A histopathological and clinical assessment on the effect of microneedling on the autologous platelet-rich plasma in the experimental wound healing model Running Title: Assessment on effect of microneedling on PRP in the wound

2021 ◽  
Vol 28 (6) ◽  
pp. 1387
Author(s):  
Nese Ozkaya ◽  
Zeynep Inan ◽  
Umut Zereyak ◽  
Sarper Yilmaz
Keyword(s):  
Wound Healing ◽  
Clinical Assessment ◽  
Platelet Rich Plasma ◽  
Autologous Platelet Rich Plasma ◽  
Wound Healing Model ◽  
Healing Model ◽  
Autologous Platelet

Clinical Application of Platelet-Rich Plasma Gel (PRP) in Trauma Wounds of Extremities

2021 ◽  
Author(s):  
Jie Zhang ◽  
Xiaolin Feng ◽  
Yuxia Wang ◽  
Dakang Chen ◽  
Bo Zhang
Keyword(s):  
Wound Healing ◽  
Healing Rate ◽  
Platelet Rich Plasma ◽  
Healing Time ◽  
Second Stage ◽  
Autologous Platelet Rich Plasma ◽  
Wound Healing Time ◽  
Autologous Platelet ◽  
Tissue Defects ◽  
Wound Healing Rate

Research purposes: Autologous platelet-rich plasma gel (Platelet-Rich Plasma, PRP) was prepared and used for transplantation for the treatment of traumatic trauma wounds of extremities. Explore platelet-rich plasma gel (PRP) to promote the healing of exposed bone and tendon wounds. Methods: Fifteen patients with extremity bone and tendon exposed wounds were treated with autologous platelet-rich plasma gel (PRP) transplantation to observe the wound healing rate and wound healing time. Results: Among the 15 patients, 8 cases healed directly, 7 cases had active granulation growth, and second-stage skin graft wound healing; the wound healing rate was 100%, and the average wound healing time was 36 days. Conclusion: Autologous platelet-rich plasma gel (PRP) transplantation for the treatment of traumatic trauma hard wounds of the extremities, can inhibit the bacterial growth of the wounds, effectively promote the repair of soft tissue defects and accelerate the healing of bone and tendon wounds of the extremities.

scholarly journals Comparison of Allogeneic Platelet-rich Plasma With Autologous Platelet-rich Plasma for the Treatment of Diabetic Lower Extremity Ulcers

2020 ◽  
Vol 29 ◽  
pp. 096368972093142
Author(s):  
Min He ◽  
Xuewen Guo ◽  
Tao Li ◽  
Xiaoyan Jiang ◽  
Yan Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Lower Extremity ◽  
Adverse Reactions ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Ankle Brachial Index ◽  
Nutritional Regulation ◽  
Significant Difference ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Autologous platelet-rich plasma (au-PRP) has been widely used for the management of refractory chronic wounds. However, patients with diabetic lower extremity ulcers (DLEUs) usually have complicated clinical conditions, and the utility of au-PRP is limited. In this study, the feasibility, effectiveness, and safety of allogeneic platelet-rich plasma (al-PRP) and au-PRP were investigated and compared in the treatment of DLEUs. A total of 75 in-patients with type 2 diabetes were assigned to the al-PRP group ( n = 20), au-PRP group ( n = 25), and conventional wound therapeutic (CWT) group ( n = 30) matched by the ankle brachial index and ulcer size from December 2015 to August 2018. Based on metabolic and nutritional regulation, infective control, and topical wound management, al-PRP, au-PRP, and CWT were administered to each group, respectively. Evaluation of treatment outcomes was determined by the parameters of wound healing and adverse reactions. The therapeutic times and average concentration of platelets were not significantly different between the au-PRP and al-PRP groups. The wound healing times of the al-PRP group (56.9 ± 29.22 d) and au-PRP group (55.6 ± 33.8 d) were significantly shorter than those of the CWT group (88.0 ± 43.4 d) ( P < 0.01), but there was no significant difference between the groups with PRP treatment. Although there was no significant difference in the daily healing area among all groups ( P > 0.05), the trend of the healing rate in the al-PRP group (16.77 ± 12.85 mm2), au-PRP group (14.31 ± 18.28 mm2), and CWT group (9.90 ± 8.51 mm2) gradually decreased. No obvious adverse reactions (fever, edema, pain, skin itching, rash, or other sensory abnormalities) were observed in either the au-PRP or the al-PRP groups. Both al-PRP and au-PRP could effectively and safely promote wound healing in patients with DLEUs. Alternatively, al-PRP could be used for DLEUs as an off-the-shelf solution when au-PRP is limited. Registration number of clinical trials: ChiCTR1900021317

scholarly journals ON IMPROVING THE TREATMENT OF PATIENTS WITH CHRONIC WOUNDS OF VENOUS GENESIS

2019 ◽  
Vol 19 (3) ◽  
pp. 75-78
Author(s):  
Ya.V. Rybalka
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Control Group ◽  
Wound Area ◽  
Area Reduction ◽  
Autologous Platelet Rich Plasma ◽  
Group 2 ◽  
Autologous Platelet ◽  
Group 1

