Correlation between ABCB1 C3435T gene polymorphism and clopidogrel resistance：a meta analysis

Objective： To systematically evaluate the correlation between ABCB1 C3435T gene polymorphism and clopidogrel resistance（CR）.Methods： The databases，such as Wanfang Data，the Chinese Biomedical Literature Database（CBM），the Chinese Journal Fulltext Database in China National Knowledge Infrastructure（CNKI），the China Science and Technology Journal Database（VIP），Science Citation Index（SCI），PubMed and EMBase，were searched from the inception to October 2019.The quality of clinical studies which met the inclusion criteria was evaluated，and meta analysis was performed using Stata 14.0 software.Results： Ten papers were included and 2642 patients were enrolled，including 878 cases in the clopidogrel-resistance group and 1764 cases in the non-clopidogrel resistance group.Results of meta-analysis showed that due to ABCB1 C3435T gene polymorphism，the overall effect of each subgroup was statistically significant（P<0.05）： allele gene model OR=1.39，95% CI（1.07，1.81）， dominant gene model OR=1.37，95% CI（1.13，1.66），recessive gene model OR=1.62，95% CI（1.02，2.57）， homozygous gene model OR=1.92，95% CI（1.14，3.22），and heterozygous gene model OR=1.33，95% CI（1.06，1.66）.Conclusion： Current findings confirmed that ABCB1 C3435T gene polymorphism is associated with clopidogrel resistance.

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Acupuncture for Obstructive Sleep Apnea (OSA) in Adults: A Systematic Review and Meta-Analysis

BioMed Research International ◽

10.1155/2020/6972327 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Liaoyao Wang ◽

Jia Xu ◽

Yijun Zhan ◽

Jian Pei

Keyword(s):

Subgroup Analysis ◽

Assessment Tool ◽

Meta Analysis ◽

Biomedical Literature ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Obstructive Sleep ◽

Clinically Significant

Objective. Our aim was to assess the efficacy and safety of acupuncture for OSA patients with various severities of the disorder. Methods. Eight databases including PubMed, Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese Biomedical Literature Database (CBM) were comprehensively searched till July 2019. Randomized controlled trials (RCTs) testing acupuncture in the treatment of OSA were eligible for inclusion. Studies were selected for inclusion, and data were extracted by two authors independently. The Cochrane Collaboration’s Risk of Bias Assessment Tool and RevMan software (version 5.3) were used to evaluate the quality of studies and conduct statistical analysis. Results. Nine RCTs with 584 participants were included. The trials covered acupuncture and electropuncture. Acupuncture caused clinically significant reductions in AHI (MD: -6.18; 95% CI: -9.58 to -2.78; Z=3.56, P=0.0004) as well as in ESS (MD: -2.84; 95% CI: -4.80 to -0.16, Z=2.09, P=0.04). AHI was reduced more in the subgroup analysis of moderate OSA patients (MD: -9.44; 95% CI: -12.44 to -6.45; Z=6.18, P<0.00001) and severe OSA patients (MD: -10.09; 95% CI: -12.47 to -7.71; Z=8.31, P<0.00001). ESS was also reduced more in the subgroup analysis of moderate OSA patients (MD: -2.40; 95% CI: -3.63 to -1.17; Z=3.83, P=0.0001) and severe OSA patients (MD: -4.64; 95% CI: -5.35 to -3.92; Z=12.72, P<0.00001). Besides, acupuncture had a beneficial effect on LSaO2 (MD: 5.29; 95% CI: 2.61 to 7.97; Z=3.86, P=0.0001). The outcome of AHI and LSaO2 yielded consistent results after sensitivity analysis, but the direction of the outcome of ESS was reversed. And the quality of evidence was mainly low to very low. Conclusions. Acupuncture therapy is effective for OSA patients in reducing AHI and ESS and in improving the LSaO2 of various severities, especially in moderate and severe OSA patients. High-quality trials are urgently needed.

