Verapamil, a Calcium-Channel Blocker, Improves the Wound Healing Process in Rats with Excisional Full-Thickness Skin Wounds Based on Stereological Parameters

2016 ◽  
Vol 29 (8) ◽  
pp. 371-374 ◽  
Author(s):  
Soheil Ashkani-Esfahani ◽  
Omid Koohi Hosseinabadi ◽  
Parinaz Moezzi ◽  
Yalda Moafpourian ◽  
Sina Kardeh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Healing Process ◽  
Wound Healing Process ◽  
Skin Wounds ◽  
Full Thickness ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals THE DYNAMICS OF WOUND HEALING IN THE TREATMENT WITH THE OINTMENT WITH A DRY EXTRACT OF POTENTILLA

2018 ◽  
Vol 25 (6) ◽  
pp. 105-109
Author(s):  
L. P. Lezhnevа ◽  
A. M. Temirbulatova ◽  
E. F. Stepanova ◽  
D. V. Veselova
Keyword(s):  
Wound Healing ◽  
Dosage Form ◽  
Healing Process ◽  
Control Group ◽  
Wound Healing Process ◽  
Skin Wounds ◽  
Full Thickness ◽  
Dry Extract ◽  
Full Thickness Skin ◽  
Thickness Skin

Aim. The study was designed for the evaluation of the effect of ointments with dry extracts of potentilla on the dynamics of the healing process of full-thickness skin wounds.Materials and methods. The wound healing activity estimation of the proposed dosage form was conducted on white Wistar rats. The results of macroscopic studies (the area of the wound defect, the state of the scab, the presence of hemorrhage beneath it, the degree of inflammatory processes in the underlying tissues, including deeply located tissue structures, up to the muscle elements) and the results of histological examination were the criterion for evaluating the effectiveness of the wound healing agent. In the course of the experiment, the animals were divided into 4 groups: the main group (treatment with the ointment with a dry extract of potentilla), control group No. 1 (treatment with the ointment base), control group No. 2 (without treatment), and control group No. 3 (treatment with the «Chlorophyllipt» drug.Results. The results of the macroscopic and histological studies made it possible to conclude that the wound healing process in the treatment with the ointment with a dry extract of potentilla had a number of features. The proposed dosage form enhanced the regeneration of the multilayered squamous epithelium, accelerated the maturation of the granulation tissue, and eliminated the inflammation and infiltration in the first days of treatment, which led to a significant reduction in the healing time when it was applied (15-18 days). In the animals of the control groups No. 1 and No. 2, the described processes occurred much more slowly, and inflammatory infiltration persisted almost throughout the entire experiment. The wound surface was healed on the 27-30th day. A lot of common features were noted in the mechanism and timing of wound healing in the treatment with the ointment with a dry extract of potentilla and a reference preparation – «Сhlorophyllipt». Conclusion. The ointment with a dry extract of potentilla significantly speeds up the healing process of full-thickness skin wounds.

scholarly journals The Effectivity of Ozonated VCO on Healing Full Grafted Skin graft Study on Progenitor Cell Endothelial Proliferation and Angiogenesis in Sprague Dawley Mice

2021 ◽  
Vol 8 (2) ◽  
pp. 133-138
Author(s):  
Rollin Hansen Sidauruk ◽  
Renny Yuniati ◽  
Djoko Handojo
Keyword(s):  
Wound Healing ◽  
Skin Graft ◽  
Healing Process ◽  
Wound Healing Process ◽  
Full Thickness ◽  
Sprague Dawley ◽  
Full Thickness Skin Graft ◽  
Accelerate Wound Healing ◽  
Full Thickness Skin ◽  
Thickness Skin

Abstract   Background : Full thickness  Skin graft is one technique to accelerate wound healing. EPC proliferation and new blood vessel formation have an important role in the success of Ful thickness  Skin graft. Ozone content in Ozonated VCO  has the ability to increase growth factors so that it can accelerate wound healing   Aims : This study was aimed to prove the effects of ozonated vco  in various doses in increasing EPC proliferation and angiogenesis in full thickness skin graft wounds.   Methods : This research is an experimental study with randomized post test only with parallel group design. 40 Sprague Dawley rats performed autologous  Skin grafts at the same time. Samples were randomly divided into 8 groups, two control groups (X1 and X5), and 6 other groups were given a multi-dose ozonated oil  50.6 mg / ml (X2, X6), 101.3 mg / ml (X3, X7) , 202.6 mg / ml (X4, X8). Conduct termination on day 6 and day 12. Examination of the number of  EPC proliferation and the number of angiogenesis in each group. Data were analyzed by Saphiro Wijk, ANOVA, post hoc benferonni and pearsons   Results : The number of EPC proliferation in groups X1, X2, X3, X4, X5, X6, X7, X8 has a mean of 6.2 + 0.837, 10 + 1.581, 13.80 + 2.049, 14.80+ 2,280, 9.40 + 2,074 , 13.20 + 1,483, 19,0 + 2,055 and 19.20 + 1,095.The number of Angiogenesis in groups X5, X6, X7, X8 has a mean of 9.20 + 1,095,14,60 + 2,881,17,40+ 3,286, 18,80 + 2,168,17,40 + 3,286,18.80+ 2,168. The administration of ozonated VCO  dose of 202.6 mg / ml gave the best results in the amount of angiogenesis (p = 0.001) and the amount of angiogenesis (p=0,001).Correlation analysis between EPC proliferation and angiogenesis showed a significant correlation (p = 0.001 and r = 0.738).   Conclusion : Ozonated oil can increase the number of EPC proliferation and angiogenesis in the wound healng process of Full thickness  Skin graft. The ozone dose of 202,6 mg / ml showed the best effect on increase wound healing process. Keyword : Full thickness skin graft, Ozonated oil , EPC, Angiogenesis  

