Juxta-adrenal malignant schwannoma with lymph node metastases

Juxta-adrenal malignant schwannoma is a very rare tumour of neural crest cell origin. A 69-year-old woman visited for proper management of incidentally detected adrenal mass as part of a dyspepsia workup. Metabolic evaluation was unremarkable and imaging results suggested a malignant adrenal mass with lymphnode metastases. The patient underwent a left adrenalectomy with para-aortic lymphadenectomy. The diagnosis and its origin was confirmed by histologic and immunohistochemical studies. We report the first case of juxta-adrenal malignant schwannoma with lymph node metastases, and review the literature on this rare tumour.

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Mr Lymphography Using Iron Oxide Particles

Acta Radiologica ◽

10.1177/028418519303400103 ◽

1993 ◽

Vol 34 (1) ◽

pp. 10-15 ◽

Cited By ~ 24

Author(s):

M. Taupitz ◽

S. Wagner ◽

B. Hamm ◽

D. Dienemann ◽

R. Lawaczeck ◽

...

Keyword(s):

Lymph Node ◽

Iron Oxide ◽

Lymph Nodes ◽

Lymph Node Metastases ◽

Pulse Sequences ◽

Signal Loss ◽

Iron Oxide Particles ◽

Imaging Results ◽

Node Metastases ◽

Oxide Particles

MR images of the iliac lymph nodes of 25 VX2 carcinoma-bearing rabbits and of 5 tumor-free rabbits were obtained at 1.5 T before and after endolymphatic administration of superparamagnetic iron oxide particles (SPIO) at a dose of 1 μmol Fe per extremity. Imaging results were correlated with histology. In unenhanced images intranodal metastases were not detectable with any of the pulse sequences used and the signal intensities of tumor-free and metastatic lymph nodes did not differ significantly. After administration of the contrast medium, a significant signal loss (p≤0.05) occurred in the healthy lymph node tissue, whereas the signal intensity of lymph node metastases remained unchanged. In SPIO enhanced images, the threshold size for detection of lymph node metastases was 2 mm. Metastatic involvement was detected in 28 of the 30 tumorous lymph nodes with the SE 2 000/15 sequence but in a smaller number of lymph nodes with the sequences SE 500/22 (n = 27) and 2 000/65 (n = 21).

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Paraneoplastic Dermatomyositis Associated with Metastatic Seminoma

Case Reports in Urology ◽

10.1155/2016/7050981 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Hidekazu Yoshie ◽

Ryuto Nakazawa ◽

Wataru Usuba ◽

Hiroya Kudo ◽

Yuichi Sato ◽

...

Keyword(s):

Lymph Node ◽

Skin Biopsy ◽

Muscle Weakness ◽

Lymph Node Metastases ◽

Clinical Success ◽

Testicular Tumor ◽

First Case ◽

Node Metastases ◽

Pure Seminoma

We report the first case in Japan of paraneoplastic dermatomyositis with pure seminoma, a tumor that extremely rarely accompanies dermatomyositis. The patient presented to the hospital with muscle weakness and erythema and was diagnosed with dermatomyositis from skin biopsy. Routine radiological screening revealed testicular tumor and massive lymph node metastases. We initially performed orchiectomy along with conventional immunotherapy. However, muscle weakness gradually worsened, and he eventually showed dysphagia and forced respiration and became bedridden. Although he seemed close to being too unstable to tolerate further treatment, we started carefully adjusted chemotherapy comprising 4 courses of etoposide plus cisplatin, which proved highly successful. Lymph node metastases completely disappeared and swallowing and respiration fully normalized after completing chemotherapy. We believe that this clinical success was due to our decision to initiate chemotherapy even in such a weak patient.

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A case of contralateral inguinal lymph node metastases from breast cancer

Surgical Case Reports ◽

10.1186/s40792-021-01181-z ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Takeo Kimoto ◽

Norio Kohno ◽

Akiko Okamoto ◽

Kyosuke Ota ◽

Takafumi Tani ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Lymph Node Metastases ◽

Inguinal Lymph Node ◽

English Literature ◽

Joint Disease ◽

Internal Mammary Nodes ◽

First Case ◽

Abdominal Operations ◽

Node Metastases

Abstract Background Breast cancer is well known to tends to invade through the lymphatic chains mainly to the axillary and subclavian nodes or occasionally to the internal mammary nodes. However, inguinal lymph node metastasis from breast cancer is extremely rare. Case presentation We have experienced a case of an 82-year-old woman showing left inguinal lymph node metastases from right breast cancer. Previously, she had received five times abdominal operations and left artificial bone head replacement for metamorphous hip-joint disease. Although the metastases were firstly detected 46 months after the breast surgery, they had already existed at the time of the breast operation, which was retrospectively re-evaluated by CT examination. The progression pattern of inguinal lymph node metastases had much correlated with that of the breast cancer. She underwent inguinal lymph node dissections. Pathological findings revealed them being compatible with breast cancer origin. Conclusions This is the sixth case having been reported in English literature. Besides, this is the first case showing the contralateral spread to the primary breast cancer. One of the causes of this complex metastatic pattern is thought be ascribed to the previously performed prolific abdominal operations.

