The Effect of a Hydrocolloid Dressing on Second Intention Wound Healing in Cats

2018 ◽  
Vol 54 (3) ◽  
pp. 125-131 ◽  
Author(s):  
Vassiliki Tsioli ◽  
Pagona G. Gouletsou ◽  
Apostolos D. Galatos ◽  
Dimitra Psalla ◽  
Antonios Lymperis ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Evaluation ◽  
The Other ◽  
Skin Wounds ◽  
Tissue Formation ◽  
Dorsal Midline ◽  
Granulation Tissue Formation ◽  
Hydrocolloid Dressing ◽  
Thickness Skin ◽  
The Right

ABSTRACT The objective of the present study was to evaluate the effect of a hydrocolloid dressing on second intention wound healing in cats. Two full-thickness skin wounds, measuring 2 × 2 cm, were created on both sides of the dorsal midline of 10 cats; bilaterally, one randomly selected wound was bandaged with a hydrocolloid dressing and the second one (control) with a semiocclusive pad. Subjective clinical evaluation of granulation tissue formation, of the quantity and nature of wound exudate, and planimetry were performed on the right-side wounds, and histological examination on the left. No significant differences in subjective clinical evaluation or in planimetry were observed between the hydrocolloid-treated wounds and controls. Most wounds had serous or absence of exudate (41.25% and 25%, respectively), whereas purulent exudate was observed in 7.5% of wounds. Edema was significantly increased in the hydrocolloid-treated wounds compared with controls on day 7 but no significant differences in the other histological variables were observed.

Effects of two occlusive, hydrocolloid dressings on healing of full-thickness skin wounds in cats

2016 ◽  
Vol 29 (04) ◽  
pp. 298-305
Author(s):  
Pagona Gouletsou ◽  
Apostolos Galatos ◽  
Dimitra Psalla ◽  
Antonis Lymperis ◽  
Lyssimachos Papazoglou ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Healing ◽  
Bacterial Growth ◽  
Granulation Tissue ◽  
Subjective Evaluation ◽  
Skin Wounds ◽  
Tissue Formation ◽  
Full Thickness ◽  
Granulation Tissue Formation ◽  
Thickness Skin

Summary Objectives: To determine the effects of two occlusive, hydrocolloid dressings on second intention wound healing in cats. Methods: Three 2×2 cm full-thickness skin wounds were created on each side of the trunk of 10 cats. Two bilateral wounds were bandaged using different hydrocolloid dressings, namely Hydrocoll and DuoDerm while a semi-occlusive pad (Melolin) was applied to the third bilateral wound (control group). Wound planimetry, subjective evaluation of wound healing, and qualitative bacterial cultures were performed on the right-sided wounds, whereas left-sided wounds were subjected to histological examination. Results: Subjective evaluation revealed accelerated (p <0.01) granulation tissue formation in hydrocolloid-treated wounds. The amount of wound exudate was initially greater (p <0.01) in these wounds. Seventeen out of 120 evaluated wounds (14.2%) produced purulent exudate, 11 of which showed Staphylococcus aureus growth. Fewer control wounds (3/17) emitted puru-lent exudate, but all of them yielded moderate bacterial growth as compared to hydrocolloid-treated wounds (8/17) which had a low incidence of bacterial growth. The only significant difference in histological variables was increased cellular infiltration noted on day 7 in Hydrocoll-treated wounds compared to controls. No significant differences in planimetry variables were found between groups. Clinical significance: Despite the initially increased amount of wound exudate and the low growth of Staphylococcus aureus, hydrocolloid dressings accelerate granulation tissue formation and can hence be suggested for second intention wound healing in cats.