Effects of Nanofiber/Stem Cell Composite on Wound Healing in Acute Full-Thickness Skin Wounds

2011 ◽  
Vol 17 (9-10) ◽  
pp. 1413-1424 ◽  
Author(s):  
Kun Ma ◽  
Susan Liao ◽  
Liumin He ◽  
Jia Lu ◽  
Seeram Ramakrishna ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Skin Wounds ◽  
Full Thickness ◽  
Full Thickness Skin ◽  
Thickness Skin

A cold plasma jet accelerates wound healing in a murine model of full-thickness skin wounds

2017 ◽  
Vol 26 (2) ◽  
pp. 156-162 ◽  
Author(s):  
Anke Schmidt ◽  
Sander Bekeschus ◽  
Kristian Wende ◽  
Brigitte Vollmar ◽  
Thomas von Woedtke
Keyword(s):  
Wound Healing ◽  
Murine Model ◽  
Cold Plasma ◽  
Plasma Jet ◽  
Skin Wounds ◽  
Full Thickness ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Acceleration of wound healing in acute full-thickness skin wounds using a collagen-binding peptide with an affinity for MSCs

2014 ◽  
Vol 2 (4) ◽  
pp. 181 ◽  
Author(s):  
Jianwu Dai ◽  
Qian Tan ◽  
Xin Yan ◽  
Yun Yang ◽  
Huili Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Wounds ◽  
Full Thickness ◽  
Collagen Binding ◽  
Binding Peptide ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Wound healing in immunocompromised dogs: A comparison between the healing effects of moist exposed burn ointment and honey

2020 ◽  
Vol 13 (12) ◽  
pp. 2793-2797
Author(s):  
Musa Alshehabat ◽  
Wael Hananeh ◽  
Zuhair Bani Ismail ◽  
Safwan Abu Rmilah ◽  
Mahmoud Abu Abeeleh
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Analysis Data ◽  
Punch Biopsy ◽  
Histopathological Analysis ◽  
Full Thickness ◽  
Imaging Data ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Skin Punch Biopsy

Background and Aim: Natural topical products have been used to enhance wound healing, especially in immunocompromised animals. The aims of this study were to evaluate and to compare the effects of moist exposed burn ointment (MEBO) and honey on the healing of full-thickness skin wounds in immunocompromised dogs. Materials and Methods: The study was conducted using 12 adults, apparently healthy mongrel dogs. Immunosuppression was induced in six dogs by oral administration of prednisone (2 mg/kg) and azathioprine (2 mg/kg), once a day for 21 days. On each dog, a total of 9, 1.5 cm in diameter full-thickness skin circular wounds were created aseptically in the thoracolumbar area under general anesthesia using customized skin punch biopsy kit. In a random fashion, three wounds in each dog were treatment using MEBO (contains b-sitosterol, baicalin, and berberine as active ingredients in a base of beeswax and sesame oil), honey or no treatment (control), once per day for 21 days. Wounds were grossly evaluated once a day for signs of inflammation or infection. In addition, biopsy specimens and digital imaging data of each wound were obtained on days 7, 14, and 21 for histopathological evaluation of the healing process. Results: Wounds in immunocompromised dogs appeared to heal significantly in a slower fashion than in non-immunocompromised counterparts. Digital analysis data showed that MEBO-treated wounds expressed better epithelialization area, faster contraction, and smaller wound area percentage when compared with honey-treated wounds. Histopathological analysis showed significantly higher angiogenesis scores in MEBO-treated wounds when compared with other treatments. Conclusion: Results of this study showed that MEBO resulted in significant enhancement of wound healing in both healthy and immunocompromised dogs. However, when compared to honey, the wound healing effect of MEBO was superior to that of honey.

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