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Does propofol ameliorate occurrence of postoperative cognitive dysfunction after general anaesthesia? A protocol of systematic review

Systematic Reviews ◽

10.1186/s13643-021-01610-y ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Xi Zhao ◽

Ze-qing Huang

Keyword(s):

Systematic Review ◽

Cognitive Dysfunction ◽

Short Term Memory ◽

Meta Analysis ◽

Postoperative Cognitive Dysfunction ◽

Biomedical Literature ◽

Cochrane Library ◽

Efficacy And Safety ◽

China National Knowledge Infrastructure

Abstract Background Postoperative cognitive dysfunction (POCD) is a common condition after general anesthesia (GA). Previous studies have reported that propofol can ameliorate the occurrence of such disorder. However, its results are still inconsistent. Therefore, this systematic review will assess the efficacy and safety of propofol on POCD after GA. Methods Literature sources will be sought from inception to the present in Cochrane Library, MEDLINE, EMBASE, PsycINFO, Web of Science, Scopus, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure for randomized controlled trials (RCTs) assessing the administration of propofol on POCD after GA. All searches will be carried out without limitations to language and publication status. Outcomes comprise of cognitive impairments changes, impairments in short-term memory, concentration, language comprehension, social integration, quality of life, and adverse events. Cochrane risk of bias tool will be utilized to assess study quality. We will evaluate the quality of evidence for each outcome using Grading of Recommendations Assessment, Development and Evaluation approach. A narrative synthesis or a meta-analysis will be undertaken as appropriate. Discussion This study will systematically and comprehensively search literature and integrate evidence on the efficacy and safety of propofol on POCD after GA. Our findings will be of interest to clinicians and health-related policy makers. Systematic review registration PROSPERO CRD42020164096

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Efficacy and Safety of Modified Yunu-Jian in Patients with Periodontitis: A Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/5147439 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Yuanyuan Yue ◽

Meng Gao ◽

Yanru Deng ◽

Jiemin Shao ◽

Yingguang Sun

Keyword(s):

Western Medicine ◽

Combined Therapy ◽

Meta Analysis ◽

Effective Rate ◽

Cochrane Library ◽

Efficacy And Safety ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Oral Inflammation

Background. Modified Yunu-Jian (mYJ), a Chinese medicine (CM) formula, is thought to clear heat and nourish yin. Clinically, it is often used to treat oral inflammation. However, its efficacy remains controversial. Methods. The study aims to evaluate the efficacy and safety of mYJ for treating patients with periodontitis. We searched electronic databases (PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure, Wanfang database, VIP database, and CBM) from inception to December 2020. Only randomized controlled trials investigating modified Yunu-Jian, with or without other medications, against controlled intervention in the treatment of patients diagnosed with periodontitis were included. Both Review Manager 5.3 and Stata 15.0 software were used to analyze the data. The Cochrane Collaborations risk of bias tool was used to assess the quality of the methods. Results. Thirteen clinical trials, involving 1179 participants, were included in our investigation. The results showed that the combination of mYJ with western medicine improved the total effective rate compared with western medicine alone (RR = 1.17, 95% CI (1.12, 1.23), P < 0.00001). The sensitivity analysis and Harbord’s test ( P = 0.255) both showed that the results were statistically robust. Moreover, the periodontal indexes (GI, SBI, PLI, and PD; P < 0.00001) of patients with periodontitis were also significantly improved after receiving the combined therapy. No serious adverse reactions were observed in the experimental groups. Conclusions. Evidence from the meta-analysis suggested that mYJ appeared to be effective and relatively safe for treating periodontitis. Because of the low quality of the methods used in the included RCTs, further studies with larger sample sizes and well-designed models are required to confirm our findings.

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Manual Acupuncture for Optic Atrophy: A Systematic Review and Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/1735967 ◽

2019 ◽

Vol 2019 ◽

pp. 1-12 ◽

Cited By ~ 1

Author(s):

Fang-Yuan Zhi ◽

Jie Liu ◽

Xiao-Peng Ma ◽

Jue Hong ◽

Ji Zhang ◽

...

