scholarly journals Role of levonorgestrel releasing intra-uterine system in the treatment of menorrhagia due to dysfunctional uterine bleeding and fibroid uterus

Author(s):  
Reena Gupta ◽  
Rupali Dewan ◽  
Pratima Mittal ◽  
Jyotsna Suri ◽  
Abhinav Dewan ◽  
...  
Author(s):  
Nikita Gandotra ◽  
Preeti Sharma ◽  
Abhinav Sharma ◽  
Syed Masuma Rizvi

Background: Dysfunctional uterine bleeding (DUB) is a common gynaecological disorder that usually ends up in hysterectomy and causes psychological and physiological stress. Medical management with hormones and NSAIDS has inherited side effects. Ormeloxifene, a selective estrogen receptor modulator, is emerging as a safe and effective agent for dysfunctional uterine bleeding. The objective of the study was to evaluate the role of ormeloxifene in medical management of dysfunctional uterine bleeding.Methods: 30 patients, on whom diagnosis of dysfunctional uterine bleeding was made, were included in the study. Patients were given ormeloxifene 60mg twice a week for 12 weeks and then once a week for 12 weeks. The primary outcome measures were menstrual blood loss (assessed by pictorial blood assessment chart score), hemoglobin concentration and endometrial thickness. The secondary outcome measures were acceptability and side effects of ormeloxifene.Results: There was a significant reduction in mean PBAC score from 316 to 52 after six months of treatment. The mean hemoglobin concentration increased significantly from 8.4 to 9.8 gms/dl with a rise of 1.4gm/dl (p <0.05). The mean pretreatment endometrial thickness was 10.8mm and it decreased significantly to 8.1mm after 6 months of treatment with ormeloxifene (p < 0.05). 76.7% of the women showed marked subjective improvement in symptoms. The most common side effect reported was amenorrhea (13.3%).Conclusions: Ormeloxifene can be considered as an effective and safe therapeutic option for the medical management of dysfunctional uterine bleeding.


Author(s):  
Aparna S ◽  
Maya Balakrishnan ◽  
Giby Thomas

Regular menstrual cycles with adequate quantity and duration of bleeding indicate good reproductive health, with variations in these being reflected as menorohagia, oligomenorrbea, dysmenorrbea, PCOD, infertility etc. Dysfunctional uterine bleeding is particularly common during adolescence and perimenopausal periods. It has been defined as a state of excessive uterine bleeding without clinically detectable organic, systemic and iatrogenic causes. DUB is caused by the abnormal functioning of hypothalamo – pituitary – ovarian axis. Nasya is a term applied generally when the medicine is administered through the nasal passage. It is considered as the most specific Panchakarama therapy used for the diseases of Siras (head) or Urdva jatru region, as nasal passage is regarded as the gateway to the head. In the present article the possible role of Nasya in the management of dysfunctional uterine bleeding is discussed. Nasya indirectly work on the entire body by improving the functioning of central nervous system and endocrine glands. The neurons which stimulate production of GnRH, originates from the olfactory area and GnRH is the regulator of gonadotropin hormones. The hormones of menstruation are under the control of these secreted by the pituitary. Nasya which is considered as having direct action on neuro-endocrinological system may regulate HPO axis and normalize the menstruation.


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