Introduction. The analysis of the effectiveness of applying autologous platelet-rich plasma was performed in order to improve the results of surgical treatment of patients with wounds that heal slowly. Materials. The study is based on the analysis of the treatment of 61 patients who suffered from slow-healing wounds of venous genesis with a diameter of no more than 8 cm on the lower extremities and took the treatment at the surgical ward. The proposed method was based on obtaining autologous enriched platelet plasma followed by its injection along the periphery of the wound. The degree of reduction of the wound surface area was assessed by the method of contact planimetry per day. The patients of the 1st group demonstrated the wound area reduction by 5.1 ± 0.6%, and the patients of the group 2 – by 1.8 ± 0.4% (p <0005). The results indicate an increase in the rate of wound healing in patients in group 1 compared with patients in group 2. During the entire follow-up period (12 weeks), complete wound epithelialisation occurred in 21 (70%) patients in group 1 and in 10 (33.3%) patients of the group 2. The wound area decreased by more than 50% in 6 patients of group 1 (20%) and in 2 (7%) patients of the control group. The wound area decreased less than by 50% in 3 patients in group 1 (10%), and in 19 patients in group 2 (60%). The use of PRP therapy has been proven to have a significant positive effect on the process of wound healing compared with the use of standard methods used for the control group. Conclusion: increase in the wound healing pace in patients of group 1 (test) compared with patients of group 2 (control) can be explained by using autologous platelet-enriched plasma as an additional means to the standard therapy.

scholarly journals Effect of Unloading Condition on the Healing Process and Effectiveness of Platelet Rich Plasma as a Countermeasure: Study on In Vivo and In Vitro Wound Healing Models

2020 ◽  
Vol 21 (2) ◽  
pp. 407 ◽  
Author(s):  
Francesca Cialdai ◽  
Alessandra Colciago ◽  
Desiré Pantalone ◽  
Angela Maria Rizzo ◽  
Stefania Zava ◽  
...  
Keyword(s):  
Wound Healing ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Physical Factors ◽  
Medical Evacuation ◽  
Fibroblast Migration ◽  
Wound Healing Model ◽  
Healing Model

Wound healing is a very complex process that allows organisms to survive injuries. It is strictly regulated by a number of biochemical and physical factors, mechanical forces included. Studying wound healing in space is interesting for two main reasons: (i) defining tools, procedures, and protocols to manage serious wounds and burns eventually occurring in future long-lasting space exploration missions, without the possibility of timely medical evacuation to Earth; (ii) understanding the role of gravity and mechanical factors in the healing process and scarring, thus contributing to unravelling the mechanisms underlying the switching between perfect regeneration and imperfect repair with scarring. In the study presented here, a new in vivo sutured wound healing model in the leech (Hirudo medicinalis) has been used to evaluate the effect of unloading conditions on the healing process and the effectiveness of platelet rich plasma (PRP) as a countermeasure. The results reveal that microgravity caused a healing delay and structural alterations in the repair tissue, which were prevented by PRP treatment. Moreover, investigating the effects of microgravity and PRP on an in vitro wound healing model, it was found that PRP is able to counteract the microgravity-induced impairment in fibroblast migration to the wound site. This could be one of the mechanisms underlying the effectiveness of PRP in preventing healing impairment in unloading conditions.

scholarly journals Effect of autologous platelet-rich plasma application on cutaneous wound healing in dogs

2016 ◽  
Vol 17 (1) ◽  
pp. 79 ◽  
Author(s):  
Cho-Hee Jee ◽  
Na-Young Eom ◽  
Hyo-Mi Jang ◽  
Hae-Won Jung ◽  
Eul-Soo Choi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Platelet Rich Plasma ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals Potential therapeutic effects of autologous platelet rich plasma on impaired wound healing: a prospective clinical study

2018 ◽  
Vol 4 (6) ◽  
pp. 820
Author(s):  
Sachin Upadhyay ◽  
Hashmukh Shantilal Varma ◽  
Sumit Yadav
Keyword(s):  
Wound Healing ◽  
Platelet Rich Plasma ◽  
Considerable Improvement ◽  
Response To Therapy ◽  
Therapeutic Effects ◽  
Time Duration ◽  
Days Of Therapy ◽  
Significant Difference ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

<p class="abstract"><strong>Background:</strong> The evolving state of technology in field of medicine has led to a plethora of new options in the realm of wound healing. The primary objective of present study was to assess the potential therapeutic effects of autologous platelet rich plasma in the healing of wound.</p><p class="abstract"><strong>Methods:</strong> A prospective clinical nonrandomized cohort study was performed in 50 patients (40 males, 10 females) with recalcitrant, chronic; non-healing wounds of different etiologies. Age ranged from 25 to 70 years (mean 39.14±13.38). Eligible patients were treated with autologous platelet rich plasma (PRP) at 4-days intervals for a maximum of 14 sessions. Patients were evaluated (reduction in size of the wound (area)) every week and continued until final healing has achieved. The primary outcome was positive response to therapy, defined as complete healing of the wound and absence of any raw area. Significance was set at p&lt;0.05.<strong></strong></p><p class="abstract"><strong>Results:</strong> The mean time duration to wound healing was 6.33 weeks (S.D±2.16). A statistically significant difference (p&lt;0.05) was observed between the baseline parameters and mean area after PRP injection. After 7 sessions (28 days of therapy) the wounds showed the significant change in wound surface area (p&lt;0.05). None of the patients developed deep or superficial wound infections.</p><p class="abstract"><strong>Conclusions:</strong> There is considerable improvement in wound characteristics like healthy granulation tissue, healing edge, pain, slough, bleeding on touch and discharge after 7 days of PRP therapy and considerable improvement on follow up.</p>

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