scholarly journals A peculiar bilateral adrenal tumor: A case of asymptomatic left adrenal myelolipoma with right adrenal adenoma

2018 ◽  
Vol 9 ◽  
pp. 1
Author(s):  
Catherine Obadina ◽  
Cornelius Njoku ◽  
Okechukwu Mgbemena
Keyword(s):  
Adrenal Tumor ◽  
Adrenal Adenoma ◽  
Adrenal Myelolipoma ◽  
Bilateral Adrenal Tumor

scholarly journals Adrenal Incidentaloma: Challenges in Diagnosing Adrenal Myelolipoma

2019 ◽  
Vol 7 ◽  
pp. 232470961987031 ◽  
Author(s):  
Sreedhar Adapa ◽  
Srikanth Naramala ◽  
Vijay Gayam ◽  
Frank Gavini ◽  
Hemant Dhingra ◽  
...  
Keyword(s):  
Adrenal Tumor ◽  
Fluid Overload ◽  
Elevated Serum ◽  
Adrenal Incidentaloma ◽  
Uncontrolled Hypertension ◽  
Adrenal Tumors ◽  
Functional Aspect ◽  
Hematopoietic Tissue ◽  
Norepinephrine Level ◽  
Adrenal Myelolipoma

Adrenal myelolipomas (AMLs) are rare benign adrenal tumors, containing adipose and hematopoietic tissue, a result of reticuloendothelial cell metaplasia. Incidence on autopsy has been reported from 0.08% to 0.4%. AMLs are generally considered nonsecretory. The functional aspect of adrenal incidentaloma should be evaluated. In this article, we report a case of a 40-year-old male, who presented with uncontrolled hypertension and renal failure, with imaging revealing an adrenal incidentaloma. He was started on dialysis for acute fluid overload, and workup for pheochromocytoma revealed an elevated serum norepinephrine level of 1181 pg/mL. Free metanephrine and normetanephrine levels were low when checked pre- and post-dialysis. Complete resection of the encapsulated right adrenal mass was performed. Pathology of the adrenal tumor demonstrates an 11.5 × 9.5 × 7.5 cm well-circumscribed, partially encapsulated proliferation of mature adipose tissue with admixed hemopoietic elements consistent with myelolipoma weighing 29.3 g. This case highlights the inclusion of a full metabolic workup for all adrenal incidentalomas, including AML.

ADC histogram analysis for adrenal tumor histogram analysis of apparent diffusion coefficient in differentiating adrenal adenoma from pheochromocytoma

2016 ◽  
Vol 45 (4) ◽  
pp. 1195-1203 ◽  
Author(s):  
Tomokazu Umanodan ◽  
Yoshihiko Fukukura ◽  
Yuichi Kumagae ◽  
Toshikazu Shindo ◽  
Masatoyo Nakajo ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Adrenal Tumor ◽  
Adrenal Adenoma ◽  
Histogram Analysis ◽  
Apparent Diffusion

Bilateral adrenal tumor: causes and clinical features in eighteen cases

2008 ◽  
Vol 41 (3) ◽  
pp. 547-551 ◽  
Author(s):  
Jiaqiang Zhou ◽  
Dan Ye ◽  
Meihua Wu ◽  
Fenping Zheng ◽  
Fang Wu ◽  
...  
Keyword(s):  
Clinical Features ◽  
Adrenal Tumor ◽  
Bilateral Adrenal Tumor

scholarly journals Adrenocortical adenoma with myelolipomatous metaplasia: a potential diagnostic pitfall: a case report and review of the literature

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Mohammad Hossein Anbardar ◽  
Neda Soleimani ◽  
Saman Nikeghbalian ◽  
Maryam Mohebbi
Keyword(s):  
Case Report ◽  
Pancreatic Cyst ◽  
Imaging Techniques ◽  
Case Reports ◽  
Adrenal Adenoma ◽  
Adrenal Incidentaloma ◽  
Adrenocortical Adenoma ◽  
Complete Evaluation ◽  
Adrenal Myelolipoma ◽  
Lipomatous Tumors

