A Comparative Study To Evaluate The Role Of Inhaled Steroid Versus Low Dose oral Steroid In Patients Of COPD

To compare the treatment effects of a high-dose and low-dose oral steroid regimen based on changes in the radioisotope uptake ratio (RUR) observed from three-phase bone scintigraphy (TPBS) in patients with complex regional pain syndrome type I (CRPS I), we retrospectively analyzed data of 34 patients with CRPS I from traumatic brain injury and stroke. Depending on the dose of steroid administered, patients were divided into high-dose (n = 14) and low-dose steroid groups (n = 20). We compared the severity scores, Kozin’s classification scores, and RUR observed from TPBS between the two groups. There were significant changes in the severity scores and Kozin’s classification between the baseline and 2 weeks from baseline (p < 0.05), however, there were no significant differences in terms of changes in the scores, classification, or the RUR observed from TPBS at 2 weeks from baseline (p > 0.05). There were no treatment-emergent adverse events (TEAEs) such as blood pressure elevation, impaired glycemic control, or gastrointestinal disturbances. Our results indicate that the efficacy profile of a low-dose oral steroid regimen is comparable to that of a high-dose regimen in alleviating symptoms in CRPS I patients. However, additional prospective, large-scale, multi-center studies are warranted to confirm our results.

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Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study

International Journal of Dermatology ◽

10.1111/ijd.12191 ◽

2013 ◽

Vol 53 (1) ◽

pp. 114-122 ◽

Cited By ~ 23

Author(s):

Edileia Bagatin ◽

Lilia R. S. Guadanhim ◽

Milvia M. S. S. Enokihara ◽

Adriana Sanudo ◽

Sérgio Talarico ◽

...

Keyword(s):

Retinoic Acid ◽

Comparative Study ◽

Low Dose ◽

Dose Oral ◽

Oral Isotretinoin

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763 ROLE OF MIDAZOLAM ADDED TO LOW DOSE HYPERBARIC BUPIVACAINE IN SUB-ARACHNOID BLOCK FOR LOWER UTERINE CAESAREAN SECTION - A COMPARATIVE STUDY

European Journal of Pain ◽

10.1016/s1090-3801(06)60766-0 ◽

2006 ◽

Vol 10 (S1) ◽

pp. S199-S199

Author(s):

A.K.M. Akhtaruzzaman ◽

A.K. Agarwal ◽

K.M. Iqbal

Keyword(s):

Caesarean Section ◽

Comparative Study ◽

Low Dose ◽

Hyperbaric Bupivacaine

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Short-term Low-dose Oral Corticosteroid Therapy of Impingement Syndrome of the Shoulder: A Comparison of the Clinical Outcomes to Intra-articular Corticosteroid Injection

Clinics in Shoulder and Elbow ◽

10.5397/cise.2014.17.2.50 ◽

2014 ◽

Vol 17 (2) ◽

pp. 50-56

Author(s):

Young Bok Kim ◽

Young Chang Kim ◽

Ji Wan Kim ◽

Sang Jin Lee ◽

Sang Won Lee ◽

...

Keyword(s):

Clinical Outcomes ◽

Corticosteroid Therapy ◽

Low Dose ◽

Oral Corticosteroid ◽

Impingement Syndrome ◽

Oral Steroid ◽

Short Term ◽

Dose Oral ◽

Ucla Score ◽

Oral Corticosteroid Therapy

BACKGROUND: To assess the clinical outcomes of short-term oral corticosteroid therapy for impingement syndrome of the shoulder and determine whether it can be substituted as an alternative to the intra-articular injection.METHODS: The clinical outcomes of the 173 patients, the oral steroid group (n=88) and the injection group (n=85), were measured at 3 weeks, 2, 4, and 6 months postoperatively. The clinical outcomes were assessed by measuring the the University of California at Los Angeles (UCLA) score, visual analog scale (VAS) and range of motion (ROM) at every follow-up. Any complications and recurrence rate were noted. A relationship between the treatment outcomes and factors such as demographic factors, clinical symptoms and radiographic findings were determined.RESULTS: No difference was observed in VAS and UCLA scores between the two groups, but forward flexion and internal rotation of ROM were significantly improved in the injection group at the 2nd and 4th postoperative month (p < 0.05). At 6th postoperative month, recurrence rate of symptoms was 26% in the oral steroid group and 22% in the injection group. No major adverse effects were observed. When the clinical outcomes of the oral steroid group were compared to either demographic, clinical symptoms, or radiographic findings, UCLA score was found to be significantly low (p < 0.05) in patients with joint stiffness and UCLA score, whereas VAS score was significantly improved in patients with night pain (p < 0.05).CONCLUSIONS: Short-term low-dose oral corticosteroid therapy of impingement syndrome showed comparable clinical outcomes to intra-articular injection without any remarkable adverse effects. Low-dose oral steroids can be regarded as a partial alternative to intra-articular injection for the initial therapy of impingement syndrome of the shoulder.

