scholarly journals Renal solitary fibrous tumour: A rare pathological entity

2014 ◽  
Vol 8 (9-10) ◽  
pp. 657
Author(s):  
Biao Dong ◽  
Jianjian Zhang ◽  
Gang Wang ◽  
Xiuyu Zhai ◽  
Yaowen Fu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Left Kidney ◽  
Mesenchymal Cell ◽  
Radical Resection ◽  
Solitary Fibrous Tumour ◽  
Retrograde Pyelography ◽  
Ki 67 ◽  
Spindle Cells ◽  
Cell Neoplasm ◽  
Immunohistochemical Studies

A solitary fibrous tumour (SFT) is a rare mesenchymal cell neoplasm that can develop at any site. SFT of the kidney is extremely rare. Recently, we had a case of solitary fibrous tumour involving the left kidney in a 71-year-old female patient. The SFT was incidentally found by imaging modalities at the time of a physical workup. Computed tomography and retrograde pyelography showed a 4 × 3.5 × 4-cm nodular mass in the middle poles of the left kidney adjacent to the renal pelvis. A laparoscopic radical resection of the left kidney was performed. The tumour was well-circumscribed and composed of a mixture of spindle cells; microscopically, we found dense collagenous bands. Immunohistochemical studies showed strong reactions with CD34, bcl-2 and CD99. A nuclear positivity with Ki-67 was observed in less than 1% of cells. The tumour was negative for desmin, SMA and CD117. Histopathological and immunohistochemical studies confirmed the diagnosis of a solitary fibrous tumour.

scholarly journals Solitary Fibrous Tumor of the Kidney: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Abdullah Demirtaş ◽  
Volkan Sabur ◽  
Hülya Akgün ◽  
Emre Can Akınsal ◽  
Deniz Demirci
Keyword(s):  
Solitary Fibrous Tumor ◽  
Cystic Lesion ◽  
Spindle Cell ◽  
Left Kidney ◽  
Ki 67 ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Fibrous Tumor ◽  
Immunohistochemical Studies ◽  
Hmb 45

Solitary fibrous tumor is a spindle cell neoplasm mostly originating from pleura; however, it has also recently been reported to be extrapleural. A 57-year-old man presented with left lumbal pain. Ultrasonography and computed tomography showed a cystic lesion of 14 × 11 cm with solid areas and septations in middle and lower poles of the left kidney. Radical nephrectomy was performed. Immunohistochemical studies showed strong reactions with CD34 and CD99. A nuclear positivity with Ki-67 was observed in less than 1% of cells. Despite repeated stainings with vimentin, no clear tumor evaluation could be made due to artifacts. The tumor was negative with Bcl-2, desmin, HMB-45, S100, FVIII, and CD31. Histopathological and molecular studies made the diagnosis of a solitary fibrous tumor. The patient is now currently free of disease at the 26th month of followup.

Fine-Needle Aspiration of Renal Angiosarcoma

2002 ◽  
Vol 126 (4) ◽  
pp. 478-480 ◽  
Author(s):  
Viviana V. Johnson ◽  
Erich M. Gaertner ◽  
Barbara A. Crothers
Keyword(s):  
Computed Tomography ◽  
Fine Needle Aspiration ◽  
Renal Mass ◽  
Left Kidney ◽  
Pulmonary Nodules ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Spindle Cells ◽  
Hepatic Nodule ◽  
Ancillary Studies

Abstract Angiosarcoma of the kidney is an unusual neoplasm, and primary renal angiosarcoma is exceedingly rare, with fewer than 11 well-documented cases reported to date. To our knowledge, no publication to date has correlated the fine-needle aspiration cytologic findings in renal angiosarcoma with the gross, histologic, and immunohistochemical findings. A 50-year-old man presented with a left kidney mass and multiple liver and pulmonary nodules. Computed tomography–guided fine-needle aspiration biopsies of the renal mass and a hepatic nodule were performed and demonstrated malignant spindle cells consistent with angiosarcoma. The diagnosis was confirmed at autopsy through histologic examination and associated ancillary studies. This case presents the fine-needle aspiration cytologic findings in renal angiosarcoma and correlates these findings with the gross pathologic, histologic, and immunohistochemical findings.