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Value of tumour marker S-100B in melanoma patients: a comparison to 18F-FDG PET and clinical data

Nuklearmedizin ◽

10.1055/s-0038-1623884 ◽

2002 ◽

Vol 41 (03) ◽

pp. 143-147 ◽

Cited By ~ 12

Author(s):

J. Kensy ◽

J. P. Frohmann ◽

P. Willkomm ◽

U. Reinhold ◽

F. Grünwald ◽

...

Keyword(s):

Lymph Node ◽

Metastatic Disease ◽

Lymph Node Metastases ◽

Fdg Pet ◽

Distant Metastases ◽

Whole Body ◽

Imaging Results ◽

Node Metastases ◽

Melanoma Patients ◽

18F Fdg

Summary Aim: The S-100B protein is commonly used in the immunohistochemical diagnosis of malignant melanoma and its metastases and has recently been introduced as a tumor marker in peripheral blood, whereas 18F-FDG PET is currently the most sensitive in-vivo imaging method for melanoma staging. Thus, the efficency of serum S-100B and 18F-FDG PET in the detection of metastatic disease in melanoma patients are compared. Methods: Serum S-100B was measured with a commercially available immunoradiometric assay. As part of primary tumour staging whole-body positron emission tomography (PET) with 18F labeled fluorodeoxy-D-glucose (18F-FDG) was performed in 67 patients suffering from cutaneous melanoma with a tumour thickness > 0.75 mm and a Clark-level III-V. Final diagnosis based on histology, morphologic imaging results and/or clinical follow-up after at least six months. Results: No evidence of disease was seen in 43 of 67 patients (64.2%), 11 patients (16.4%) presented with lymph node metastases, 13 patients (19.4%) had one or more distant metastases. Alltogether, 18 of 67 patients showed S-100B values > 0.2 µg/l, including two patients without metastatic disease, 3 of 11 patients with lymph node metastases, and the 13 patients with distant metastases. One patient showed false-positive FDG-uptake in the mediastinum, but presented with S-100B values off curve. Conclusion: Our data indicate that serum S-100B determination might be helpful in identifying melanoma patients with distant metastases. In comparison to 18F-FDG PET, the value of serum S-100B for lymph-node staging is limited.

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Ectopic adrenocortical carcinoma located in the ovary

Acta Endocrinologica ◽

10.1530/eje-16-0224 ◽

2016 ◽

Vol 175 (4) ◽

pp. K17-K23 ◽

Cited By ~ 7

Author(s):

Farida Chentli ◽

Nadia Terki ◽

Said Azzoug

Keyword(s):

Lymph Node ◽

Lymph Node Metastases ◽

Ovarian Tumor ◽

Histological Study ◽

Large Mass ◽

Lower Abdomen ◽

First Case ◽

Abdomen Ct ◽

Node Metastases ◽

The Right

Aim Ovarian corticosteroid-producing tumors are exquisitely rare. Our aim was to describe the first case observed in our practice. Case history A 34-year-old female was referred for Cushing’s syndrome (CS) occurring in the postpartum period. Clinical examination showed severe CS with diabetes mellitus, hypertension, and a large mass in the right lower abdomen. Biochemistry demonstrated corticotropin (ACTH)-independent CS (cortisol=1900ng/mL (n=50–250), ACTH<10pg/mL (n=20–46)) with estradiol and testosterone overproduction. Investigations Abdomen CT scan revealed a 14cm right ovarian mass and small adrenal glands. Surgical exploration found the ovarian tumor with hemoperitoneum and enlarged lymph nodes. Histological study confirmed adrenocortical tumor located in the ovary with a Weiss score >5, associated with peritoneal and lymph node metastases. Immunohistochemical staining was positive for inhibin-α, melan-A, and SF1, demonstrating tissue of adrenal origin. After surgery, plasma glucose level spontaneously returned to normal. However, the patient died on the second post-surgical day due to catastrophic pulmonary embolism. Conclusion In this reported case, clinical, hormonal, histological, and immunohistochemical findings confirmed a cortisol and sex hormone-producing ovarian tumor with peritoneal and lymph node metastases, a very rare but important condition to recognize.

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