Abstract Background Adrenal incidentalomas are often found during investigation for another tumor or unrelated problems. Except for adrenal myelolipoma (second most common primary adrenal incidentaloma following adrenocortical adenomas), adrenal lipomatous tumors are uncommon generally and are often described as case reports in the literature. Since the amount of fat is variable, without the help of advanced imaging techniques, some adrenal lipomatous tumors may be misdiagnosed before pathologic examination. Herein, we report a case of adrenal adenoma with myelolipomatous metaplasia that was excised as a periceliac mass in the setting of recurrent pancreatic cyst. Case report A 45-year-old Iranian woman with hypertension and end-stage renal disease presented with recurrence of a pancreatic cyst (previous pathologic report was mucinous cyst adenoma). During exploratory laparotomy, the mentioned pancreatic cyst was tightly attached to the stomach and jejunum. There was also a periceliac round rubbery lesion (firstly diagnosed by endoscopic ultrasound) that was excised for ruling out malignancy. Histologic examination of the periceliac mass was found to be adrenocortical adenoma with foci of myelolipomatous metaplasia. The pancreatic cyst histology was just a pseudocyst. Conclusion Our case highlights the significance of complete evaluation of incidental findings before surgical intervention, even in the setting of another primary tumor. Myelolipoma and myelolipomatous change (metaplasia) are two different entities. Although very similar as to pathogenesis, there are still some differences.

scholarly journals primer caso de feocromocitoma

2017 ◽  
Vol 3 (2) ◽  
pp. 54-58
Author(s):  
Alejandro Román González ◽  
Carlos Alfonso Builes Barrera ◽  
Johnayro Gutiérrez
Keyword(s):  
Multiple Endocrine Neoplasia ◽  
Adrenal Tumor ◽  
Multiple Endocrine Neoplasia Type ◽  
Panic Attacks ◽  
Hypertensive Retinopathy ◽  
Medullary Thyroid ◽  
Endocrine Neoplasia ◽  
History Of ◽  
Bilateral Adrenal Tumor

El feocromocitoma y el paraganglioma son tumores neuroendocrinos derivados de las células cromafines. El feocromocitoma está ubicado en la médula suprarrenal y el paraganglioma en los paraganglios. Esta enfermedad tiene un componente genético importante. Se considera infrecuente. En este artículo se presenta la historia del primer paciente reportado con feocromocitoma. Se trata de una mujer de 18 años alemana con palpitaciones, taquicardia, retinopatía hipertensiva, constipación y crisis de pánico que falleció en el Hospital de Friburgo de Brisgovia, en Alemania. La autopsia demostró la presencia de tumores adrenales bilaterales, 120 años después se confirmó la presencia de mutaciones en el proto-oncogen RET y los familiares de la paciente tenían feocromocitoma y carcinoma medular de tiroides. El primer caso conocido de feocromocitoma fue bilateral y secundario a una neoplasia endocrina múltiple tipo 2.AbstractPheochromocytoma and paraganglioma are neuroendocrine tumors arising from chromafin cells. Pheochromocytoma is located in the adrenal medulla and paraganglioma are located in the paraganglioma. This disease has a strong genetic component. It is a very rare disease. In this manuscript, the history of the first known report of pheochromocytoma is presented. An18-year-old woman from Germany presents with palpitations, tachycardia, hypertensive retinopathy, constipation and panic attacks. The patient died at the Freiburg Hospital in Germany. The autopsy showed the presence of bilateral adrenal tumor. A mutation in the proto-oncogen RET was demonstrated 120 years later. Relatives of the patient had pheochromocytoma and medullary thyroid carcinoma. The first known case of pheochromocytoma had bilateral disease secondary to multiple endocrine neoplasia type 2.

scholarly journals Experience of a Tertiary-Level Urology Center in Clinical Urological Events of Rare and Very Rare Incidence. V. Urological Tumors: 1. Adrenal Myelolipoma

2020 ◽  
Vol 14 (2) ◽  
pp. 85-91
Author(s):  
Rabea A. Gadelkareem ◽  
Ahmed M. Moeen ◽  
Mahmoud Khalil ◽  
Ahmed Reda ◽  
Mahmoud Farouk ◽  
...  
Keyword(s):  
Benign Tumor ◽  
Adrenal Tumor ◽  
Pathological Examination ◽  
Adrenal Tumors ◽  
Adrenal Myelolipoma ◽  
Promising Alternative ◽  
Alternative Approach ◽  
Laparoscopic Excision ◽  
Hospital Stay Duration ◽  
Characteristic Picture