Keyword(s):

Systematic Review ◽

Optic Atrophy ◽

Meta Analysis ◽

Biomedical Literature ◽

Cochrane Library ◽

Controlled Clinical Trial ◽

Manual Acupuncture ◽

Knowledge Infrastructure ◽

Clinical Trials Registry

Objectives. This systematic review aims to critically evaluate the efficacy of manual acupuncture for optic atrophy. Eight English and Chinese databases, including Cochrane Library, EMbase, PubMed, Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), and Chinese Biomedical Literature Database (CBM), as well as ongoing trials registered with the WHO International Clinical Trials Registry Platform, were searched to identify eligible randomized controlled trials (RCTs) studying manual acupuncture for optic atrophy compared to medication alone. The quality of evidence was assessed using Cochrane Collaboration’s risk of bias tool. Meta-analysis was performed using Review Manager version 5.3. Nine studies were identified and included for meta-analysis. The meta-analysis showed significant differences in favor of manual acupuncture or manual acupuncture plus medication compared with medication alone in the following outcome measures: visual acuity (MD = 0.18, 95% CI [0.17, 0.20], P < 0.00001), mean sensitivity of visual field (MD = 2.11, 95% CI [1.90, 2.32], P < 0.00001), the latent period of P-VEP100 (MD = -6.80, 95% CI [-8.94, -4.66], P < 0.00001), the total effectiveness (264 eyes) (OR = 3.22, 95% CI [1.88, 5.51], P<0.0001), and the total effectiveness (344 participants) (OR = 4.29, 95% CI [2.56, 7.19], P < 0.00001). Despite statistical advantages of manual acupuncture in the literature, due to serious methodological flaws in study design, it cannot be concluded that manual acupuncture is more effective than medicine alone. It is essential that a properly controlled clinical trial is designed and controls are established to exclude placebo effects.

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Effectiveness and Safety of Plum - Blossom Needle in the Treatment of Myopia：A Protocol for Systematic Review and Meta-analysis

10.21203/rs.3.rs-73070/v1 ◽

2020 ◽

Author(s):

Siyuan Zhu ◽

Jun Xiong ◽

Jun Chen ◽

Genhua Tang ◽

Lunbin Lu ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Scientific Journal ◽

Biomedical Literature ◽

Systematic Evaluation ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Myopia Progression ◽

Knowledge Infrastructure ◽

The Cochrane Library

Abstract Background: In recent years, the prevalence of myopia has increased significantly, and it has become one of the major eye diseases that cause visual impairment in the world,which is particularly prominent among young people. And uncorrected myopia is the leading cause of blindness.The purpose of this study is to evaluate the efficacy and safety of plum-blossom needle in delaying adolescent myopia progression through systematic evaluation.Methods and analysis:The following electronic databases will be searched from inception to July 2020 regardless of publication status and language: Medline, EMBASE, Web of Science, the Cochrane Library, PubMed, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), Chinese Scientific Journal Database (VIP), Wanfang Database, Chinese Biomedical Literature Database (CBLD), Chinese Science and Technology Periodical Database (CSTPD). RCT registration websites, including http://www.ClinicalTrials.gov and http://www.chictr.org.cn, will also be searched. Review Manager V.5.4 will be used to analysis the statistic. Two reviewers will independently select studies, extract and code the data, assess risk of bias of the included studies, evaluate the quality of evidence for outcomes.Discussion:So far, many studies have been conducted on the treatment of adolescent myopia with plum-blossom needles. However, there is still no clear conclusion on the effectiveness and safety of plum-blossom needles in the treatment of juvenile myopia.In this systematic review and meta-analysis, available data will be pooled together to further inform research and clinical practice.Systematic review registration: Inplasy protocol 202080026

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Efficacy of Qigong Exercise for Treatment of Fatigue: A Systematic Review and Meta-Analysis

Frontiers in Medicine ◽

10.3389/fmed.2021.684058 ◽

2021 ◽

Vol 8 ◽

Author(s):

Rui Wang ◽

Xueyan Huang ◽

Yeqi Wu ◽

Dai Sun

Keyword(s):

Meta Analysis ◽

Chronic Fatigue ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Patients With Cancer ◽

