The effects of castration and testosterone replacement on the gene expression of adrenomedullin and its receptor component proteins in the rat epididymis, seminal vesicle and coagulating gland

2009 ◽  
Author(s):  
Pik-fan Wong
Keyword(s):  
Gene Expression ◽  
Seminal Vesicle ◽  
Testosterone Replacement ◽  
Receptor Component ◽  
Rat Epididymis ◽  
Coagulating Gland

1399: Expression of Luteinizing Hormone and its Receptor in the RAT Epididymis and Seminal Vesicle

2004 ◽  
Vol 171 (4S) ◽  
pp. 368-369
Author(s):  
Sung Ho Lee ◽  
Soo Woong Kim ◽  
Jae-Seung Paick
Keyword(s):  
Luteinizing Hormone ◽  
Seminal Vesicle ◽  
Rat Epididymis

Role of homeobox pathway in prostate carcinogenesis.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 126-126
Author(s):  
James Lin Chen ◽  
Kristen Otto ◽  
Donald Vander Griend
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Seminal Vesicle ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Protein Network ◽  
Gene Profiling ◽  
Normal Prostate ◽  
Survival Difference

126 Background: Identifying aberrant activity of developmental pathways in prostate cancer provides therapeutic opportunities. To this end, despite a shared embryonic origin and similarities to prostate cancer in histology and androgen dependence, seminal vesicle cancer is exceptionally rare. Genomic pathway analyses of their critical developmental differences may reveal uncharacterized oncogenic pathways. Previous attempts to do so have used whole tissue preparations. We hypothesized that careful gene profiling of pure primary epithelial cultures from normal prostate and seminal vesicles would reduce confounding noise during analysis and provide more robust pathway prioritization. Methods: Paired normal prostate and seminal vesicle epithelium cultures were created from three de-identified patients. Derived gene expression profiles were grouped into cancer biomodules using a protein-protein network algorithm to analyze their relationship to known oncogenes. Each resultant biomodule was assayed for its prognostic ability in independent Kaplan-Meier analyses of prostate cancer patients for time to recurrence and overall survival. Protein products from prioritized biomodule genes were then evaluated in vitro. Results: Gene expression profiling and protein network prioritization resulted in three cancer biomodules. Survival analysis revealed that the embryonic developmental biomodule centered on homeobox genes Meis1, Meis2 and Pbx1 to have clinical import. This homeobox biomodule detected a survival difference in a set of active surveillance patients (n=172, p=0.05) and identified men who were more likely to recur biochemically post-prostatectomy (n=78, p=0.02). We analyzed in vitro protein expression of Meis1, Meis2, Pbx1 and confirmed decreased gene expression in independent datasets of prostate cancer versus normal tissue. Conclusions: The Meis1/Meis2/Pbx1 biomodule may explain key differences in seminal vesicle and normal prostate epithelium development. In contrast to other cancers, Meis1, Meis2, and Pbx1 may play a tumor suppressor role in prostate cancer. Thus deregulation of this biomodule may be critical in prostate cancer oncogenesis.

scholarly journals Purification and identification of transglutaminase from mouse coagulating gland and its cross-linking activity among seminal vesicle secretion proteins

2008 ◽  
Vol 876 (2) ◽  
pp. 198-202 ◽  
Author(s):  
Huan-Chin Tseng ◽  
Han-Jia Lin ◽  
P.S. Sudhakar Gandhi ◽  
Chia-Yih Wang ◽  
Yee-Hsiung Chen
Keyword(s):  
Seminal Vesicle ◽  
Cross Linking ◽  
Vesicle Secretion ◽  
Coagulating Gland

scholarly journals Studies on the metabolic role of myo-inositol. Distribution of radioactive myo-inositol in the male rat

1976 ◽  
Vol 156 (2) ◽  
pp. 375-380 ◽  
Author(s):  
L M Lewin ◽  
Y Yannai ◽  
S Sulimovici ◽  
P F Kraicer
Keyword(s):  
Seminal Vesicle ◽  
Trichloroacetic Acid ◽  
Lipid Fraction ◽  
Prostate Gland ◽  
Radioactive Material ◽  
Male Rat ◽  
Metabolic Role ◽  
Muscle Tissues ◽  
Coagulating Gland

Radioactive myo-inositol was injected intraperitoneally into nephrectomized rats. The radioactive material present in liver, spleen, brain, heart, diaphragm, seminal vesicle, coagulating gland, prostate, epididymis, vas deferens and testis was shown to consist exclusively of myo-inositol and its derivatives, as shown by paper chromatography of hydrolysates and trichloroacetic acid extracts of these tissues. Radioactive myo-inositol was accumulated rapidly within 1 h by the thyroid, coagulating gland and seminal vesicle. Other tissues, such as the pituitary, prostate gland, liver and spleen, concentrated myo-inositol less actively. The muscle tissues studied (diaphragm and heart) concentrated little inositol, whereas brain, testis, and epididymal fat-pad did not concentrate it at all. The lipid fraction of liver contained most of the radio-labelled myo-inositol. In the other organs most of the radioactivity was found in the aqueous trichloroacetic acid extract, largely as free myo-inositol.

Metabolic activity in tissue transplants. Hormone-induced formation of fructose and citric acid in transplants from accessory glands of reproduction

1949 ◽  
Vol 136 (884) ◽  
pp. 461-471 ◽  
Keyword(s):  
Citric Acid ◽  
Seminal Vesicle ◽  
Hormone Treatment ◽  
Female Rats ◽  
Accessory Glands ◽  
Tissue Transplants ◽  
Male Sex ◽  
Coagulating Gland ◽  
Metabolic Behaviour

A combined chemical and cytological study of the behaviour of transplants from certain accessory glands of reproduction in the rat was carried out. It was found that subcutaneous transplants of coagulating gland and seminal vesicle were capable of producing considerable amounts of fructose and citric acid in total anatomical separation from the male reproductive system. In transplants containing coagulating gland and seminal vesicle tissue both fructose and citric acid were formed. In those from coagulating gland alone only fructose was produced, but citric acid was absent. In this respect the metabolic behaviour of the grafts was identical with that of the intact organs. Following castration, coagulating gland transplants lost their ability to form fructose. This was fully restored by treatment with testosterone propionate. Upon cessation of the hormone treatment the process of fructose formation in the transplants was again brought to a standstill. Grafts of coagulating gland could be successfully grown in female rats and brought to a state of fructose secretion by subjecting the female hosts to injections of male sex hormone. The post-castrate retrogressive changes as well as the hormone-induced recovery symptoms were studied in the transplants parallel with similar changes in the intact glands in situ . The chemical findings were corroborated by the histological examination.

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