Naturally Occurring Isohexenylnaphthazarins and Wound Healing: Experimental Study in Dogs

2010 ◽  
Vol 14 (2) ◽  
pp. 62-70 ◽  
Author(s):  
Maria Karayannopoulou ◽  
Panagiotis Loukopoulos ◽  
Lysimachos G. Papazoglou ◽  
Vassiliki Tsioli ◽  
Tilemahos L. Anagnostou ◽  
...  
Keyword(s):  
Wound Healing ◽  
Subjective Evaluation ◽  
Tissue Perfusion ◽  
Petroleum Jelly ◽  
Dorsal Midline ◽  
Doppler Flowmetry ◽  
Naturally Occurring ◽  
Thickness Skin ◽  
Histologic Evaluation ◽  
The Right

Background: The healing efficacy of isohexenylnaphthazarins (IHN) has been well proved on chronic or contaminated wounds. Objective: To evaluate the wound healing activity of an experimental ointment containing IHN on acute and noncontaminated wounds in dogs. Methods: In each of six beagle dogs, four full-thickness skin defects were created bilaterally: one 2 × 2 cm defect on the lateral aspect of each arm for subjective evaluation, laser Doppler flowmetry (LDF), and planimetry and three 1.5 × 1.5 cm defects on opposite sides of the dorsal midline for histologic evaluation. Wounds on the left were treated with an ointment based on IHN and on the right with another based on petroleum jelly (Vaseline) and beeswax. Results: Wound size decreased significantly in both sides. The significantly increased percentage of epithelialization was higher ( p = .0274) in the petroleum jelly–treated wounds on day 20. Tissue perfusion (LDF) increased significantly bilaterally in the center of the wound but only in the IHN-treated side cranial to the wound. Histologically, angiogenesis was significantly higher ( p = .0431) on day 5 in the IHN-treated wounds compared with the petroleum jelly–treated wounds. Collagen production increased significantly bilaterally. Conclusion: The IHN-based ointment promoted some of the proliferative processes, but it did not enhance the overall wound healing of acute, surgically created wounds in dogs.

scholarly journals Combined carbon photon and hydrogel therapy mediates the synergistic repair of full-thickness skin wounds

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052093532
Author(s):  
Fan Yang ◽  
Xiuling Zhou ◽  
Sitong Chen ◽  
Qiuju Li ◽  
Ronghang Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Light Exposure ◽  
Tissue Formation ◽  
Full Thickness ◽  
Granulation Tissue Formation ◽  
Treatment Groups ◽  
Wound Model ◽  
Thickness Skin ◽  
Treatment Of Wounds ◽  
Photon Exposure

Objective This study investigated the synergistic repair effects of Prontosan hydrogel and carbon photon therapy in a rat full-thickness wound model. Methods The wavelength distribution of the photon source was determined. Dehydration of the Prontosan hydrogel and fibroblast viability were analyzed following exposure to different durations of light exposure at different distances from the source. Indexes of wound healing in a full-thickness rat wound model were then determined in groups ( n = 8 each) subjected to either no treatment, Prontosan treatment only, carbon photon therapy only, or a combination of the two treatments (synergistic group). Results Carbon photon exposure for 15 minutes at a distance of 20 cm from the wound was found to be optimal. Wound healing occurred faster in the synergistic group compared with the control and single-treatment groups. Growth factor secretion, granulation tissue formation, inflammation regulation, collagen deposition, and neovascularization were all higher in the synergistic group. Conclusions Prontosan hydrogel combined with carbon photon therapy may provide an optimal environment for wound healing and serve as a novel physical approach to the treatment of wounds. However, the number of animals included in this study was relatively small and a larger study is required to confirm these findings.

Shiunko and Acetylshikonin Promote Reepithelialization, Angiogenesis, and Granulation Tissue Formation in Wounded Skin

2008 ◽  
Vol 36 (01) ◽  
pp. 115-123 ◽  
Author(s):  
Pao-Ju Lu ◽  
Cheng Yang ◽  
Ching-Nan Lin ◽  
Chien-Feng Li ◽  
Chin-Chen Chu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Histological Study ◽  
Silver Sulfadiazine ◽  
The Other ◽  
Tissue Formation ◽  
Sprague Dawley ◽  
Granulation Tissue Formation ◽  
Sprague Dawley Rats ◽  
Infected Wounds