Fatigue Syndrome ◽

Knowledge Infrastructure ◽

Standard Mean Difference ◽

Significant Difference

Objective: Several studies suggested that Qigong exercise (QE) can relieve fatigue in patients diagnosed with various diseases. Our review aimed to evaluate the efficacy of QE for alleviating fatigue.Methods: A related literature search was performed in the PubMed, Web of Science, Embase, Cochrane Library, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI), Wanfang, and VIP data bases from inception to November 2020. Information on fatigue, malaise, tiredness, and Qigong research data was collected.Results: Sixteen randomized controlled trials (RCTs) were reported in patients with cancer (n = 4), chronic fatigue syndrome (n = 2), and other diseases (n = 10). The QE groups showed significant improvements in total fatigue intensity [15 RCTs, p < 0.00001; standard mean difference (SMD) −0.69 (−0.95 to −0.44)]. The QE groups did not show significant improvement in quality of life [4 RCTs, p = 0.08; SMD 0.53 (−0.07 to 1.14)]. The statistically significant difference of the subgroup analyses (different primary diseases, QE types, and study quality) also remained unchanged.Conclusion: The findings of this meta-analysis indicate that QE may be beneficial for improving fatigue in patients diagnosed with various diseases. Considering the limitations of the study, we draw a very cautious conclusion regarding the resulting estimate of the effect. Further studies are warranted to better understand the benefits of QE in primary medical care.

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MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Genes and Environment ◽

10.1186/s41021-021-00208-z ◽

2021 ◽

Vol 43 (1) ◽

Author(s):

Xiaobo Dong ◽

Jun Wang ◽

Gesheng Wang ◽

Jiayue Wang ◽

Lei Wang ◽

...

Keyword(s):

Gene Polymorphism ◽

Stroke Risk ◽

Genetic Model ◽

Meta Analysis ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Potential Association ◽

Dominant Genetic Model ◽

Stroke Type

Abstract Background Previous studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. But the results of published studies remained inconclusive and controversial. So we conducted a meta-analysis to accurately estimate the potential association between MTHFR A1298C gene polymorphism and stroke susceptibility. Methods A systematic literature search on Embase, Pubmed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) and WanFang electronic database identified 40 articles including 5725 cases and 8655 controls. Strength of association was evaluated by pooled odds ratio (OR), 95% confidence interval (CI) and p value. Funnel plots and Begger’s regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0. Results The meta-analysis results indicated a significant relationship between MTHFR gene A1298C polymorphisms and stoke risk under the C allelic genetic model (OR = 1.19, 95%CI = 1.07–1.32, p = 0.001), dominant genetic model (OR = 1.19, 95%CI = 1.06–1.33, p = 0.004) and recessive genetic model (OR = 1.43, 95%CI =1.15–1.77, p = 0.001). In subgroup analysis, we discovered obvious correlation in three genetic model of Asian, stroke type, adult by ethnicity, population, stroke type, source of control and case size. Additionally, in studies of control from hospital and case size equal 100, obvious correlation was also found in the three genetic model. Conclusions Our meta-analysis results indicated that there was evidence to support the correlation between MTHFR A1298C polymorphism and stroke susceptibility, especially in adults and ischemic stroke.

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Pulmonary Rehabilitation for Exercise Tolerance and Quality of Life in IPF Patients: A Systematic Review and Meta-Analysis

BioMed Research International ◽

10.1155/2019/8498603 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9 ◽

Cited By ~ 6

Author(s):

Xueqing Yu ◽

Xuanlin Li ◽

Liaoyao Wang ◽

Ran Liu ◽

Yang Xie ◽

...

Keyword(s):

