Evaluation of surgery and radiosurgery for acromegaly: A review of efficacy, complications, and follow-up

Background: Acromegaly is a rare disease caused by an over-increase in growth hormone (GH) and insulin-like growth factors. If left untreated, acromegaly is associated with many complications and increased mortality. The three modalities of treatment for this disease are surgery, pharmacotherapy, and radiotherapy. Another treatment option is stereotactic radiosurgery (SRS), which is used as an adjunct and alternative treatment in patients with acromegaly who are not suitable options for surgery. Methods: The present study is a review study conducted by searching the databases of Elsevier, PubMed, Springer, and Wiley, and using the keywords of acromegaly, treatment, transsphenoidal surgery, and radiosurgery. Fifteen studies, which had been performed between 2010 and 2021, were selected for review. Results: The results of these studies indicated that the use of SRS (LINAC SRS and GKRS) after surgery and medical treatment, before surgery and during radiotherapy improve biochemical and endocrine control and the quality of life of patients. However, due to some side effects of these treatments, it is necessary to conduct further studies in this field. Conclusion: All three modalities of treatment would be effective in acromegaly if used with appropriate indication in right sequence. Keywords: Pituitary Neoplasms, Pituitary Gland, Radiotherapy, Radiosurgery, Acromegaly

Download Full-text

Health-related quality of life in Turner syndrome and the influence of growth hormone therapy: a 20-year follow-up

Yearbook of Paediatric Endocrinology ◽

10.1530/ey.17.15.13 ◽

2020 ◽

Author(s):

Krantz E ◽

Landin-Wilhelmsen K ◽

Trimpou P ◽

Bryman I ◽

Wide U

Keyword(s):

Quality Of Life ◽

Growth Hormone ◽

Hormone Therapy ◽

Turner Syndrome ◽

Growth Hormone Therapy ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Download Full-text

Letter to the Editor: Comment on “Effect of Growth Hormone Treatment on Fractures and Quality of Life in Postmenopausal Osteoporosis: A 10-Year Follow-Up Study” by Kratz E., et al

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2015-3299 ◽

2015 ◽

Vol 100 (11) ◽

pp. L107-L107

Author(s):

Roberto Salvatori

Keyword(s):

Quality Of Life ◽

Growth Hormone ◽

Postmenopausal Osteoporosis ◽

Growth Hormone Treatment ◽

Hormone Treatment ◽

Editor Comment ◽

Follow Up Study ◽

Letter To The Editor

Download Full-text

Empowerment-based interventions in people with multiple sclerosis: a review study

Journal of Shahid Sadoughi University of Medical Sciences ◽

10.18502/ssu.v27i4.1354 ◽

2019 ◽

Author(s):

Sajjad Saadat ◽

Mehrdad Kalantari ◽

Mohammad Bagher Kajbaf ◽

Mozaffar Osseininezhad

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Chronic Disease ◽

Self Care ◽

Self Management ◽

Iranian Studies ◽

Male Patients ◽

Review Study

Introdution: Multiple sclerosis is a chronic disease in the nervous system; It has many problems due to its chronic and promising nature. The treatment of this disease includes medical care and empowerment interventions for symptom management. The purpose of this study was to review the empowerment interventions in these patients. Methods: This study was conducted in a Systematic Reviewperiod from January 2000 to June 2018. On indexing sites “Magiran, PubMed, Google Scholar and Science Direct” searched the key words of Multiple Sclerosis, Chronic Disease, Quality of Life, Self-care, Self-management, Rehabilitation, Empowerment, Psychotherapy, Psychological interventions, Clinical Trials, and Randomized Clinical Trial. Out of 1855 articles found, 33 articles were selected for review. Results: The results of this study showed that empowerment interventions in people with MS can be divided into four categories of self-care, self-management, rehabilitation and psychotherapy interventions. Lack of attention to empowerment interventions in people with MS, especially in the Iran, low attention to male patients in implementing interventions, failure to consider the theoretical framework in the formulation of interventions, lack of follow-up test and non-use of virtual intervention methods (Such as using DVDs, consulting and telephone training, etc.) in Iranian studies, is one of the most respected points in previous studies. Conclusion: Empowerment studies have provided significant results in reducing symptoms and improving the quality of life of patients, which can help improve these interventions by considering some of the points.

Download Full-text

Platelet rich plasma for the treatment of osteoarthrosis knee

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20170781 ◽

2017 ◽

Vol 3 (2) ◽

pp. 242

Author(s):

Prashant Maheshwari ◽

Hemeshwar Harshwardhan

Keyword(s):

Quality Of Life ◽

Growth Factors ◽

Platelet Rich Plasma ◽

Womac Score ◽

Knee Function ◽

Vas Scores ◽

The Mean ◽

Grade 3

Background: New studies focused on modern therapeutic methods which stimulate cartilage healing and repair the damage, including the use of platelet-rich plasma (PRP) as a cocktail of growth factors. This study has the purpose to present the use of PRP in management of knee osteoarthrosis and its outcomes up to 6 month follow up.Methods: 58 patients with 100 knees (32 male, 26 female) with Kellgren Lawrence grade 1, 2,3 and 4, aged between 50 to 65 years between February 2015 to December 2015 treated with 4 ml of intra-articular PRP injections at 4 week interval in each affected knee and evaluated using WOMAC and VAS scores before injection and on follow up at end of the 1st, 3rd, and 6th month.Results: The mean age was 58.29 years. Improvement in WOMAC score for KL grade 1 (32.61%), grade 2 (31.12%), grade 3(26.54%) whereas only 13.68% in KL grade 4 at end of 6month follow up. Improvement in VAS score for KL grade 1 (41.30%), grade 2 (38.02%), grade 3 (47.68) whereas only 12.74% in grade 4 at the end of 6 month follow up. Results show statistically higher significant improvement seen in WOMAC and VAS for KL grade 1, 2, and 3 as compared to grade 4 at 6 months follow up.Conclusions: The results of our study illustrated that the treatment with intra articular PRP injections is safe and effective in reducing pain and stiffness as well as improve knee function and quality of life in early stages of knee osteoarthrosis.

Download Full-text