scholarly journals A nagy imitátor

2016 ◽  
Vol 157 (9) ◽  
pp. 350-356
Author(s):  
Mihály Murányi ◽  
Zoltán Kiss ◽  
Antal Farkas ◽  
Tibor Flaskó
Keyword(s):  
Computed Tomography ◽  
Antibiotic Treatment ◽  
Left Kidney ◽  
Retrograde Pyelography ◽  
Intravenous Antibiotics ◽  
Renal Tuberculosis ◽  
Purulent Fluid ◽  
Staghorn Stone ◽  
Ureteric Stricture ◽  
Left Flank Pain

Authors present two patients suffering from renal tuberculosis, which caused differential diagnostic problems. The first patient was examined because of fever and left flank pain. Computed tomography revealed renal shrinkage on the left side. Retrograde pyelography demonstrated ureteric stricture and dilated calices. Urine culture showed Mycobacterium tuberculosis. Two months after initiation of the antituberculotic therapy nephrectomy was performed. The second patient was referred to the department because of fever after unsuccessful antibiotic treatment. Ultrasound examination showed a staghorn stone, dilated renal pelvis and perirenal abscess on the left side. Double J catheter insertion and percutaneous puncture of the abscess were performed. Culture of the pus aspirated proved Proteus morganii. Fever and complaints of the patient relieved after antibiotic treatment. Two months later double J catheter was changed because of persistent pyelonephritis. One week later the patient returned to the hospital with fever, which could not be reduced with intravenous antibiotics. Computed tomography showed purulent fluid in the left kidney, and nephrectomy was performed. Histology revealed renal tuberculosis. The authors summarize the diagnosis and treatment of renal tuberculosis on the basis of these two cases. Orv. Hetil., 2016, 157(9), 350–356.

scholarly journals A Rare Solitary Fibrous Tumour of Kidney

2013 ◽  
Vol 52 (190) ◽  
Author(s):  
Tilak Bahadur Pathak ◽  
Umesh Nepal
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Pelvis ◽  
Spindle Cell ◽  
Pleural Cavity ◽  
Solitary Fibrous Tumour ◽  
Solid Mass ◽  
Spindle Cell Neoplasm ◽  
Published Report ◽  
Cell Neoplasm ◽  
Immunohistochemical Studies

A solitary fibrous tumour (SFT) is an unusual spindle cell neoplasm. It frequently arises from the serosal surface of pleural cavity but has recently been described in diverse extrapleural sites. Urogenital localization is rare and only 36 cases of SFTs of the kidney have been described on published report.  We report a case of a large SFT clinically and radiologically thought to be renal cell carcinoma arising in the kidney of a 30- year-old female. The radical nephrectomy was performed. The tumour was a well- circumscribed, solid mass attached to the renal pelvis without necrosis and haemorrhage. Histopathologically, a spindle cell neoplasia with alternating hypo and hypercellular areas, storiform, fascicular and hemangipericytoma- like growth pattern and less cellular dense collagen deposits were observed. Immunohistochemical studies revealed reactivity for CD34, CD99 and Bcl-2 protein. 

AGE FEATURES OF MOLECULAR-BIOLOGICAL SUBTYPES OF BREAST CANCER

2020 ◽  
Vol 17 (2) ◽  
pp. 187-192
Author(s):  
E.A. Novikova ◽  
◽  
O.V. Kostromina ◽  
D.V. Mikhailov ◽  
S.L. Leontiev ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptors ◽  
Age Groups ◽  
Luminal A ◽  
Ki 67 ◽  
Luminal B ◽  
Age Related ◽  
Age Features ◽  
Immunohistochemical Studies ◽  
Triple Negative Subtype

Aim. The aim of the study was to determine the presence of peculiarities of the age structure in patients with various surrogate molecular biological subtypes of breast cancer. Materials and research methods. This work analyzes the age-related characteristics of the occurrence of molecular biological subtypes in 499 patients with invasive breast cancer. All cases were divided into 5 molecular biological subtypes based on immunohistochemical studies of hormone receptors, Her2, Ki-67. The average age of the patients was 53.4±0.39 years, the predominant group was patients from 50 to 60 years (37.2% of the total). Research results. In patients under 40 years old, the triple negative subtype prevailed (44.8%). Luminal A subtype prevailed in the groups 51-60 years old (more than 41.4%) and over 60 years old (39.7%). Luminal B (Her2-) subtype was equally found in all age groups.