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Pembrolizumab-induced myasthenia gravis-like disorder, ocular myositis, and hepatitis: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-021-02722-8 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Chia-Yi Tian ◽

Yang-Hao Ou ◽

Shih-Liang Chang ◽

Chih-Ming Lin

Keyword(s):

Myasthenia Gravis ◽

Urothelial Carcinoma ◽

Low Dose ◽

Oral Steroid ◽

High Grade ◽

Bilateral Ptosis ◽

Programmed Death ◽

Number Of Patients ◽

Oral Steroids ◽

Dose Oral

Abstract Introduction Pembrolizumab and other immune checkpoint inhibitors are the emerging treatment for selected, high-grade malignancies. However, a small number of patients are unable to tolerate its adverse effects, leading to discontinuation of this potentially life-changing therapy. In this study, we present a case of high-grade urothelial carcinoma patient, who experienced neurocomplications during the first pembrolizumab administration. However, we were able to limit the adverse effect by concomitant use of low-dose oral steroids. Case presentation A 75-year-old Taiwanese female with high-grade urothelial carcinoma of the left ureter came to the neurology clinic with complaints of acute onset of bilateral ptosis 16 days after her first infusion of pembrolizumab. It was found that she developed complete bilateral ptosis and limited extraocular muscle movements. Myasthenia gravis-related antibodies and repetitive stimulation test were negative. We diagnosed her with pembrolizumab-induced myasthenia gravis-like disorder and myositis based on clinical symptoms and elevation of muscle enzymes. We commenced methylprednisolone pulse therapy followed by oral steroid therapy with gradual resolution of the symptoms. Three months later, the patient received a second cycle of pembrolizumab with low-dose oral steroids without any complications. Conclusion Pembrolizumab exerts its antitumor activity by interfering with the binding of programmed death 1 and its ligand, programmed death ligand 1. As a result, enhanced cytotoxic T cells can recognize tumor cells and induce cellular death. However, neurological complications may be severe and require prompt recognition and treatment. Our case demonstrated that concomitant use of low-dose steroids and pembrolizumab might prevent such complications.

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Role of CTLA-4, IL-18 and IL-10 on the Induction of Low Dose Oral Tolerance

Journal of the Kentucky Academy of Science ◽

10.3101/1098-7096(2008)69[11:rociai]2.0.co;2 ◽

2008 ◽

Vol 69 (1) ◽

pp. 11-18 ◽

Cited By ~ 1

Author(s):

Kathleen Siobhan Barone ◽

Rachael Burns ◽

Stephanie Horton ◽

Armando Retana ◽

Lindsey Jackson Meredith Wall ◽

...

Keyword(s):

Oral Tolerance ◽

Low Dose ◽

Dose Oral

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Role of titrated low dose oral misoprostol solution in induction of labour

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20160583 ◽

2016 ◽

pp. 775-782 ◽

Cited By ~ 2

Author(s):

Sarvottma Antil ◽

Usha Gupta

Keyword(s):

Low Dose ◽

Induction Of Labour ◽

Oral Misoprostol ◽

Dose Oral

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Role of low dose oral minoxidil in the treatment of hair loss: A review

10.25259/csdm_29_2021 ◽

2021 ◽

Vol 1 ◽

pp. 38

Author(s):

Sajin Alexander ◽

Venkataram Mysore ◽

Ashwini L. Hirevenkangoudar

Keyword(s):

Treatment Option ◽

Hair Loss ◽

Low Dose ◽

Common Adverse Effect ◽

Side Effect Profile ◽

Online Search ◽

Good Compliance ◽

The World ◽

Dose Oral

Low-dose oral minoxidil (OM) has increasingly been used by many doctors around the world as a treatment option for hair loss. Sufficient data regarding its effect and side effect profile are lacking. An online search was done on PUBMED and GOOGLE SCHOLAR for articles that used OM as a treatment option for hair loss. Doses ranging from 0.25 to 5 mg have been used for treatment in various studies. Good compliance and tolerability have been noticed with low-dose OM therapy. Adverse effects are few and are mild with hypertrichosis being the most common adverse effect in a majority of the studies, the risk of which increases with an increase in dosage of the drug.

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