The effect of cystatin-C and pro-BNP in determining mortality in elderly patients with sepsis

2014 ◽  
Vol 20 (1) ◽  
pp. 47
Author(s):  
Oyku Arslan ◽  
Guzin Ozturk ◽  
Burak Arslan ◽  
Tufan Tukek
Keyword(s):  
Elderly Patients ◽  
Cystatin C

scholarly journals Kidney function estimates using cystatin C versus creatinine: Impact on medication prescribing in acutely hospitalized elderly patients

2018 ◽  
Vol 124 (4) ◽  
pp. 466-478 ◽  
Author(s):  
Esben Iversen ◽  
Ann Christine Bodilsen ◽  
Henrik Hedegaard Klausen ◽  
Charlotte Treldal ◽  
Ove Andersen ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Kidney Function ◽  
Cystatin C ◽  
Hospitalized Elderly ◽  
Hospitalized Elderly Patients ◽  
Medication Prescribing

Prognostic Value of Cystatin C Relative to Creatinine Clearance on Admission in Elderly Patients Hospitalized for Worsening CHF

2007 ◽  
Vol 13 (6) ◽  
pp. S52
Author(s):  
Shigeru Matsui ◽  
Junnichi Ishii ◽  
Masanori Okumura ◽  
Shino Kan ◽  
Tadashi Nakano ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Creatinine Clearance ◽  
Cystatin C ◽  
Prognostic Value

scholarly journals Population Pharmacokinetic Study of Ceftriaxone in Elderly Patients, Using Cystatin C-Based Estimates of Renal Function To Account for Frailty

2020 ◽  
Vol 64 (10) ◽  
Author(s):  
Shu Jin Tan ◽  
Matthew Cockcroft ◽  
Madhu Page-Sharp ◽  
Glenn Arendts ◽  
Timothy M. E. Davis ◽  
...  
Keyword(s):  
Renal Function ◽  
Elderly Patients ◽  
Cystatin C ◽  
Pharmacokinetic Study ◽  
Severe Renal Impairment ◽  
Population Pharmacokinetic ◽  
Pharmacokinetic Studies ◽  
Total Exposure ◽  
Population Pharmacokinetic Study ◽  
Trough Concentrations

ABSTRACT Ceftriaxone is widely used for respiratory and urinary infections in elderly and frail patients, but there are few pharmacokinetic studies. A prospective population pharmacokinetic study of ceftriaxone in adults over 65 years old was undertaken. Dried blood spots collected at baseline (predose) and 0.5, 1, 4, 8, and 24 h after administration of 1 g of ceftriaxone were assayed using a validated liquid chromatography-mass spectroscopy analytical method. Frailty was classified using the Edmonton frailty scale and grip strength via a hand dynamometer. Estimates of glomerular filtration rate were determined using creatinine-based and cystatin C-based equations. Of 26 patients recruited, 23 (88%) were vulnerable or very frail. Estimates of drug clearance improved significantly with a cystatin C-based estimate of renal function that accounted for frailty. Simulations indicate that the combined effects of ranges of size and renal function resulted in a 6-fold range in peak ceftriaxone concentrations and 9-fold range in total exposure (area under the concentration-time curve [AUC]). For elderly patients with moderate or severe renal impairment, 48-h dosing results in greater trough concentrations and total exposure than the trough concentrations and total exposure in patients with normal renal function receiving 24-h dosing. Cystatin C-based measures of renal function improved predictions of ceftriaxone clearance in elderly patients.

scholarly journals SP227PREDICTION OF MORTALITY IN ELDERLY PATIENTS WITH CHRONIC KIDNEY DISEASE - THE ROLE OF CYSTATIN C

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i162-i162
Author(s):  
Nina Hojs ◽  
Maša Knehtl ◽  
Robert Ekart ◽  
Radovan Hojs ◽  
Sebastjan Bevc
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Elderly Patients ◽  
Cystatin C

scholarly journals Dosing Optimization of Ampicillin-Sulbactam Based on Cystatin C in Elderly Patients with Pneumonia

2021 ◽  
Vol 44 (5) ◽  
pp. 732-736
Author(s):  
Kayoko Matsubara ◽  
Kazuaki Matsumoto ◽  
Yuta Yokoyama ◽  
Erika Watanabe ◽  
Yuki Enoki ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Cystatin C ◽  
Dosing Optimization

scholarly journals Cystatin C at Admission in the Intensive Care Unit Predicts Mortality among Elderly Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Maria Aparecida Dalboni ◽  
Daniel de Oliveira Beraldo ◽  
Beata Marie Redublo Quinto ◽  
Rosângela Blaya ◽  
Roberto Narciso ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Elderly Patients ◽  
Cystatin C ◽  
Independent Predictor ◽  
Kidney Injury ◽  
Roc Curves ◽  
Serum Levels ◽  
Serum Cystatin C ◽  
Serum Cystatin

Introduction. Cystatin C has been used in the critical care setting to evaluate renal function. Nevertheless, it has also been found to correlate with mortality, but it is not clear whether this association is due to acute kidney injury (AKI) or to other mechanism. Objective. To evaluate whether serum cystatin C at intensive care unit (ICU) entry predicts AKI and mortality in elderly patients. Materials and Methods. It was a prospective study of ICU elderly patients without AKI at admission. We evaluated 400 patients based on normality for serum cystatin C at ICU entry, of whom 234 (58%) were selected and 45 (19%) developed AKI. Results. We observed that higher serum levels of cystatin C did not predict AKI ( versus  mg/L; ). However, it was an independent predictor of mortality, H.R. = 6.16 (95% CI 1.46–26.00; ), in contrast with AKI, which was not associated with death. In the ROC curves, cystatin C also provided a moderate and significant area (0.67; ) compared to AKI (0.47; ) to detect death. Conclusion. We demonstrated that higher cystatin C levels are an independent predictor of mortality in ICU elderly patients and may be used as a marker of poor prognosis.

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