scholarly journals Angiosarcoma of sigmoid colon with intraperitoneal bleeding: case report and literature review

2011 ◽  
Vol 93 (6) ◽  
pp. e91-e93 ◽  
Author(s):  
Tse-Hua Lo ◽  
Mu-Shiun Tsai ◽  
Tzu-An Chen
Keyword(s):  
Sigmoid Colon ◽  
Alimentary Tract ◽  
Surgical Excision ◽  
Sigmoid Colectomy ◽  
Epithelioid Cells ◽  
Spindle Cells ◽  
Choice Of Treatment ◽  
Intraperitoneal Bleeding ◽  
Immunohistochemical Studies

Primary angiosarcomas arising from the alimentary tract are rare and only a few cases have been reported in the literature. We report a case of an angiosarcoma of the sigmoid colon with intraperitoneal bleeding but not rectal bleeding. A 21-year-old female patient received a laparotomy and a mass lesion over the sigmoid colon was found with active bleeding. A sigmoid colectomy was performed as a curative resection. Grossly, the sigmoid colon contained a kidney shaped, hemorrhagic tumour from the submucosal layer extension to the antimesenteric side. Intraluminally, the mucosa of the colon was intact. Microscopic examination revealed a high grade angiosarcoma composed of fascicles of spindle cells and solid sheets of epithelioid cells. Immunohistochemical stains revealed a positive result for CD31 and the endothelial nature of the malignancy was confirmed. Smooth muscle antigens, desmins, cytokeratins AE1/AE3 and CD117 were all negative. The patient is still alive without evidence of recurrence or metastasis at a three-year follow-up appointment. Owing to the availability of immunohistochemical studies, some atypical sarcomas would now be correctly classified as angiosarcomas. Since no optimal adjuvant treatment is effective, curative surgical excision is still the best choice of treatment.

scholarly journals Rapidly progressing blastic plasmacytoid dendritic cell neoplasm causing diffuse skin thickening: A case report with sequential computed tomography examinations

2021 ◽  
Vol 16 (10) ◽  
pp. 2929-2933
Author(s):  
Kyohei Yoshioka ◽  
Ryo Kurokawa ◽  
Shiori Amemiya ◽  
Hiroaki Koyamaa ◽  
Kensuke Matsuda ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cell ◽  
Cell Neoplasm

Malignant Transformation of Metaplastic Thymoma into High-Grade Sarcomatoid Carcinoma: A Case Report

2021 ◽  
pp. 106689692110704
Author(s):  
Zheng Hua Piao ◽  
Jin Ping Chen ◽  
Hai Ren Chen ◽  
Xin Cheng Zhou
Keyword(s):  
Mediastinal Mass ◽  
Spindle Cell ◽  
Postoperative Radiotherapy ◽  
Sarcomatoid Carcinoma ◽  
Anterior Mediastinal Mass ◽  
High Grade ◽  
Ki 67 ◽  
Cellular Atypia ◽  
Spindle Cells ◽  
Cell Components

The correlation of histogenesis between metaplastic thymoma and thymic sarcomatoid carcinoma is unclear. We report a case of metaplastic thymoma transformed into high-grade sarcomatoid carcinoma. A 64  ×  54  ×  32 mm anterior mediastinal mass in a 61-year-old woman microscopically consisted mainly of classic metaplastic thymoma, with the center dominated by high-grade sarcomatoid carcinoma. In some areas, both epithelial and spindle cell components of the metaplastic thymoma showed increased cellular atypia, mitotic activity, and focal necrosis and gradually transformed into the polygonal/pleomorphic and spindle cell components of sarcomatoid carcinoma. Immunohistochemically, the characteristics of the polygonal/pleomorphic sarcomatoid cells were similar to those of the epithelial component of metaplastic thymoma, while the spindle sarcomatoid cells were more similar to the spindle cells component of metaplastic thymoma. The Ki-67 index was less than 5% in the metaplastic thymoma areas but up to 70% in the sarcomatoid carcinoma area. Radical operation and postoperative radiotherapy were performed. Multifocal relapses at the pleura occurred 13 months after surgery.

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