scholarly journals Statin escape phenomenon: Fact or fiction?

2017 ◽  
Vol 7 (1) ◽  
pp. 25
Author(s):  
Fotios Barkas ◽  
Moses Elisaf ◽  
Eleftherios Klouras ◽  
Theodora Dimitriou ◽  
Nikolaos Tentolouris ◽  
...  
Keyword(s):  
1972 ◽  
Vol 223 (5) ◽  
pp. 1237-1245 ◽  
Author(s):  
J Mohring ◽  
B Mohring
Keyword(s):  

1987 ◽  
Vol 252 (1) ◽  
pp. R188-R192
Author(s):  
C. H. Metzler ◽  
D. G. Gardner ◽  
L. C. Keil ◽  
J. D. Baxter ◽  
D. J. Ramsay

The escape from the sodium-retaining effects of prolonged mineralocorticoid treatment in animals and humans was first noted over 40 yr ago, but despite intense study the mechanisms responsible for the escape phenomenon have not been identified. Putative “natriuretic hormones” have been proposed to account for the escape phenomenon. To determine whether atrial natriuretic peptides (ANP) could participate in the escape phenomenon, the mineralocorticoid deoxycorticosterone acetate (DOCA) was administered to conscious dogs for 14 days. Escape was accompanied by a doubling of plasma ANP concentration and four- to sevenfold increases in cardiac ANP messenger RNA. There were also significant increases in mean arterial blood pressure during the last 8 days of DOCA treatment. Thus increases in the synthesis and secretion of ANP and increases in atrial pressure may represent mechanisms that contribute to the escape from mineralocorticoid-induced sodium retention.


2014 ◽  
Vol 41 (12) ◽  
pp. 1058-1064 ◽  
Author(s):  
Akiko Yamauchi-Yamada ◽  
Takenobu Yamamoto ◽  
Yumi Nakayama ◽  
Kazuko Ikeda ◽  
Tomoko Miyake ◽  
...  

2005 ◽  
Vol 5 (1) ◽  
Author(s):  
Sasiwimol Juntrakul ◽  
Preecha Ruangvejvorachai ◽  
Shanop Shuangshoti ◽  
Supaporn Wacharapluesadee ◽  
Thiravat Hemachudha

2002 ◽  
Vol 135 (6) ◽  
pp. 1572-1578 ◽  
Author(s):  
Tohru Ugawa ◽  
Hirotoshi Kakuta ◽  
Hiroshi Moritani ◽  
Hisataka Shikama

1994 ◽  
Vol 22 (4) ◽  
pp. 301-306 ◽  
Author(s):  
Mitsuhide NARUSE ◽  
Takanobu YOSHIMOTO ◽  
Kiyoko NARUSE ◽  
Masami TANAKA ◽  
Mitsuyasu HASE ◽  
...  
Keyword(s):  

Author(s):  
Anamika Nath

Abstract: Here in this review paper we basically discuss about the two covid-19 originate hypothesis, one is zoonotic spill-over hypothesis and another is lab leak hypothesis. This lab leak hypothesis recently on news due to substantial evidence found by USA. There are other lab leak phenomenon happen in past like 1977 Russian flu, most critics believe in that time it was also a lab escape phenomenon. Our review paper is also focused on various covid variants, till now and there comparative study. Here in this paper, we attempt to find cause of the COVID origination, and also represent a comparative study of various SARS-COV2 variants. We also discussed how it seems in near future whether pandemic will end soon or we have to adopt to live with the virus? Keywords: Zoonotic Spillover hypothesis, Lab leak hypothesis, Alpha variant, Beta variant, Gamma variant, Delta variant, comparative study, pandemic, Covid-19, SARS-COV-2, Wuhan Institute of Virology, Wuhan Sea food market


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