Objectives: To present our center's experience in the management of adrenal myelolipoma in the context of shifting from the open to the laparoscopic adrenalectomy approach. Materials and Methods: A retrospective search of our center's records was done for reported cases of adrenal myelolipoma during the period July 2001-June 2016. All the cases with histopathologically-documented adrenal myelolipoma diagnosis were included. Relevant demographic and clinical variables were studied with a comparison between the open and laparoscopic approaches. Results: Of more than 82,000 urological surgeries, 238 adrenalectomies were done with only 22 cases of myelolipoma that had a mean age and body mass index of 52.4 ± 10.3 years and 30.23 kg/m2, respectively. The main clinical presentation was accidental discovery. The largest dimension of tumors varied from 6 to 16 cm. Computed tomography described a characteristic picture of hypodense heterogeneous adrenal tumors in all cases, while magnetic resonance imaging was indicated for malignancy suspicion in only 5 cases. Adrenal tumor markers were normal in all cases. Open and transperitoneal laparoscopic adrenalectomies were used in 14 and 8 cases, respectively. The latter approach was insignificantly advantageous in the need for blood transfusion, postoperative pain degree, need for analgesia, and hospital stay duration (p = 0.22). Histo-pathological examination revealed benign adipose tissue and myeloid cells and confirmed the diagnosis of adrenal myelolipoma in all cases. Conclusions: Adrenal myelolipoma is a rare non-functioning benign tumor. Laparoscopic excision seems to be a promising alternative approach to the traditional open adrenalectomy, even in the context of large tumors and obesity.

ADRENAL MYELOLIPOMA IN ASSOCIATION WITH NONFUNCTIONING ADRENAL ADENOMA AND CYSTIC RENAL ADENOCARCINOMA

1990 ◽  
Vol 83 (Supplement) ◽  
pp. 2S-93
Author(s):  
W. Stewart Bundrick ◽  
Daniel J. Culkin ◽  
John R. Adams ◽  
John A. Mata ◽  
Dennis D. Venable
Keyword(s):  
Adrenal Adenoma ◽  
Adrenal Myelolipoma ◽  
Renal Adenocarcinoma

scholarly journals Adrenal Cushing’s syndrome during pregnancy

2017 ◽  
Vol 177 (5) ◽  
pp. K13-K20 ◽  
Author(s):  
C E Andreescu ◽  
R A Alwani ◽  
J Hofland ◽  
L H J Looijenga ◽  
W W de Herder ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Cushing’S Syndrome ◽  
Adrenal Tumor ◽  
Cushing Syndrome ◽  
Adrenal Adenoma ◽  
Cushing's Syndrome ◽  
Receptor Expression ◽  
Aberrant Expression ◽  
Cortisol Responses

Cushing syndrome (CS) during pregnancy is a rare condition with only a few cases reported in the literature. Misdiagnosis of CS is common because of overlapping features like fatigue, weight gain, striae and emotional changes that can occur during normal pregnancy. Changes in maternal hormones and their binding proteins complicate assessment of glucocorticoid hormone levels during gestation. CS during pregnancy is most frequently due to an adrenal adenoma and to a lesser degree to adrenocorticotropic hormone (ACTH) hypersecretion by a pituitary adenoma. Furthermore, aberrant expression of luteinizing hormone (LH) receptors in the adrenal cortex has been suggested to be involved in the pathogenesis of adrenal CS during pregnancy. We report three pregnant women with ACTH-independent Cushing’s syndrome and an adrenal tumor. After uncomplicated delivery, patient 1 underwent in vivo testing for aberrant hormone receptor expression by the adenoma. Cortisol responses were found after administration of luteinizing hormone-releasing hormone (LHRH), human chorionic gonadotropin (hCG), glucagon, vasopressin and a standard mixed meal. All patients were treated with laparoscopic adrenalectomy. Adrenal tumor tissue of two patients showed positive immunohistochemical staining of LH receptors. Considering the cortisol responses to LHRH and hCG, and the development of CS during pregnancy in these patients, it is likely that ACTH-independent hypercortisolism was induced by the pregnancy-associated rise in hCG levels that activated aberrantly expressed LH receptors in the adrenal adenoma. Remarkably, adrenal adenomas may simultaneously express multiple aberrant receptors and individual ligands may play a role in the regulation of cortisol production in CS during pregnancy.

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