The predictive value of laboratory factors in evaluating the necessity of surgical treatment in crohn's disease

2020 ◽  
Vol 27 (1) ◽  
pp. 105
Author(s):  
Emine Gur ◽  
Elif Yuksel ◽  
Selda Haciyanli ◽  
Cem Cekic ◽  
Osman Dilek ◽  
...  
2021 ◽  
Author(s):  
Kristyna Zarubova ◽  
Ondrej Fabian ◽  
Ondrej Hradsky ◽  
Tereza Lerchova ◽  
Filip Mikus ◽  
...  

2015 ◽  
Vol 21 (22) ◽  
pp. 6952-6964 ◽  
Author(s):  
Nora Sipeki ◽  
Laszlo Davida ◽  
Eszter Palyu ◽  
Istvan Altorjay ◽  
Jolan Harsfalvi ◽  
...  

2014 ◽  
Vol 8 (9) ◽  
pp. 1022-1029 ◽  
Author(s):  
Graham D. Naismith ◽  
Lyn A. Smith ◽  
Sarah J.E. Barry ◽  
Joanna I. Munro ◽  
Susan Laird ◽  
...  

Abstract Background Faecal calprotectin (FC) is a non-invasive marker of gastrointestinal inflammation. Aim To determine whether higher FC levels in individuals with quiescent Crohn's disease are associated with clinical relapse over the ensuing 12 months. Methods A single centre prospective study was undertaken in Crohn's disease patients in clinical remission. The receiver operating characteristic (ROC) curve for the primary endpoint of clinical relapse by 12 months, based on FC at baseline, was calculated. Kaplan–Meier curves of time to relapse were based on the resulting optimal FC cutoff for predicting relapse. Results Of 97 patients recruited, 92 were either followed up for 12 months without relapsing, or reached the primary endpoint within that period. Of these, 10 (11%) relapsed by 12 months. Median FC was lower for non-relapsers, 96 μg/g (IQR 39–237), than for relapsers, 414 μg/g (IQR 259–590), (p = 0.005). The area under the ROC curve to predict relapse using FC was 77.4%. An optimal cutoff FC value of 240 μg/g to predict relapse had sensitivity of 80.0% and specificity of 74.4%. Negative predictive value was 96.8% and positive predictive value was 27.6%, FC ≥ 240 μg/g was associated with likelihood of relapse by 12-months 12.18 (95%CI 2.55–58.2) times higher than lower values (p = 0.002). Conclusions In this prospective dataset, FC is a useful tool to help identify quiescent Crohn's disease patients at a low risk of relapse over the ensuing 12 months. FC of 240 μg/g was the optimal cutoff in this cohort.


2016 ◽  
pp. 131-150
Author(s):  
Hiroki Ikeuchi ◽  
Motoi Uchino ◽  
Toshihiro Bando ◽  
Kei Hirose ◽  
Nobuyuki Hida ◽  
...  

2021 ◽  
Vol 100 (6) ◽  
pp. 78-85
Author(s):  
A.S. Bekin ◽  
◽  
E.Yu. Dyakonova ◽  
A.N. Surkov ◽  
A.P. Fisenko ◽  
...  

Crohn's disease (CD) is chronic recurrent bowel disease of unknown etiology, characterized by segmental transmural granulomatous inflammation, mainly with the development of local and systemic complications. Despite the active development of conservative therapy methods, the number of drug-resistant forms of CD and complications of the disease requiring surgical treatment continues to increase. The article reflects modern scientific ideas about the methods of diagnosis, conservative and surgical treatment of CD in children.


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