Quality Of Life ◽

Pulmonary Rehabilitation ◽

Data Extraction ◽

Meta Analysis ◽

Biomedical Literature ◽

Cochrane Library ◽

Efficacy And Safety ◽

China National Knowledge Infrastructure ◽

Single Breath

Objective. The aim of this study is to evaluate the efficacy and safety of pulmonary rehabilitation (PR) in patients with idiopathic pulmonary fibrosis (IPF).Methods. Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese Biomedical Literature Database (SinoMed) were comprehensively searched. Randomized controlled trials (RCTs) that investigated the effects of PR for IPF patients were included. Literature selection and data extraction were conducted by two review authors independently. The Cochrane Collaboration’s Risk of Bias tool and RevMan software (version 5.3) were used to evaluate the quality of studies and conduct statistical analysis, respectively.Results. Seven studies (190 participants) were included. PR had a significant effect on six-minute walk distance (6MWD) (MD:48.60; 95%CI: 29.03 to 68.18;Z=4.87,P<0.00001), and 6MWD was improved more in subgroup analysis including studies conducted in Asia (MD: 53.62; 95%CI: 30.48 to 76.66;Z=4.54,P<0.00001) and Europe (MD:54.10; 95% CI: 26.65 to 101.56;Z=2.23,P=0.03). Forced vital capacity (FVC%) was higher (MD: 3.69; 95%CI: 0.16 to 7.23;Z=2.05,P=0.04). St. George’s Respiratory Questionnaire (SGRQ)/IPF-specific SGRQ (SGRQ-I) total score was lower (MD: -7.87; 95% CI: -11.44 to -4.30;Z=4.32,P<0.0001). No significant effects were found for lung diffusing capacity determined by the single-breath technique (DLCO%) (MD: 3.02; 95%CI: -0.38 to 6.42;Z=1.74,P=0.08).Conclusions. This study suggests that PR may enhance exercise capacity and improve quality of life in IPF patients. Besides, PR may also delay the decline of lung function of patients with IPF. However, further research should more fully assess the efficacy and safety of PR for IPF.

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Gene Polymorphism and Precocious Puberty: A Meta-Analysis of Case-Control Studies

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.647.466 ◽

2013 ◽

Vol 647 ◽

pp. 466-470 ◽

Cited By ~ 1

Author(s):

Min Jie Zhang ◽

Zong Lin Gong ◽

Di Han ◽

Xiang Gao ◽

Qi Tan ◽

...

Keyword(s):

Gene Polymorphism ◽

Precocious Puberty ◽

Independent Risk Factor ◽

Meta Analysis ◽

Control Sample ◽

Case Control ◽

Case Control Studies ◽

China National Knowledge Infrastructure ◽

Medline Search ◽

Knowledge Infrastructure

Objective: To reexamine literature and data on the effects of gene polymorphism on precocious puberty via a meta-analysis. Methods: Consultation of search engines Chinese Bio-medicine Database, China National Knowledge Infrastructure, Pubmed and Medline search resulted in a total of seven studies containing more than 4300 individuals from various ethnic backgrounds. To evaluate the risk of precocious puberty, odds ratios (OR) for all case-control studies were calculated. Results: In this meta-analysis no significant association of the gene polymorphism with precocious puberty in the combined case-control sample (OR=1.19, 95%CI: 0.88-1.62, P=0.26) was found. Conclusion: This study found no evidence of gene polymorphism being an independent risk factor of precocious puberty. Further studies are needed further understand the effects of the interactions between these genes and other genetic and/or environment factors on precocious puberty.

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Evaluation of the effectiveness and safety of cupping therapy in the treatment of asthma : A protocol for systematic review and meta-analysis

10.37766/inplasy2021.8.0104 ◽

2021 ◽

Author(s):

Lei Guo ◽

◽

Zhongtian Wang ◽

Lina Wei ◽

Lizhong Ding ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Cupping Therapy ◽

Biomedical Literature ◽

China National Knowledge Infrastructure ◽

Aggregated Data ◽

Knowledge Infrastructure ◽

Asthma Patients ◽

Ethical Approval ◽

Review Question

Review question / Objective: “The aim of this systematic review is to compare Cupping therapy and Non cupping therapy in terms of efficacy and acceptability in the asthma to better inform clinical practice. To this end, the proposed systematic review will address the following question: Which is the best choice to reduce PEF, FVC, and FEV1, in asthma patients, Cupping therapy or Non cupping therapy ?”. Information sources: The protocol was prepared based on the preferred reporting project of the systematic review and meta-analysis protocol statement guidelines. Our research does not require ethical approval, as all analyses will be based on aggregated data from previously published studies. We will search the following Chinese and English databases: China National Knowledge Infrastructure, China Science and Periodical Database, Wanfang Database, China Biomedical Literature Database, PubMed, Embase, Cochrane Library.All of the above electronic databases will be searched from inception to August 22, 2021. In addition, we will manually search for conference papers, ongoing experiments and internal reports to supplement the studies retrieved via electronic search.

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