A Niclosamide-releasing hot-melt extruded catheter prevents Staphylococcus aureus experimental biomaterial-associated infection

Biomaterial-associated infections are a major healthcare challenge as they are responsible for high disease burden in critically ill patients. In this study, we have developed drug-eluting antibacterial catheters to prevent catheter-related infections. Niclosamide (NIC), originally a well-studied antiparasitic drug, was incorporated into the polymeric matrix of thermoplastic polyurethane (TPU) via solvent casting, and catheters were fabricated using hot-melt extrusion technology. The mechanical and physicochemical properties of TPU polymers loaded with NIC were studied. NIC was released in a sustained manner from the catheters and exhibited antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis in different in vitro models. Moreover, the antibacterial efficacy of NIC-loaded catheters was validated in an in vivo biomaterial-associated infection mouse model using a methicillin-susceptible and methicillin-resistant strain of S. aureus. The released NIC from the produced catheters reduced bacterial colonization of the catheter as well as of the surrounding tissue. A sustained in vivo release of NIC from the catheters for at least 14 days was observed. In summary, the NIC-releasing hot-melt extruded catheters prevented implant colonization and reduced the bacterial colonization of peri-catheter tissue by methicillin sensitive as well as resistant S. aureus in a biomaterial-associated infection mouse model and has good prospects for preclinical development.

Flexible carbonized cotton/thermoplastic polyurethane composites with outstanding electric heating and pressure sensing performance

Although flexible wearable conductive textiles for various applications have attracted great attention from researchers in recent years, it is still a great challenge to fabricate conductive textiles with the advantages of a simple fabrication process, excellent flexibility, environmental friendliness, and superior performance. Carbonized cellulose materials are gradually emerging in flexible electronics due to their flexibility, low cost, abundant raw materials, and electrical conductivity. Herein, carbonized cotton fabrics were fabricated from cotton fabrics via a simple carbonization process. Then carbonized cotton/thermoplastic polyurethane composites, with excellent electric heating performance and pressure sensing performance, were fabricated through a dip-and-dry method. Carbonized cotton/thermoplastic polyurethane composites show satisfactory electrical conductivity, electric heating temperature rising performance, heating stability, and resistance stability. The surface temperature of carbonized cotton/thermoplastic polyurethane composites can reach ≈53°C within 1.5 min at 5 V. Besides this, the fabricated flexible pressure sensor based on carbonized cotton/thermoplastic polyurethane composites exhibits the combined superiority of a wide working range (0–16 kPa), high sensitivity (98.77 kPa−1), and excellent durability (>4000 cycles). Moreover, the finger motions and wrist pulse can be monitored in real time. These results demonstrate the potential application value and broad developmental prospects of carbonized cotton/thermoplastic polyurethane composites in flexible wearable electronics.

Design, Manufacture and Wind Tunnel Test of a Modular FishBAC Wing with Novel 3D Printed Skins

This paper introduces a new modular Fish Bone Active Camber morphing wing with novel 3D printed skin panels. These skin panels are printed using two different Thermoplastic Polyurethane (TPU) formulations: a soft, high strain formulation for the deformable membrane of the skin, reinforced with a stiffer formulation for the stringers and mounting tabs. Additionally, this is the first FishBAC device designed to be modular in its installation and actuation. Therefore, all components can be removed and replaced for maintenance purposes without having to remove or disassemble other parts. A 1m span, 0.27m chord morphing wing with a 25% chord FishBAC was built and tested mechanically and in a low-speed wind tunnel. Results show that the new design is capable of achieving the same large changes in airfoil lift coefficient (approximate ΔCL≈0.55) with a low drag penalty seen in previous FishBAC work, but with a much simpler, practical and modular design. Additionally, the device shows a change in the pitching moment coefficient of ΔCM≈0.1, which shows the potential that the FishBAC has as a control surface.

The Influence of the Material Type and the Placement in the Print Chamber on the Roughness of MJF-Printed 3D Objects

This paper describes a surface-roughness study performed on samples manufactured additively using the Multi Jet Fusion (MJF) technology. The samples were divided into three groups based on the material used in the process: polypropylene (PP), thermoplastic polyurethane (TPU), and polyamide 11 (PA11). Subsequently, they were tested by means of a roughness-measuring system, which made it possible to determine the typical surface roughness parameters (Ra, Rq, Rz). The tests were designed to examine whether the placement and orientation of 3D objects while printing, in connection with the material used, can significantly influence the surface quality of MJF-printed objects. The results show that the TPU samples have a surface roughness much higher than the PP and PA11 ones, which exhibit roughness levels very similar to each other. It can also be concluded that surfaces printed vertically (along the Z-axis) tend to be less smooth—similarly to the surfaces of objects made of TPU located in the central zones of the print chamber during printing. This information may be of value in cases where low surface roughness is preferred (e.g., manufacturing patient-specific orthoses), although this particular study does not focus on one specific application.