scholarly journals Simultaneous Quantification of Metolazoneand Ramiprilin Their Combined Dosage Form by First Order Derivative Spectroscopic Method

2015 ◽  
Vol 12 (2) ◽  
pp. 1-7
Author(s):  
Chhalotiya Usmangani K.
Keyword(s):  
Dosage Form ◽  
Spectroscopic Method ◽  
Order Derivative ◽  
First Order ◽  
Simultaneous Quantification

scholarly journals Development of New Analytical Method for Estimation of Lansoprazole in Bulk and Tablet dosage forms

2019 ◽  
Vol 12 (4) ◽  
pp. 63-69
Author(s):  
S R Karajgi ◽  
D T Mallikarjun ◽  
M Somashekhar ◽  
B Shivakumar
Keyword(s):  
Analytical Method ◽  
Dosage Form ◽  
Spectroscopic Method ◽  
Dosage Forms ◽  
Spectroscopic Technique ◽  
Order Derivative ◽  
First Order ◽  
Absorbance Maximum ◽  
Ich Guidelines ◽  
Tablet Dosage

The present paper reports a simple, accurate and precise spectroscopic technique for estimation of Lansoprazole by first order derivative technique in tablet dosage form. The spectroscopic method for estimation of Lansoprazole by first order derivative technique was carried out using methyl alcohol as solvent. The absorbance maximum was 275nm. Beers law observed in the range of 30 - 150μg/ml concentration. The recovery studies demonstrated the accuracy of the proposed procedure and the results were established as per ICH guidelines. The technique was used successfully for the estimation of Lansoprazole in bulk and tablet and pure dosage form.

scholarly journals Development and Validation of First-Order Derivative Spectrophotometry for Simultaneous Determination of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride in Pharmaceutical Dosage Form

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Kaminee Parmar ◽  
Sunil Baldania ◽  
Dimal Shah ◽  
Usmangani Chhalotiya ◽  
Naimin Parmar
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Correlation Coefficients ◽  
Order Derivative ◽  
Simultaneous Estimation ◽  
Pharmaceutical Dosage Form ◽  
Zero Crossing ◽  
Phenylephrine Hydrochloride ◽  
First Order ◽  
Crossing Point

A simple, precise, accurate, and economical spectrophotometric method has been developed for simultaneous estimation of levocetirizine dihydrochloride (LCT) and phenylephrine hydrochloride (PHE) by employing first-order derivative spectrophotometric method. The first-order derivative absorption at 240 nm (zero crossing point of PHE) was used for quantification of LCT and 283.2 nm (zero crossing point of LCT) for quantification of PHE. The linearity was established over the concentration range of 4–24 μg/mL and 8–48 μg/mL for LCT and PHE with correlation coefficients (r2) 0.9964 and 0.9972, respectively. The mean % recoveries were found to be in the range of 99.14%–100.43% for LCT and 98.73%–100.83% for PHE. The proposed method has been validated as per ICH guideline and successfully applied for the simultaneous estimation of LCT and PHE in combined tablet dosage form.

NOVEL ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF BROMOFENAC SODIUM IN BULK AND PHARMACEUTICAL DOSAGE FORM BY DERIVATIVE AND AUC SPECTROSCOPIC METHOD

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (01) ◽  
pp. 87-90
Author(s):  
S Raghu ◽  
S. Muneer. ◽  
K.B. Chandra sekhar ◽  
kiran B. Siva Sai ◽  
Keyword(s):  
Spectrophotometric Method ◽  
Method Development ◽  
Spectroscopic Method ◽  
Zero Order ◽  
Order Derivative ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms ◽  
First Order ◽  
Significant Difference

The present study was carried out to develop a simple and reliable derivative spectrophotometric method for the determination of bromofenac sodium in pharmaceutical dosage forms .The solutions of standard and the sample were prepared in distilled water The quantitative determination of the drug was carried out with zero order derivative (method A) values measured at 268 nm and first order (method B) derivative values measured at 258 nm , and two wavelengths 262nm and 274nm were selected for the determination AUC (method C) of integrated areas. Calibration graphs constructed at their wavelengths of determination, were linear within the concentration range of 2-12 μg/mL (r2 = 0.999) for zero order and (r2 = 0.997) first order derivative spectrophotometric method. No significant difference between the performance of the proposed methods regarding the mean values and standard deviations and is suitable for the routine quality control application of bromofenac sodium in its pharmaceutical formulations.

scholarly journals Analytical Method Development and Validation of First Order Derivative Spectrophotometric Method for Simultaneous Estimation of Telmisartan and Metformin Hydrochloride in their Combined Pharmaceutical Dosage Form

2020 ◽  
Vol 11 (01) ◽  
pp. 60-68
Author(s):  
Avani Khristi ◽  
John Baraka ◽  
Brijesh Dasvani
Keyword(s):  
Dosage Form ◽  
Method Development ◽  
Ultra Violet ◽  
Order Derivative ◽  
Metformin Hydrochloride ◽  
Simultaneous Estimation ◽  
Intermediate Precision ◽  
Pharmaceutical Dosage Form ◽  
First Order ◽  
Bulk Drug

Ultra Violet (UV) Sectrophotomertic method has been developed for simultaneous estimation of telmisartan and metformin hydrochloride in bulk drug in their combined dosage form by first-order derivative. This method developed by using Methanol: Water (50: 50 v/v). Linearity was found near to 1, for telmisartan and Metformin hydrochloride. For Intraday, Interday, Intermediate precision, Robustness, %RSD was found less than 2. % Recovery was found to be between ranges 98-106% for both the drugs. These results indicate that the method is accurate, precise, and simple. All validation Parameter results comply with ICH guidelines.

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