Shiunko is a traditional botanic formula (ointment) used clinically for treating wounded skin. The aim of the present study was to compare the effects of Shiunko and acetylshikonin, and its active ingredient, with those of gentamicin and silver sulfadiazine ointments, two disinfectants for wound healing. Wounds were cut in the backs of Sprague-Dawley rats. Different bacterial inoculations (Pseudomonas aeruginosa and Staphylococcus aureus) and treatments (Shiunko, acetylshikonin, gentamicin, silver sulfadiazine, and vehicle ointments) were used to treat these wounds. We found that rats treated with Shiunko and acetylshikonin on both the sterilized and infected wounds showed higher rates of reepithelialization than those treated with the other ointments (p < 0.05) during a 7-day observation. In the histological study, rats treated with Shiunko and acetylshikonin on both the sterilized and infected wounds showed greater reepithelialization, angiogenesis, and granulation tissue formation than rats treated with the other ointments (p < 0.05) on day 5 after the wounds had been sutured. Differences between rats treated with Shiunko and acetylshikonin ointments were not statistically significant. In conclusion, topically applying Shiunko and acetylshikonin on wounded skin promoted wound healing. Both ointments were effective on sterilized and infected wounds.

scholarly journals Effectivity of topical mangosteen pericarp extract cream on wound healing in Swiss albino mice

2019 ◽  
Vol 92 (2) ◽  
Author(s):  
Hilda Brigitta Sombolayuk ◽  
Khairuddin Djawad ◽  
Siswanto Wahab ◽  
Upik A. Miskad ◽  
Gemini Alam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Inflammatory Cells ◽  
Control Group ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Swiss Albino Mice ◽  
Accelerate Wound Healing ◽  
Acute Wound ◽  
Albino Mice

Wound healing is a complex physiological process consisting of four phases: coagulation, inflammation, proliferation and migration, and remodeling, each with distinct characteristics. Studies have suggested that mangosteen pericarp extract (MPE) may accelerate wound healing. However, the mechanism has not been fully understood. This study aims to evaluate the effect of MPE cream in various concentrations in acute wound healing of albino mice, both histologically and macroscopically. Thirty-two healthy female Swiss albino mice, aged 6-9 weeks, weight 20-30 g, were included in this study. The samples were randomly divided into eight groups each consisting of 4 mice. The first four groups were treated with MPE cream 5%, 10%, and 20%, and no medication (control group), respectively, and were sacrificed after three days. The other four groups received the same application and were sacrificed after 8 days. Wound bed diameter was measured and biopsy from the skin lesion was performed for histopathologic examination. Mann-Whitney test was used to analyze the diameter of the wound bed and histopathological findings of granulation tissue formation, reepithelialization, and inflammation, with P<0.05 considered as significant. MPE cream significantly improved wound healing by increasing granulation tissue formation, and reepithelialization. In addition, MPE cream application was also shown to decrease the number of inflammatory cells, particularly in 5% and 10% concentrations, both in the 3-day and 8-day groups. MPE cream application can accelerate wound healing and thus can be used in acute wound treatment.

Biomimetic thermoplastic polyurethane porous membrane with hierarchical structure accelerates wound healing by enhancing granulation tissue formation and angiogenesis

RSC Advances ◽  
2016 ◽  
Vol 6 (101) ◽  
pp. 99595-99603 ◽  
Author(s):  
Qiang Lei ◽  
Zhichao Li ◽  
Rui Xu ◽  
Yuzhen Wang ◽  
Haisheng Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hierarchical Structure ◽  
Granulation Tissue ◽  
Wound Dressing ◽  
Thermoplastic Polyurethane ◽  
Porous Membrane ◽  
Tissue Formation ◽  
Granulation Tissue Formation

Wound dressing with hierarchical structure enhances wound healing.

Effects of Nanofiber/Stem Cell Composite on Wound Healing in Acute Full-Thickness Skin Wounds

2011 ◽  
Vol 17 (9-10) ◽  
pp. 1413-1424 ◽  
Author(s):  
Kun Ma ◽  
Susan Liao ◽  
Liumin He ◽  
Jia Lu ◽  
Seeram Ramakrishna ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Skin Wounds ◽  
Full Thickness ◽  
Full Thickness Skin ◽  
Thickness Skin
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