scholarly journals Application of Fast Atom Bombardment Collision-induced Dissociation Tandem Mass Spectrometry for Structural identification of Glycerolipids Isolated From Marine Sponge

2011 ◽  
Vol 2 (1) ◽  
pp. 8-11 ◽  
Author(s):  
Sun-Young Lee ◽  
Joo-Yeon Hong ◽  
Jee-H. Jung ◽  
Jong-Ki Hong
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Marine Sponge ◽  
Fast Atom Bombardment ◽  
Structural Identification ◽  
Collision Induced Dissociation ◽  
Tandem Mass

Isolation and structural identification of 9hydroxy-9desmethyl-cyclosporine

1990 ◽  
Vol 36 (11) ◽  
pp. 1875-1879 ◽  
Author(s):  
L D Bowers ◽  
D D Norman ◽  
X X Yan ◽  
D Scheeler ◽  
K L Carlson
Keyword(s):  
Mass Spectrometry ◽  
Fast Atom Bombardment ◽  
Structural Identification ◽  
Collision Induced Dissociation ◽  
Tandem Mass ◽  
Hplc Fraction ◽  
Nomenclature System ◽  
Fragment Ions ◽  
Tandem Mass Spectroscopy ◽  
The Difference

Abstract A metabolite of cyclosporine has been isolated and its structure identified through use of HPLC and tandem mass spectroscopy. Fast atom bombardment mass spectrometry of an HPLC fraction co-eluting with 1 eta hydroxy-cyclosporine (M17) indicated that the mass of this metabolite was 2 Da greater than that of cyclosporine. Further isolation by HPLC yielded a pure fraction, which we analyzed with tandem mass spectrometry. Linear acyl fragment ions originating from the metabolite under collision-induced dissociation were consistent with the difference in mass being associated with amino acid 9 in the cyclosporine backbone. We propose a nomenclature system for future discussion of cyclosporine metabolites.

Coaxial continuous flow fast atom bombardment in conjunction with tandem mass spectrometry for the analysis of biomolecules

1989 ◽  
Vol 61 (22) ◽  
pp. 2504-2511 ◽  
Author(s):  
Leesa J. Deterding ◽  
M. Arthur. Moseley ◽  
Kenneth B. Tomer ◽  
James W. Jorgenson
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Continuous Flow ◽  
Fast Atom Bombardment ◽  
Tandem Mass
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