scholarly journals The Evaluation of Cardiovascular Diseases in Patients Presenting to the Urology Outpatient Clinic with Erectile Dysfunction

2021 ◽  
Vol 10 (60) ◽  
pp. 38-43
Author(s):  
Fevzi Bedir ◽  
Hasan Kocatürk ◽  
Mehmet Sefa Altay ◽  
Hüseyin Kocaturk ◽  
Banu Bedir ◽  
...  
Biomolecules ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 709
Author(s):  
Dakshinamurthy Sivakumar ◽  
Sathish-Kumar Mudedla ◽  
Seonghun Jang ◽  
Hyunjun Kim ◽  
Hyunjin Park ◽  
...  

PDE9 inhibitors have been studied to validate their potential to treat diabetes, neurodegenerative disorders, cardiovascular diseases, and erectile dysfunction. In this report, we have selected highly potent previously reported selective PDE9 inhibitors BAY73-6691R, BAY73-6691S, 28r, 28s, 3r, 3s, PF-0447943, PF-4181366, and 4r to elucidate the differences in their interaction patterns in the presence of different metal systems such as Zn/Mg, Mg/Mg, and Zn/Zn. The initial complexes were generated by molecular docking followed by molecular dynamics simulation for 100 ns in triplicate for each system to understand the interactions’ stability. The results were carefully analyzed, focusing on the ligands’ non-bonded interactions with PDE9 in different metal systems.


2021 ◽  
Vol 14 (1) ◽  
pp. 68-76
Author(s):  
A.A. Kamalov ◽  
◽  
S.T. Matskeplishvili ◽  
M.E. Chaliy ◽  
D.A. Okhobotov ◽  
...  

Introduction. Erectile dysfunction (ED) combines many conditions leading to erectile dysfunction and disability to perform sexual intercourse. It was confirmed that the most common cause of ED is vascular disorders, primarily associated with atherosclerosis that leads to cardiovascular diseases. Objective. To analyze the available literature data about the methods for diagnosis vascular ED, including according to cardiovascular system status. Materials and methods. The results of the search in scientific databases Medline, EMBASE, Cochrane, Chinese BioMedical Literature Database, China National Knowledge Infrastructure, Elibrary.ru were analyzed. After a detailed verification of the reliability of sources, impact factors of journals and the sequence of presentation of the material, 63 most relevant scientific publications were selected directly for citation. Results. The first step of the vascular ED diagnosis is the monitoring of nocturnal penile tumescences. Next, the risk factors for cardiovascular diseases and ED are evaluated: anamnesis of elevated blood pressure, physical activity, smoking, body weight, measurement of blood pressure, blood analysis with the lipid and glycemic profiles. For the diagnosis of endothelial dysfunction (END), the determination of flow-dependent vasodilation of the brachial artery is used, with the possible determination of the rate of blood filling after decompression. After the END is confirmed in patients with ED, it is useful to determine the vascular age using the SCORE scale. For further management of the patient with ED and END, stratification of the associated with sexual activity cardiovascular complications risk is recommended. Conclusion. The proposed diagnostic algorithm will allow not only identify the vascular component of ED at an early stage, but also to avoid fatal cardiovascular complications by prescribing and recommending therapeutic and preventive measures to patients with asymptomatic cardiovascular diseases.


2020 ◽  
Vol 17 (8) ◽  
pp. 1489-1494 ◽  
Author(s):  
Edoardo Pozzi ◽  
Paolo Capogrosso ◽  
Luca Boeri ◽  
Federico Belladelli ◽  
Andrea Baudo ◽  
...  

2019 ◽  
Vol 16 (5) ◽  
pp. S29
Author(s):  
P. Capogrosso ◽  
E. Pozzi ◽  
E. Ventimiglia ◽  
W. Cazzaniga ◽  
L. Boeri ◽  
...  

Urology ◽  
1986 ◽  
Vol 27 (4) ◽  
pp. 322-327 ◽  
Author(s):  
R. Taylor Segraves ◽  
Harry W. Schoenberg ◽  
Larry Goldman ◽  
Jeffrey Ivanoff

2019 ◽  
Vol 13 (6) ◽  
pp. 155798831989388 ◽  
Author(s):  
Sevket Balta ◽  
Dimitri P. Mikhailidis

Endothelial dysfunction (ED) occurs early in the development of atherosclerosis. Predictors of vascular risk including obesity, hyperlipidemia, metabolic syndrome, diabetes mellitus, and hypertension are associated with both vascular endothelial and ED. Endocan is a novel marker of endothelial dysfunction, inflammation, and atherosclerosis. Raised endocan levels (usually measured by ELISA assays) were reported in some cardiovascular diseases and related conditions. Increased endocan levels may represent the endothelial and inflammatory components of the pathogenesis of ED and may, therefore, prove useful in clinical practice.


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