017). Conclusion There was statistically significant difference in RNFL thickness between cases and controls in inferior and superior quadrants and in global average thickness.

Effects of Panretinal Laser Photocoagulation on the Corneal Nerve Plexus and Retinal Nerve Fiber Layer in Retinal Vein Occlusion

2017 ◽  
Vol 27 (5) ◽  
pp. 591-595 ◽  
Author(s):  
Gulfidan Bitirgen ◽  
Selman Belviranli ◽  
Rayaz A. Malik ◽  
Hurkan Kerimoglu ◽  
Ahmet Ozkagnici
Keyword(s):  
Nerve Fiber ◽  
Retinal Vein Occlusion ◽  
Retinal Nerve Fiber Layer ◽  
Nerve Plexus ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Vein Occlusion ◽  
Rnfl Thickness ◽  
The Mean ◽  
Fellow Eyes

Purpose To determine the effects of panretinal photocoagulation (PRP) on corneal sub-basal nerve plexus (SBNP) and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with unilateral central retinal vein occlusion (CRVO) who had previously undergone PRP treatment. Methods Sixty-four eyes of 32 patients (19 male, 13 female) with unilateral ischemic type CRVO who had undergone PRP treatment at least 6 months previously were included in this cross-sectional study. The laser scanning in vivo corneal confocal microscope was used to determine corneal SBNP parameters. The peripapillary RNFL thickness was assessed with spectral-domain optical coherence tomography. Data obtained from the PRP-treated eyes were compared with those of the fellow unaffected eyes. Results The mean age of patients was 63.5 ± 10.7 years (range 45-85 years). The mean nerve fiber density (NFD), nerve branch density, and nerve fiber length (NFL) were significantly lower in PRP-treated eyes compared with fellow eyes (p<0.001 for all). Average peripapillary RNFL thickness was significantly lower in PRP-treated eyes than in fellow eyes (p = 0.007). The NFD and NFL showed a modest but significant positive correlation with average peripapillary RNFL thickness (r = 0.310, p = 0.013 and r = 0.272, p = 0.030, respectively). Conclusions Significant reductions in corneal SBNP parameters and average peripapillary RNFL thickness were observed in the eyes of patients receiving PRP for the treatment of ischemic CRVO.

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