scholarly journals Management of metastatic urothelial cancer: the role of surgery as an adjunct to chemotherapy

2013 ◽  
Vol 3 (6-S4) ◽  
pp. 228 ◽  
Author(s):  
Robert S. Svatek ◽  
Arlene Siefker-Radtke ◽  
Colin P. Dinney
Keyword(s):  
Metastatic Disease ◽  
Poor Prognosis ◽  
Multidisciplinary Approach ◽  
Urothelial Cancer ◽  
Short Term ◽  
Term Survival ◽  
Metastatic Urothelial Cancer ◽  
Localized Disease ◽  
Short Term Survival

Metastatic or unresectable disease is identified in approximately20% of patients presenting with invasive urothelial cancer. Inaddition, up to 50% of patients will develop metastases followingradical cystectomy for clinically localized disease. Multiagentcisplatin-based chemotherapy is considered standard first-linetreatment for these patients. Although urothelial cancer is considereda chemosensitive tumour, metastatic disease is associatedwith poor prognosis and short-term survival. Here, we review therole of a multidisciplinary approach to treating patients with metastaticurothelial cancer.

scholarly journals Role of Cholesterol and the Ganglioside GM1 in Entry and Short-Term Survival of Brucella suis in Murine Macrophages

2002 ◽  
Vol 70 (3) ◽  
pp. 1640-1644 ◽  
Author(s):  
Aroem Naroeni ◽  
Françoise Porte
Keyword(s):  
Lipid Rafts ◽  
Endocytic Pathway ◽  
Host Cells ◽  
Short Term ◽  
Term Survival ◽  
Murine Macrophages ◽  
Brucella Suis ◽  
Phagosomal Membrane ◽  
Short Term Survival

ABSTRACT Brucella species are gram-negative, facultative intracellular bacteria that infect humans and animals. These organisms can survive and replicate within a membrane-bound compartment inside professional and nonprofessional phagocytic cells. Inhibition of phagosome-lysosome fusion has been proposed as a mechanism for intracellular survival in both types of cells. We have previously shown that the maturation inhibition of the Brucella-containing phagosome appears to be restricted at the phagosomal membrane, but the precise molecular mechanisms and factors involved in this inhibition have yet to be identified. Interestingly, recent studies have revealed that caveolae or lipid rafts are implicated in the entry of some microorganisms into host cells and mediate an endocytic pathway avoiding fusion with lysosomes. In this study, we investigated the role of cholesterol and the ganglioside GM1, two components of lipid rafts, in entry and short-term survival of Brucella suis in murine macrophages, by using cholesterol-sequestering (filipin and β-methyl cyclodextrin) and GM1-binding (cholera toxin B) molecules. Our results suggest that lipid rafts may provide a portal for entry of Brucella into murine macrophages under nonopsonic conditions, thus allowing phagosome-lysosome fusion inhibition, and provide further evidence to support the idea that the phagosome maturation inhibition is restricted at the phagosomal membrane.

scholarly journals States Of Wisdom In Marketing During An Era Of Economic Turbulence

2011 ◽  
Vol 2 (9) ◽  
Author(s):  
Jack A. Lesser ◽  
Donald E. Saunders
Keyword(s):  
Great Depression ◽  
Cost Reduction ◽  
Short Term ◽  
Term Survival ◽  
Marketing Innovation ◽  
The Great Depression ◽  
Short Term Survival

In 1975, Cundiff (1975) wrote an editorial in the Journal of Marketing titled, What is the Role of Marketing in a Recession? The 1974/1975 recession was more damaging to the economy than any recession since the Great Depression. Implicit in his editorial was the momentary concern corporations would emphasize cost reduction over marketing innovation to insure their short-term survival. Numerous articles were published in response to his article about how marketing and consumers appeared to be changing during the period.

Genetic determinants of lung cancer short-term survival: the role of glutathione-related genes

Lung Cancer ◽  
2002 ◽  
Vol 35 (3) ◽  
pp. 221-229 ◽  
Author(s):  
Ping Yang ◽  
Akira Yokomizo ◽  
Henry D Tazelaar ◽  
Randolph S Marks ◽  
Timothy G Lesnick ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Genetic Determinants ◽  
Short Term ◽  
Term Survival ◽  
Short Term Survival

scholarly journals Clinical Insights Into the Biology and Treatment of Pancreatic Cancer

2016 ◽  
Vol 12 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Niharika B. Mettu ◽  
James L. Abbruzzese
Keyword(s):  
Pancreatic Cancer ◽  
Survival Rate ◽  
Metastatic Disease ◽  
Poor Prognosis ◽  
Management Strategies ◽  
Stage At Diagnosis ◽  
Localized Disease ◽  
The Relationship ◽  
Systemic Therapies

Pancreatic cancer is a devastating disease with a universally poor prognosis. In 2015, it is estimated that there will be 48,960 new cases of pancreatic cancer and that 40,560 people will die of the disease. The 5-year survival rate is 7.2% for all patients with pancreatic cancer; however, survival depends greatly on the stage at diagnosis. Unfortunately, 53% of patients already have metastatic disease at diagnosis, which corresponds to a 5-year survival rate of 2.4%. Even for the 9% of patients with localized disease confined to the pancreas, the 5-year survival is still modest at only 27.1%. These grim statistics highlight the need for ways to identify cohorts of individuals at highest risk, methods to screen those at highest risk to identify preinvasive pathologic precursors, and development of effective systemic therapies. Recent clinical and translational progress has emphasized the relationship with diabetes, the role of the stroma, and the interplay of each of these with inflammation in the pathobiology of pancreatic cancer. In this article, we will discuss these relationships and how they might translate into novel management strategies for the treatment of this disease.

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